BYU NURS 300 EXAM 1 (WEEK 1-4) (Latest
Update ) Questions & Answers
{Grade A} 100% Correct
Pro-drugs definition - correct answer Drug that must 1st be conjugated to become
active
There are 4 main compartments the medication will be distributed to? - correct
answer -Blood
-Fat
-Extracellular Fluid
-Intracellular fluid
•There are also several minor compartments? - correct answer -CSF
-Peritoneum
Synovial fluid
,Hydrophilic drugs? - correct answer cant reach sites as easily/well as lipophilic
Benedryl is an example of? - correct answer lipophilic med (works really well and
fast)
Claritin - correct answer derivative of benadryl, but it is hydrophilic, so it doesnt work
as fast (doesnt cros BBB) so it can be taken during the day and the pt wont be sleepy
Premature babies are at higher risk for? - correct answer drug toxicity, because their
BBB is not developed well yet
The bigger transporter for blood and medications? - correct answer albumin - all older
people have lower albumin, so they can have toxicity more easily.
,Plasma protein binding and drug availability - correct answer (a) drug exists in a free
state or bound to plasma protein; (b) drug-protein complexes are too large to cross
membranes
•Equalization of distribution of a medication to all compartments is dependent on what
factors? - correct answer •Permeability (Blood Brain Barrier)
•ph
•Binding capacity
•Fat solubility of the drug
Cyp450 - correct answer Enzyme family most important in metabolizing drugs
Always available in the liver
Evolved to eliminate toxic chemicals from plants
Function can be altered by alcohol & barbiturates
, •Metabolism happens in the? - correct answer •liver, lungs, and gut as well as other
areas
CYP450 system happens? - correct answer primary in the liver
•50% of meds are metabolized by the? - correct answer •CYP3A4 enzyme.
Most drug metabolism takes place in the? - correct answer liver
Diseases That Affect Drug Metabolism? - correct answer •Liver disease
•Cardiovascular disease
•Thyroid disease
•Malfunctions of the pituitary and adrenal cortex
Inflammatory diseases (infection, cancer, other inflammatory diseases
Update ) Questions & Answers
{Grade A} 100% Correct
Pro-drugs definition - correct answer Drug that must 1st be conjugated to become
active
There are 4 main compartments the medication will be distributed to? - correct
answer -Blood
-Fat
-Extracellular Fluid
-Intracellular fluid
•There are also several minor compartments? - correct answer -CSF
-Peritoneum
Synovial fluid
,Hydrophilic drugs? - correct answer cant reach sites as easily/well as lipophilic
Benedryl is an example of? - correct answer lipophilic med (works really well and
fast)
Claritin - correct answer derivative of benadryl, but it is hydrophilic, so it doesnt work
as fast (doesnt cros BBB) so it can be taken during the day and the pt wont be sleepy
Premature babies are at higher risk for? - correct answer drug toxicity, because their
BBB is not developed well yet
The bigger transporter for blood and medications? - correct answer albumin - all older
people have lower albumin, so they can have toxicity more easily.
,Plasma protein binding and drug availability - correct answer (a) drug exists in a free
state or bound to plasma protein; (b) drug-protein complexes are too large to cross
membranes
•Equalization of distribution of a medication to all compartments is dependent on what
factors? - correct answer •Permeability (Blood Brain Barrier)
•ph
•Binding capacity
•Fat solubility of the drug
Cyp450 - correct answer Enzyme family most important in metabolizing drugs
Always available in the liver
Evolved to eliminate toxic chemicals from plants
Function can be altered by alcohol & barbiturates
, •Metabolism happens in the? - correct answer •liver, lungs, and gut as well as other
areas
CYP450 system happens? - correct answer primary in the liver
•50% of meds are metabolized by the? - correct answer •CYP3A4 enzyme.
Most drug metabolism takes place in the? - correct answer liver
Diseases That Affect Drug Metabolism? - correct answer •Liver disease
•Cardiovascular disease
•Thyroid disease
•Malfunctions of the pituitary and adrenal cortex
Inflammatory diseases (infection, cancer, other inflammatory diseases
