(Latest 2026 Update)
Advanced Pathophysiology
Actual Exam Questions and Verified
Answers – Chamberlain
, NR507 Final Exam
Time: 90 Minutes
Total Marks: 100
Instructions: Read all questions carefully. Choose the best answer
for multiple choice. Use clinical reasoning for short answers and
case studies.
*ANSWER KEY ON THE LAST PAGE
Section A: Multiple Choice Questions (30 Questions – 60
Marks)
Each question carries 2 marks. Choose the most appropriate
answer.
1. Which of the following best describes the pathophysiology of
Type 1 Diabetes Mellitus?
A. Insulin resistance
B. Autoimmune destruction of beta cells
C. Excess glucagon
D. Hypothalamic dysfunction
2. Which organ is primarily responsible for detoxifying
ammonia into urea?
A. Kidney
B. Liver
, C. Pancreas
D. Spleen
3. Which condition is characterized by the accumulation of
fluid in the alveoli, reducing gas exchange?
A. Asthma
B. ARDS
C. Bronchitis
D. COPD
4. What electrolyte imbalance is most commonly seen in
Addison’s disease?
A. Hypernatremia
B. Hypokalemia
C. Hyperkalemia
D. Hypercalcemia
5. A patient with COPD has a barrel-shaped chest. What is
the cause of this physical change? A. Airway
inflammation
B. Air trapping and hyperinflation
C. Decreased surfactant
D. Pulmonary fibrosis
6. The hallmark of Parkinson’s disease is:
, A. Demyelination
B. Amyloid plaque formation
C. Dopamine deficiency
D. Serotonin excess
7. Which of the following diseases is associated with
elevated TSH and low T3/T4?
A. Graves’ disease
B. Hyperthyroidism
C. Hashimoto's thyroiditis
D. Thyroid storm
8. Which process causes edema in nephrotic syndrome?
A. Decreased capillary permeability
B. Low serum albumin
C. Hypertension
D. Decreased GFR
9. What is the primary cause of pulmonary hypertension?
A. Right ventricular hypertrophy
B. Systemic vasodilation
C. Elevated pulmonary arterial pressure
D. Valvular insufficiency