PCEUT 531 CERTIFIED QUALITY EXAM WITH VERIFIED
QUESTIONS AND CORRECT ANSWERS
Variability in drug metabolism between individuals can lead to
differences in drug efficacy
TRUE
Equine thyroid script calls for 1/10 of a grain. This is eq to 600
mg
FALSE- 6.6 mg
Geometric addition
Used in lab to add carmine to lactose until all diluent has been
added to create a homogeneous mixture
Size 4 caps fil more than size 1
FALSE
,When compounding non sterile prescriptions, pharmacist must
adhere to USP 785 which requires all products have a beyond
use date
FALSE
Increase in temperature will always increase solubility
FALSE
Salting out effect is more effective for non electrolytes
TRUE
The higher the logp the more hydrophobic drug molecules are
TRUE
Van der Waals forces
Weakest intermolecular forces of attraction
,Ophthalmic solutions
Do not need to be exactly isotonic,
Must be sterile and free of solid particles,
Single dose don't contain anti-micorbial preservatives, EDTA is
NOT viscosity agent, they are usually buffered
Oral and Parenteral solutions
15% ethanol are self preserving, citric acid is an anti-oxitive,
coloring agents not allowed for both, water miscible solvents
are used as co solvents, Benzalkonium chloride is NOT an
antioxidant
W/O emulsions
Can be used to administer water-soluble drugs, usually
prepared with hydrophobic emulsifying agents, adding water
can inverse W/O to O/W, droplets will sediment in W/O, size of
droplet does not determine the type fo emulsion
Surfactants
, Many but not all emulsifying agents are surfactants, can
promote wetting of powder in suspensions, could provide
molecular bridging between particles in suspensions, anionic
and cationic surfactants are not compatible, nonionic less toxic
Suspensions
Not only used for oral and topical, liquid formulations of
water-insoluble drugs, if there is a distinct boundary between
the sediment and supernant shortly after preparation, then the
suspension prepares is flocculated, they are inherently
physically unstable as particles invariably sediment, distant
fluids do NOT have high viscosity on standing and low viscosity
on shaking
Pharmacokinetics
The disposition of the drug in the body over time
(ODT) Orally Disintegrating Tablet
Compressed tablets, intended for oral administration, NO
sugar coating
QUESTIONS AND CORRECT ANSWERS
Variability in drug metabolism between individuals can lead to
differences in drug efficacy
TRUE
Equine thyroid script calls for 1/10 of a grain. This is eq to 600
mg
FALSE- 6.6 mg
Geometric addition
Used in lab to add carmine to lactose until all diluent has been
added to create a homogeneous mixture
Size 4 caps fil more than size 1
FALSE
,When compounding non sterile prescriptions, pharmacist must
adhere to USP 785 which requires all products have a beyond
use date
FALSE
Increase in temperature will always increase solubility
FALSE
Salting out effect is more effective for non electrolytes
TRUE
The higher the logp the more hydrophobic drug molecules are
TRUE
Van der Waals forces
Weakest intermolecular forces of attraction
,Ophthalmic solutions
Do not need to be exactly isotonic,
Must be sterile and free of solid particles,
Single dose don't contain anti-micorbial preservatives, EDTA is
NOT viscosity agent, they are usually buffered
Oral and Parenteral solutions
15% ethanol are self preserving, citric acid is an anti-oxitive,
coloring agents not allowed for both, water miscible solvents
are used as co solvents, Benzalkonium chloride is NOT an
antioxidant
W/O emulsions
Can be used to administer water-soluble drugs, usually
prepared with hydrophobic emulsifying agents, adding water
can inverse W/O to O/W, droplets will sediment in W/O, size of
droplet does not determine the type fo emulsion
Surfactants
, Many but not all emulsifying agents are surfactants, can
promote wetting of powder in suspensions, could provide
molecular bridging between particles in suspensions, anionic
and cationic surfactants are not compatible, nonionic less toxic
Suspensions
Not only used for oral and topical, liquid formulations of
water-insoluble drugs, if there is a distinct boundary between
the sediment and supernant shortly after preparation, then the
suspension prepares is flocculated, they are inherently
physically unstable as particles invariably sediment, distant
fluids do NOT have high viscosity on standing and low viscosity
on shaking
Pharmacokinetics
The disposition of the drug in the body over time
(ODT) Orally Disintegrating Tablet
Compressed tablets, intended for oral administration, NO
sugar coating
