TEST BANK FOR LEHNE'S PHARMACOLOGY FOR NURSING
CARE, 12TH EDITION BY JACQUELINE BURCHUM & LAURA
ROSENTHA |ALL CHAPTERS | ANSWERS WITH
RATIONALES NEWEST VERSION
,CHAPTER 1: INTRODUCTION TO PHARMACOLOGY
1. Which of the following best describes pharmacology?
A. The study of disease processes in the human body
B. The study of drugs and their interactions with living systems
C. The study of patient care and nursing interventions
D. The study of surgical procedures
Answer: B
Rationale: Pharmacology is the study of drugs, their mechanisms of action,
therapeutic uses, and effects on living systems.
2. Which statement is true regarding generic and trade drug names?
A. Trade names are universal, while generic names vary by country
B. Generic names are assigned by the manufacturer, trade names by the
FDA
C. Generic names are the official drug names, while trade names are brand
names
D. Trade names are always cheaper than generic names
Answer: C
Rationale: Generic names are the official, universally recognized names of
drugs, while trade names are brand names created by manufacturers.
3. A nurse understands that the “first-pass effect” refers to:
A. The rapid absorption of a drug through the stomach lining
B. The metabolism of a drug in the liver before it reaches systemic
circulation
C. The excretion of a drug by the kidneys
D. The interaction between two drugs in the bloodstream
Answer: B
Rationale: The first-pass effect is when the liver metabolizes a drug before
it enters systemic circulation, reducing its bioavailability.
,4. Which route of drug administration bypasses the first-pass effect?
A. Oral
B. Rectal
C. Sublingual
D. Enteral
Answer: C
Rationale: Sublingual drugs are absorbed directly into the bloodstream via
the oral mucosa, bypassing the liver’s first-pass metabolism.
5. Pharmacokinetics is best described as:
A. The study of the effects of drugs on the body
B. The study of how drugs are absorbed, distributed, metabolized, and
excreted
C. The legal aspects of drug administration
D. The economic impact of medications
Answer: B
Rationale: Pharmacokinetics focuses on how the body handles drugs
through absorption, distribution, metabolism, and excretion.
6. A drug with a high protein-binding capacity:
A. Reaches its target tissues quickly
B. Has a prolonged duration of action
C. Is eliminated rapidly by the kidneys
D. Cannot cross cell membranes
Answer: B
Rationale: Drugs bound to plasma proteins are inactive until released,
prolonging their duration of action.
7. The therapeutic index (TI) of a drug indicates:
A. The speed of drug absorption
B. The ratio of toxic dose to therapeutic dose
C. The rate of drug metabolism in the liver
D. The degree of patient adherence
Answer: B
Rationale: TI = LD50/ED50, showing the margin of safety; a narrow TI
requires careful monitoring.
, 8. Which factor does NOT typically affect drug metabolism?
A. Age
B. Liver function
C. Gender
D. Route of administration
Answer: D
Rationale: Metabolism is mainly influenced by age, liver health, and
genetic factors, not the route by which a drug is administered.
9. A nurse is aware that drugs with a low molecular weight:
A. Are absorbed poorly
B. Cross membranes more easily
C. Bind strongly to plasma proteins
D. Cannot enter cells
Answer: B
Rationale: Low molecular weight drugs diffuse across cell membranes more
readily than larger molecules.
10.Which statement best describes pharmacodynamics?
A. How the body affects the drug
B. How the drug affects the body
C. The economic cost of drug therapy
D. Legal regulations for prescribing drugs
Answer: B
Rationale: Pharmacodynamics is the study of biochemical and
physiological effects of drugs and their mechanisms of action.
11.A patient is taking multiple medications. The nurse knows that drug-
drug interactions can:
A. Only increase therapeutic effects
B. Only decrease therapeutic effects
C. Alter drug absorption, metabolism, or excretion
D. Prevent adverse effects
Answer: C
Rationale: Drug interactions can enhance, reduce, or modify drug effects
through changes in absorption, distribution, metabolism, or excretion.
