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Nephrons
Ø Functional units of the kidney
Ø Cleanses the blood
Ø Balance the constituents of the circulation
Ø The afferent arterioles from a tuft of high-pressure capillaries about 200
um in diabeter the glomerus.
Ø The rest of the nephron consists of a continuous sophisticated tubule
who's proximal and surrounds the glomeruli this is Bowman's capsule.
Ø The glomerulus and bowman's capsule together form the renal
, corpuscle
Ø These glomerular capillaries filter the blood based on particle size.
Ø After passing through the renal corpuscle, the capillaries form a second
arteriole, the different arteriole.
Immunizations
Ø Primary prevention intervention
Ø Herd immunity
Ø Active immunity
- Immunization, onset within 2-4 weeks, protection lasts years to lifelong.
Ø Passive immunity
- Immunoglobulin, onset within hours, protection duration limited, often
only several months.
Endocrine regulation of kidney function
Ø Renin-angiotensin-aldosterone
Ø Antidiuretic hormone (ADH)
Ø Endothelin
Ø Natriuretic hormones (ANP, BNP)
Ø Parathyroid hormone
Tuberculosis
, Ø Mycobacterial infection
Ø Highly associated with developing world and poor hygiene
Ø Recent travel to developing world and their immigrants are at risk.
- Exam includes cavilary lesions and apical "fallout" on CXR as well as
positive T-spot or Mantoux skin test.
Ø Treatment
- Social quarantine of patient and family testing
- Mandatory reporting to dept of public heath
- Up to 4 drug combo therapy is typical "RIPE" (Rifampin, Isoniazid,
Pyrazinamide, ethambutol).
- Negative pressure.
Verruca/Condyloma
- Caused by HPV infection
- Contagious, but not cancerous
- Removal by cryotherapy, punch biopsy, excision, curettage, etc.
Thyroid storm
Ø Acute, life-threatening exacerbation of thyrotoxicosis, longstanding
untreated hyperthyroid.
Ø Precipitated by an acute event.
Ø Symptoms: high fever, CNS dysfunction.
Ø Treatment
- Treat underlying cause
- IV fluids, diuretics, cooling blankets, APAP, No ASA, BB, PTU or
methimazole, iodine.
, causes of kidney disease
- Diabetes and hypertension
- Polycystic kidney disease
- Infection
- Nephrotoxic agents
- Lupus nephritis
- igA glomerulonephritis
- Goodpasture syndrome
- lead poisoning
- renal artery stenosis
- Henoch-schoneit purpura
Primary prevention
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Ø immunizations, patient education, disease prevention, legistration.
Psoriasis vs. eczema
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