Summary Last minute revision notes of hematology for 1st year MBBS

, Erythropoiesis
>
-
INTRODUCTION :



·
Process of production of RBCs
.


·
Life span of RBC
-> 120
days
Red cell mas n
26-32mL/kg of body weight
·
.
man -




23-29mL/kgof body weight
> n .
woman > -




>
-
SITES AND
STAGES :



3 misoblastic
stages
· ,


>
Hepatic
Medullary
Mesoblastic
stage
·
:




first in the mesoderm of
during IVL takes
place the
Yolk sac
body
.
-



,

is intravascular
erythropoiesis .
-




Hepatic stage extramedullary erythropoiesis after
·
:



birth is .
abnormal
5th week of gestation always
-




-
takes place in the liver & spleen
.




Medullary stage
·
:




5th month
of IUL
.
-




Bone marrow starts
forming RBCs
.
-




slow in 2nd trimester
-very .


- becomes effective towards the end of 3rd trimester
.


After adolescence is limb bones
eryth
-




regresses
.
.




is limited to
age of evyth.
After the 20-30
yes flat bones
.
-




>
-

STEPS OF ERYTHROPOLESIS :




4 stem cells
major cell
stages
· >


cells
progenitor
-precursor cells
> mature cells
.

·
Red blood cells are formed for pleuripotent hemopoietic stem cells
.

Hemopoietic cells - > committed stem celle >
progenitor cells cells > RBCs
·
>
precursor
- - -