Clearance of what drug is best characterzed by Ketamine
perfusion-dependent elimination
drug has a high hepatic extraction ratio >0.7 which is dependent on liver
ket blood flow
diazepam
thiopental
phenytoin
Drugs with an ester linkage are MOST susceptible to Hydrolysis
which type of metabolism?
Drugs with ester linkage have a long or short DOA short
The effect of probecenid and penicillin can be Potentiation
described as
potentiation
synergism
antagonism
addition
Pharmacokinetics _ Pharmacodynamics 2/5/2026
, Pharmacokinetics _ Pharmacodynamics Page 2
How to solve for ED50
TD50 = 500mg
Therapeutic index= 20
TD50/ED50
500mg/20= 25 mg ED50
intrinsic ability of a drug to elicit a given clinical effect efficacy
efficacy
affinity
potency
enatiomerism
Pharmacokinetics _ Pharmacodynamics 2/5/2026