CARE, 12TH EDITION BY JACQUELINE BURCHUM & LAURA
ROSENTHA |ALL CHAPTERS | ANSWERS WITH
RATIONALES NEWEST VERSION
,CHAPTER 1: INTRODUCTION TO PHARMACOLOGY
1. Which of the following best describes pharmacology?
A. The study of disease processes in the human body
B. The study of drugs and their interactions with living systems
C. The study of patient care and nursing interventions
D. The study of surgical procedures
Answer: B
Rationale: Pharmacology is the study of drugs, their mechanisms of action,
therapeutic uses, and effects on living systems.
2. Which statement is true regarding generic and trade drug names?
A. Trade names are universal, while generic names vary by country
B. Generic names are assigned by the manufacturer, trade names by the
FDA
C. Generic names are the official drug names, while trade names are brand
names
D. Trade names are always cheaper than generic names
Answer: C
Rationale: Generic names are the official, universally recognized names of
drugs, while trade names are brand names created by manufacturers.
3. A nurse understands that the “first-pass effect” refers to:
A. The rapid absorption of a drug through the stomach lining
B. The metabolism of a drug in the liver before it reaches systemic
circulation
C. The excretion of a drug by the kidneys
D. The interaction between two drugs in the bloodstream
Answer: B
Rationale: The first-pass effect is when the liver metabolizes a drug before
it enters systemic circulation, reducing its bioavailability.
,4. Which route of drug administration bypasses the first-pass effect?
A. Oral
B. Rectal
C. Sublingual
D. Enteral
Answer: C
Rationale: Sublingual drugs are absorbed directly into the bloodstream via
the oral mucosa, bypassing the liver’s first-pass metabolism.
5. Pharmacokinetics is best described as:
A. The study of the effects of drugs on the body
B. The study of how drugs are absorbed, distributed, metabolized, and
excreted
C. The legal aspects of drug administration
D. The economic impact of medications
Answer: B
Rationale: Pharmacokinetics focuses on how the body handles drugs
through absorption, distribution, metabolism, and excretion.
6. A drug with a high protein-binding capacity:
A. Reaches its target tissues quickly
B. Has a prolonged duration of action
C. Is eliminated rapidly by the kidneys
D. Cannot cross cell membranes
Answer: B
Rationale: Drugs bound to plasma proteins are inactive until released,
prolonging their duration of action.
7. The therapeutic index (TI) of a drug indicates:
A. The speed of drug absorption
B. The ratio of toxic dose to therapeutic dose
C. The rate of drug metabolism in the liver
D. The degree of patient adherence
Answer: B
Rationale: TI = LD50/ED50, showing the margin of safety; a narrow TI
requires careful monitoring.
, 8. Which factor does NOT typically affect drug metabolism?
A. Age
B. Liver function
C. Gender
D. Route of administration
Answer: D
Rationale: Metabolism is mainly influenced by age, liver health, and
genetic factors, not the route by which a drug is administered.
9. A nurse is aware that drugs with a low molecular weight:
A. Are absorbed poorly
B. Cross membranes more easily
C. Bind strongly to plasma proteins
D. Cannot enter cells
Answer: B
Rationale: Low molecular weight drugs diffuse across cell membranes more
readily than larger molecules.
10.Which statement best describes pharmacodynamics?
A. How the body affects the drug
B. How the drug affects the body
C. The economic cost of drug therapy
D. Legal regulations for prescribing drugs
Answer: B
Rationale: Pharmacodynamics is the study of biochemical and
physiological effects of drugs and their mechanisms of action.
11.A patient is taking multiple medications. The nurse knows that drug-
drug interactions can:
A. Only increase therapeutic effects
B. Only decrease therapeutic effects
C. Alter drug absorption, metabolism, or excretion
D. Prevent adverse effects
Answer: C
Rationale: Drug interactions can enhance, reduce, or modify drug effects
through changes in absorption, distribution, metabolism, or excretion.
