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HESI Pharmacology Practice Test 2026 – 120+ Solved Questions on MAOIs, Insulin, Pain Management, Antidotes, and Drug Safety

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This expertly verified study set provides over 120 solved questions and answers for the HESI Pharmacology Practice Test 2026, aligned with the NinjaNerd 2025/2026 edition. Developed for practical exam readiness, the document focuses on core pharmacological knowledge essential for nursing and healthcare certification exams, covering both foundational concepts and critical clinical applications. Key focus areas include: Medication safety protocols, including the 5 rights of administration, proper techniques for insulin, IV, IM, SubQ, and transdermal delivery Antidotes and toxicity monitoring for medications such as lithium, digoxin, acetaminophen, and warfarin Clinical considerations for drug classes like opioids, antipsychotics, anticonvulsants, diuretics, antihypertensives, antibiotics, and antidepressants Essential drug interactions and adverse effects, e.g., MAOIs and tyramine, NSAIDs and renal function, and statin-induced myopathy Disease-specific treatments: Parkinson’s, MS, PUD, diabetes, glaucoma, asthma, and gout Client education tips and nursing priorities for prenatal drugs, chemotherapy side effects, insulin regimens during pregnancy, and more Interactive questions simulating real HESI formats with clear rationales and multiple correct answers where applicable Visuals such as tables and boxed answers throughout the document help reinforce content retention and test-taking confidence. Especially helpful for: Nursing students preparing for the HESI, ATI, or NCLEX LPN, RN, pharmacy technician, or pre-med learners Tutors, instructors, and clinical educators seeking classroom-tested content Students studying with Pharmacology Made Easy, Pharmacology Success, or NinjaNerd Pharmacology Review This resource is focused on clinical reasoning and pharmacotherapeutic safety, making it an essential companion for exam success and safe practice. Keywords: HESI pharmacology 2026, drug administration, medication safety, antidotes, insulin management, MAOI interactions, diuretics, opioids, pain management, drug toxicity, nursing pharmacology, IV therapy, NCLEX pharmacology, glaucoma meds, psych drugs

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HESI Pharmacology Practice
Test 2026 Exam Questions and
Answers | 100% Solved


The nurse reviews the new prescription, phenelzine (Nardil), a monoamine

oxidase inhibitor (MAOI), for a client with depression on the psychiatric unit.

Which information is most important for the nurse to assess?




A. Consumption of any alcohol or tyramine rich foods

B. Reports of nausea or vomiting

C. Therapeutic serum drug levels

,D. Blood pressure and pulse prior to taking each dose - 🧠 ANSWER ✔✔A


The nurse is administering haloperidol 0.5 mg IM PRN to a client for the

first time. What side effects should the nurse assess thr client during the

initial dose?




A. Bradykinesia

B. Dystonia

C. Somatization


D. Akathisia - 🧠 ANSWER ✔✔B


While reviewing the client's electronic medical record (EMR), the nurse

assesses a client who is at risk for a possible interaction with an over-the-

counter (OTC) decongestant. Which client health history should the nurse

report to the health care provider concerning the OTC medication? (Select

all that apply)




A. Type 1 diabetes mellitus (DM)

B. Closed angle glaucome

,C. Chronic hypertension

D. Rheumatoid arthritis


E. Crohn's disease - 🧠 ANSWER ✔✔B,C


A client prescribed ipratropium reports nausea, blurred vision, headaches,

and insomnia after using the inhaler. Which action should the nurse

implement first?




A. Withhold the medication and report symptoms and vital signs to the

healthcare provider

B. Give PRN medication for nausea and vomiting and evaluate client in 30

minutes

C. reassure client that the ipratropium given will alleviate the symptoms

D. Delay administration of ipratropium until the next maintenance

medication is scheduled - 🧠 ANSWER ✔✔A


A client diagnosed with multiple sclerosis is experiencing profound

weakness, blurry vision, and shooting pains in both legs. Which medication

is considered the best course of treatment for the nurse to administer?



COPYRIGHT©NINJANERD 2025/2026. YEAR PUBLISHED 2025. COMPANY REGISTRATION NUMBER: 619652435. TERMS OF USE. PRIVACY
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3

, A. High dose methylprednisolone intravenously

B. Baclofen three times a day

C. Broad spectrum antibiotic coverage orally


D. Immunomodulatory drug therapy periodically - 🧠 ANSWER ✔✔A


The nurse administers 30 mL of lactulose for a client with stage 2 hepatic

encephalopathy. Which assessment finding would indicate the medication

is being therapeutic?




A. A decrease in blood ammonia levels

B. A softening in the stools

C. An increase in glucose absorption


D. A suppression of gut acidification - 🧠 ANSWER ✔✔A


The nurse is teaching a client who is newly diagnosed with type 1 diabetes

about neutral protamine Hagedor (NPH) insulin. Which statement by the

client indicates an understanding of how the medication works?

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