PATHOPHYSIOLOGY 8TH EDITION MCCANCE
CERTIFICATION EVALUATION 2026 QUESTIONS
WITH SOLUTIONS GRADED A+
◉ The function of a histone found in a eukaryote cell focuses on
cellular
A. division.
B. movement.
C. activities.
D. deoxyribonucleic acid (DNA) folding. Answer: D. deoxyribonucleic
acid (DNA) folding.
The histones are binding proteins that cause the supercoiling of DNA
into chromosomes and do not affect cellular division, movement, or
activities.
Ch01.2
◉ An organelle that is responsible for the metabolism of cellular
energy is referred to as a/an
A. Golgi complex.
,B. mitochondrion.
C. endoplasmic reticulum.
D. nucleolus. Answer: B. mitochondrion
Mitochondria play a role in cellular metabolism, cellular respiration,
and energy production. The Golgi complex is responsible for
processing and packaging proteins from the endoplasmic reticulum,
where they are synthesized. The nucleolus is a small, dense
structure that contains the ribonucleic acid (RNA), DNA, and DNA-
binding proteins.
Ch01.3
◉ Which statement best describes a desmosome?
A. A desmosome is a barrier to diffusion.
B. Desmosomes hold cells together by continuous bands.
C. A desmosome is a communicating tunnel.
D. Desmosomes function as a zona occludens. Answer: B.
Desmosomes hold cells together by continuous bands.
The desmosome is a type of cell junction. The other two types
include tight junctions and gap junctions. Desmosomes hold cells
together by forming a continuous band of epithelial tissue or belt (or
button-like) points of contact. They are also a source of structural
,stability. Tight junctions serve as barriers to diffusion and prevent
the movement of substances through transport proteins. Gap
junctions are clusters of communicating tunnels.
Ch01.4
◉ Which statement describes the function of a second messenger?
A. Binds with membrane-bound receptors via a ligand
B. Triggers a cascade of intracellular events
C. Opens specific channels in the cell membrane
D. Blocks a membrane-bound receptor signal Answer: B. Triggers a
cascade of intracellular events
The binding of a ligand to a cell surface receptor triggers the
activation of intracellular second messengers. Second messengers
activate signal transduction pathways in the cell that can initiate
different intracellular events. Cyclic adenosine monophosphate
(cAMP) and calcium (Ca++) are the two major second-messenger
pathways. First messengers are the extracellular ligands that bind to
cell surface receptors. Binding of first messengers can result in the
opening or closing of specific cell membrane channels or the
activation of second messengers.
Ch01.5
◉ Which statement is correct regarding cellular energy?
, A. Glycolysis is the building of sugar molecules.
B. Oxidative cellular metabolism is a single reaction making
adenosine triphosphate
(ATP).
C. Oxidative phosphorylation occurs in the mitochondria.
D. Anaerobic glycolysis occurs in the presence of oxygen. Answer: C.
Oxidative phosphorylation occurs in the mitochondria.
Oxidative phosphorylation occurs in the mitochondria. This is the
mechanism by which the energy produced from carbohydrates, fats,
and proteins is transferred to ATP. Glycolysis is a process that breaks
down glucose molecules; it produces a net of two ATP molecules.
Oxidation is a process during which a pair of electrons are removed
and transferred. Oxidative cellular metabolism involves 10
biochemical reactions. Anaerobic glycolysis occurs in the absence of
oxygen. Aerobic means in the presence of oxygen.
Ch01.6
◉ Movement of a solute molecule from an area of high concentration
to an area of low concentration is called
A. diffusion.
B. filtration.
CERTIFICATION EVALUATION 2026 QUESTIONS
WITH SOLUTIONS GRADED A+
◉ The function of a histone found in a eukaryote cell focuses on
cellular
A. division.
B. movement.
C. activities.
D. deoxyribonucleic acid (DNA) folding. Answer: D. deoxyribonucleic
acid (DNA) folding.
The histones are binding proteins that cause the supercoiling of DNA
into chromosomes and do not affect cellular division, movement, or
activities.
Ch01.2
◉ An organelle that is responsible for the metabolism of cellular
energy is referred to as a/an
A. Golgi complex.
,B. mitochondrion.
C. endoplasmic reticulum.
D. nucleolus. Answer: B. mitochondrion
Mitochondria play a role in cellular metabolism, cellular respiration,
and energy production. The Golgi complex is responsible for
processing and packaging proteins from the endoplasmic reticulum,
where they are synthesized. The nucleolus is a small, dense
structure that contains the ribonucleic acid (RNA), DNA, and DNA-
binding proteins.
Ch01.3
◉ Which statement best describes a desmosome?
A. A desmosome is a barrier to diffusion.
B. Desmosomes hold cells together by continuous bands.
C. A desmosome is a communicating tunnel.
D. Desmosomes function as a zona occludens. Answer: B.
Desmosomes hold cells together by continuous bands.
The desmosome is a type of cell junction. The other two types
include tight junctions and gap junctions. Desmosomes hold cells
together by forming a continuous band of epithelial tissue or belt (or
button-like) points of contact. They are also a source of structural
,stability. Tight junctions serve as barriers to diffusion and prevent
the movement of substances through transport proteins. Gap
junctions are clusters of communicating tunnels.
Ch01.4
◉ Which statement describes the function of a second messenger?
A. Binds with membrane-bound receptors via a ligand
B. Triggers a cascade of intracellular events
C. Opens specific channels in the cell membrane
D. Blocks a membrane-bound receptor signal Answer: B. Triggers a
cascade of intracellular events
The binding of a ligand to a cell surface receptor triggers the
activation of intracellular second messengers. Second messengers
activate signal transduction pathways in the cell that can initiate
different intracellular events. Cyclic adenosine monophosphate
(cAMP) and calcium (Ca++) are the two major second-messenger
pathways. First messengers are the extracellular ligands that bind to
cell surface receptors. Binding of first messengers can result in the
opening or closing of specific cell membrane channels or the
activation of second messengers.
Ch01.5
◉ Which statement is correct regarding cellular energy?
, A. Glycolysis is the building of sugar molecules.
B. Oxidative cellular metabolism is a single reaction making
adenosine triphosphate
(ATP).
C. Oxidative phosphorylation occurs in the mitochondria.
D. Anaerobic glycolysis occurs in the presence of oxygen. Answer: C.
Oxidative phosphorylation occurs in the mitochondria.
Oxidative phosphorylation occurs in the mitochondria. This is the
mechanism by which the energy produced from carbohydrates, fats,
and proteins is transferred to ATP. Glycolysis is a process that breaks
down glucose molecules; it produces a net of two ATP molecules.
Oxidation is a process during which a pair of electrons are removed
and transferred. Oxidative cellular metabolism involves 10
biochemical reactions. Anaerobic glycolysis occurs in the absence of
oxygen. Aerobic means in the presence of oxygen.
Ch01.6
◉ Movement of a solute molecule from an area of high concentration
to an area of low concentration is called
A. diffusion.
B. filtration.
