IC3 - Antibiotica PK/PD en Antibioticabeleid
(Antimicrobial Stewardship)
Voorbereiding
a. Alle informatie uit de bachelor kunnen jullie vinden in de e-module “Pharmacology of
antibiotics in veterinary medicine”
b. lees de eerste twee alinea's van “Overview of Antimicrobials for Animals” (Merck
Veterinary Manual).
Treatment with chemotherapeutic agents involves complex interrelationships among the
host animal, infecting pathogen, and drug, the interactions of which comprise the
chemotherapeutic triangle. Whenever a drug is used with the intent to kill the target,
multiple factors affect therapeutic success. For instance, the target organism will implement
mechanisms to avoid harm—most notably, resistance mechanisms. Microbes in particular
are associated with numerous virulence factors and other mechanisms for self-protection,
often also making the host sick at the same time. Likewise, host factors, which seemingly
should help the host fend off infection, can become detrimental to successful treatment.
For most infections, successful treatment depends on the host having a functional immune
system. Drug factors also influence the success of treatment, most notably because drugs
must be able to penetrate the site of infection to successfully kill the microbe. These are the
interactions between the three points of the chemotherapeutic triangle: host, pathogen,
and drug. If the goal of antimicrobial treatment is simply to resolve clinical signs of infection,
then attention may not be given to the critically important aspects of treatment, such as
toxicity or mitigating future resistance.
,^Diagram of the chemotherapeutic triangle, a representation of the complex
interrelationship between drug factors, host factors, and pathogen factors in the treatment
of an infectious disease. The pharmacokinetics of a drug are encapsulated in the elimination
and toxicity arm of the triangle, and the pharmacodynamics of a drug are encapsulated in
the impairment-destruction and resistance-response arm.
De video's onder "Design of Dosing Regimens for Animals" zijn uitstekende opfrissers van
fundamentele farmacologische kennis. Deze video's zijn beter te bekijken op YouTube met
ondertiteling:
https://www.youtube.com/watch?v=Tsp9t3D2TL0
https://www.youtube.com/watch?v=KkS8H9EeS5I
c. Bekijk onderstaande 7 kennisclips ter voorbereiding van het interactieve hoorcollege
Antibiotica PK/PD en Antibioticabeleid (Antimicrobial Stewardship). Tijdens het college is het
vooral de bedoeling met vragen stellen en discussie over deze begrippen heel helder te
krijgen! Klik op de links om de clips te bekijken. In de powerpointpresentaties kun je de
afzonderlijke slides ook in BrightSpace bekijken (dus geen ss gemaakt maar verwijzing naar
dia’s)
- Vul voor jezelf dit Excel bestand in -> zie Excel bestand ‘tabel antibiotica IC3 MI Ma1
P1’
, 1. PK/PD kennisclip De antibiotica-evenwichtsoefening (7 min)
-
Tijdsafh zoals penicilline -> conc zo lang mogelijk op MIC houden
- Conc afh -> korte krachtige piek hoog boven MIC -> leidt vaak tot minder
bijwerkingen
- AB moet door ADME route
- Penicilline moet bv met pilletje want kan oraal niet door geen abs
- Lipofiele gaan bloed uit, hydrofiel blijft meer in bloed
- MIC = minimale remmende conc = hoe gevoelig bact is voor AB
-
- 2. kennisclip AMS-selectie van resistentie (16 min)
- Bacterien repliceren heel snel waardoor resistentie snel ontstaat
- !! ->
(Antimicrobial Stewardship)
Voorbereiding
a. Alle informatie uit de bachelor kunnen jullie vinden in de e-module “Pharmacology of
antibiotics in veterinary medicine”
b. lees de eerste twee alinea's van “Overview of Antimicrobials for Animals” (Merck
Veterinary Manual).
Treatment with chemotherapeutic agents involves complex interrelationships among the
host animal, infecting pathogen, and drug, the interactions of which comprise the
chemotherapeutic triangle. Whenever a drug is used with the intent to kill the target,
multiple factors affect therapeutic success. For instance, the target organism will implement
mechanisms to avoid harm—most notably, resistance mechanisms. Microbes in particular
are associated with numerous virulence factors and other mechanisms for self-protection,
often also making the host sick at the same time. Likewise, host factors, which seemingly
should help the host fend off infection, can become detrimental to successful treatment.
For most infections, successful treatment depends on the host having a functional immune
system. Drug factors also influence the success of treatment, most notably because drugs
must be able to penetrate the site of infection to successfully kill the microbe. These are the
interactions between the three points of the chemotherapeutic triangle: host, pathogen,
and drug. If the goal of antimicrobial treatment is simply to resolve clinical signs of infection,
then attention may not be given to the critically important aspects of treatment, such as
toxicity or mitigating future resistance.
,^Diagram of the chemotherapeutic triangle, a representation of the complex
interrelationship between drug factors, host factors, and pathogen factors in the treatment
of an infectious disease. The pharmacokinetics of a drug are encapsulated in the elimination
and toxicity arm of the triangle, and the pharmacodynamics of a drug are encapsulated in
the impairment-destruction and resistance-response arm.
De video's onder "Design of Dosing Regimens for Animals" zijn uitstekende opfrissers van
fundamentele farmacologische kennis. Deze video's zijn beter te bekijken op YouTube met
ondertiteling:
https://www.youtube.com/watch?v=Tsp9t3D2TL0
https://www.youtube.com/watch?v=KkS8H9EeS5I
c. Bekijk onderstaande 7 kennisclips ter voorbereiding van het interactieve hoorcollege
Antibiotica PK/PD en Antibioticabeleid (Antimicrobial Stewardship). Tijdens het college is het
vooral de bedoeling met vragen stellen en discussie over deze begrippen heel helder te
krijgen! Klik op de links om de clips te bekijken. In de powerpointpresentaties kun je de
afzonderlijke slides ook in BrightSpace bekijken (dus geen ss gemaakt maar verwijzing naar
dia’s)
- Vul voor jezelf dit Excel bestand in -> zie Excel bestand ‘tabel antibiotica IC3 MI Ma1
P1’
, 1. PK/PD kennisclip De antibiotica-evenwichtsoefening (7 min)
-
Tijdsafh zoals penicilline -> conc zo lang mogelijk op MIC houden
- Conc afh -> korte krachtige piek hoog boven MIC -> leidt vaak tot minder
bijwerkingen
- AB moet door ADME route
- Penicilline moet bv met pilletje want kan oraal niet door geen abs
- Lipofiele gaan bloed uit, hydrofiel blijft meer in bloed
- MIC = minimale remmende conc = hoe gevoelig bact is voor AB
-
- 2. kennisclip AMS-selectie van resistentie (16 min)
- Bacterien repliceren heel snel waardoor resistentie snel ontstaat
- !! ->
