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Male Reproductive System
1. In a patient presenting with erectile dysfunction due to vascular
insufficiency, consider the cross-sectional anatomy of the penis. Referring
to the image below, which structure, labeled as the paired erectile tissues
flanking the urethra, is primarily responsible for the rigidity during erection
through engorgement with blood via the deep arteries, and what is the
most likely underlying mechanism if atherosclerosis affects the helicine
arteries branching from these?
med.libretexts.org
,23.2: Anatomy of the Male Reproductive System - Medicine LibreTexts
a. Corpus spongiosum; reduced nitric oxide release leading to inadequate
vasodilation
b. Corpus cavernosa; impaired venous occlusion causing venous leak
c. Tunica albuginea; fibrosis preventing expansion
d. Urethra; obstruction impeding blood flow
Correct Answer :- b. Corpus cavernosa; impaired venous occlusion causing
venous leak Explanation: The corpus cavernosa are the main erectile tissues,
filling with blood during arousal. Atherosclerosis in helicine arteries reduces
inflow, but the question emphasizes rigidity loss, often due to venous leak where
blood escapes prematurely. This involves nitric oxide-mediated smooth muscle
relaxation in trabeculae, and failure leads to dysfunction. Compare to corpus
spongiosum, which surrounds the urethra and prevents compression during
erection.
2. A 45-year-old male with infertility shows semen analysis with low motility
and abnormal morphology. Histologically, examining the seminiferous
tubules (as in the image below), which cell type, labeled as the supportive
cells with elongated nuclei interspersed among germ cells, is critical for
providing nutritional support, forming the blood-testis barrier, and
secreting inhibin to regulate FSH, and how might a mutation in the
androgen receptor affect this process?
,quizlet.com
Seminiferous Tubule Histology Diagram | Quizlet
a. Leydig cells; reduced testosterone leading to impaired spermatid maturation
b. Sertoli cells; disrupted barrier causing autoimmunity against sperm
c. Spermatogonia; halted mitosis preventing stem cell renewal
d. Myoid cells; weakened tubule contraction affecting sperm transport
Correct Answer :- b. Sertoli cells; disrupted barrier causing autoimmunity against
sperm Explanation: Sertoli cells (sustentacular cells) nurture developing sperm,
phagocytose excess cytoplasm, and maintain the blood-testis barrier via tight
junctions. Androgen receptor mutation (e.g., in androgen insensitivity syndrome)
impairs Sertoli function, leading to azoospermia or oligospermia, as testosterone
, is needed for barrier integrity and spermatogenesis. Contrast with Leydig cells,
which produce testosterone but are interstitial.
3. Tracing the pathway of sperm in the male reproductive system, as depicted
in the sagittal view below, which structure, labeled as the coiled tube on
the posterior testis, is responsible for sperm storage, maturation, and
acquisition of motility over 18-20 days, and what physiological change
occurs if a vasectomy is performed proximal to this structure?
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Male Reproductive System In Sagittal Section Labeled 3d Diagram Of Stock Photo
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a. Vas deferens; backpressure causing testicular atrophy
b. Epididymis; sperm reabsorption without affecting production
c. Seminal vesicle; reduced fructose in semen impacting energy