NSG 552 PSYCHO-PHARMACOLOGY WILKES EXAM #3 STUDY GUIDE SET QUESTIONS
WITH COMPLETE ANSWERS
First Line Treatments for alcohol use disorder (according to Study Guide & Dynamed) -
(answer)naltrexone and acamprosate
Second Line Treatments for alcohol use disorder (according to study guide but not dynamed) -
(answer)Disulfuram and Bupropion (not FDA approved for ETOH but second line according to study
guide)
Second Line Treatment for alcohol use disorder (according to Dynamed) - (answer)Disulfuram
Other off label medications for alcohol use disorder according to Dynamed - (answer)Topiramate,
gabapentin, baclofen
Other off label medications for alcohol use disorder according to Stahl's - (answer)Topiramate,
ondansetron
MOA of Naltrexone - (answer)Opioid Receptor Antagonist
MOA of Acamprosate - (answer)- weak GABAa agonist
- weak NMDA antagonist
(does not prevent withdrawal symptoms)
MOA of Disulfuram - (answer)inhibits enzyme (aldehyde dehydrogenase) in the liver
Bupropions role in alcohol use disorder - (answer)Can diminish cravings for etoh, treat underlying
anxiety/depression
Safety Risk associated with bupropion and etoh - (answer)bupropion increases the risk of seizures in
those going through etoh withdrawal
, NSG 552 PSYCHO-PHARMACOLOGY WILKES EXAM #3 STUDY GUIDE SET QUESTIONS
WITH COMPLETE ANSWERS
s/s ETOH intoxication - (answer)impaired fine motor control, impaired judgement and coordination,
ataxic gait, poor balance, lethargy, difficulty sitting upright, difficulty with memory and sitting upright,
N/V, coma in levels 300mg/dL and over with respiratory depression and death possible
S/S of etoh withdrawal - (answer)Mild: insomnia, irritability, hand tremor
Moderate: autonomic hyperactivity (diaphoresis, tachycardia, HTN), fever
Severe: seizures (12-48 hours post consumption), hallucinations, Delirium Tremens
Delirium Tremens - (answer)48-96 hours after last etoh consumption includes anxiety, anorexia,
nausea/vomiting, psychomotor agitation
Scale used to measure etoh withdrawal - (answer)CIWA
CIWA assesses: - (answer)n/v, tremor, paroxysmall sweats, anxiety, agitation, tactile disturbances,
auditory disturbances, visual disturbances, headaches, orientation
CIWA scoring - (answer)<10=mild
10-15=moderate
>15=severe
What medication is FDA approved for both opioid use disorder and alcohol use disorder? -
(answer)Naltrexone
What routes of administration exist for Naltrexone - (answer)PO, monthly injection (Vivitrol), implant
What is the First Line medication in maintaining abstinence after alcohol detoxification? -
(answer)Acamprosate
What medication can safely be used to treat alcohol use disorder in patients who keep drinking alcohol?
- (answer)Acamprosate
WITH COMPLETE ANSWERS
First Line Treatments for alcohol use disorder (according to Study Guide & Dynamed) -
(answer)naltrexone and acamprosate
Second Line Treatments for alcohol use disorder (according to study guide but not dynamed) -
(answer)Disulfuram and Bupropion (not FDA approved for ETOH but second line according to study
guide)
Second Line Treatment for alcohol use disorder (according to Dynamed) - (answer)Disulfuram
Other off label medications for alcohol use disorder according to Dynamed - (answer)Topiramate,
gabapentin, baclofen
Other off label medications for alcohol use disorder according to Stahl's - (answer)Topiramate,
ondansetron
MOA of Naltrexone - (answer)Opioid Receptor Antagonist
MOA of Acamprosate - (answer)- weak GABAa agonist
- weak NMDA antagonist
(does not prevent withdrawal symptoms)
MOA of Disulfuram - (answer)inhibits enzyme (aldehyde dehydrogenase) in the liver
Bupropions role in alcohol use disorder - (answer)Can diminish cravings for etoh, treat underlying
anxiety/depression
Safety Risk associated with bupropion and etoh - (answer)bupropion increases the risk of seizures in
those going through etoh withdrawal
, NSG 552 PSYCHO-PHARMACOLOGY WILKES EXAM #3 STUDY GUIDE SET QUESTIONS
WITH COMPLETE ANSWERS
s/s ETOH intoxication - (answer)impaired fine motor control, impaired judgement and coordination,
ataxic gait, poor balance, lethargy, difficulty sitting upright, difficulty with memory and sitting upright,
N/V, coma in levels 300mg/dL and over with respiratory depression and death possible
S/S of etoh withdrawal - (answer)Mild: insomnia, irritability, hand tremor
Moderate: autonomic hyperactivity (diaphoresis, tachycardia, HTN), fever
Severe: seizures (12-48 hours post consumption), hallucinations, Delirium Tremens
Delirium Tremens - (answer)48-96 hours after last etoh consumption includes anxiety, anorexia,
nausea/vomiting, psychomotor agitation
Scale used to measure etoh withdrawal - (answer)CIWA
CIWA assesses: - (answer)n/v, tremor, paroxysmall sweats, anxiety, agitation, tactile disturbances,
auditory disturbances, visual disturbances, headaches, orientation
CIWA scoring - (answer)<10=mild
10-15=moderate
>15=severe
What medication is FDA approved for both opioid use disorder and alcohol use disorder? -
(answer)Naltrexone
What routes of administration exist for Naltrexone - (answer)PO, monthly injection (Vivitrol), implant
What is the First Line medication in maintaining abstinence after alcohol detoxification? -
(answer)Acamprosate
What medication can safely be used to treat alcohol use disorder in patients who keep drinking alcohol?
- (answer)Acamprosate
