INTESTINES: IBS, CIC, DIVERTICULITIS - PHARM EXAM 1|
TOP SCORES MADE SIMPLE | TRUSTED TEST SOLUTIONS!
IBS And CIC Answer: 2 types of irritable bowel syndrome, most common functional GI
d/o worldwide
not associated w/ abnormal radiologic or endoscopic abnormalities or reliable biomarker
(more of a diagnosis of exclusion)
Rome IV diagnostic criteria for IBS Answer: recurrent abd pain on average at least 1
d/wk in the last 3 months associated with 2 or more of the following criteria:
1. related to defecation
2. associated w/ change in frequency of stool
3. associated w a change in appearance of stool
criteria met x3 months w/ sx onset at least 6 months ago
IBS subtypes Answer: classified by predominant bowel habit (based off of Bristol stool
scale)
IBS-C (w constipation)
IBS-D (w diarrhea)
IBS- M (mixed)
IBS-U (unclassified)
IBS meds Answer: Dicyclomine
Alosetron
Linaclotide
Plecanatide
Lubiprostone
Eluxadoline
Tenapanor
Tricyclic Antidepressants (TCAs)
1
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, dicyclomine (bentyl) MOA Answer: blocks the action of Ach at parasympathetic sites in
smooth muscle, secretory glands, and CNS
dicyclomine (bentyl) SE Answer: dizziness, dry mouth, blurred vision, drowsy, n
(messing w/ Ach - SE)
dicyclomine dosing Answer: provides symptomatic short term relief in IBS, should be a
PRN product
Alosetron (Lotronex) MOA Answer: potent antagonist of 5-HT3; reduces pain,
abdominal discomfort, urgency, and diarrhea
Alosetron (Lotronex) SE Answer: fatigue, headache, n, constipation
Alosetron (Lotronex) concerns Answer: ischemic colitis --> REMS
use is limited to women w/ severe d predominant IBS
Linaclotide (Linzess) MOA Answer: agonist of guanylate cyclase-C which increases
cGMP concentrations and results in chloride and bicarb into the intestines; intestinal
fluid increases; GI transit time decreases
Linaclotide (Linzess) use Answer: used in IBS-C
Linaclotide (Linzess) SE Answer: abd distension, flatulence, d
Plecanatide (Trulance) MOA Answer: agonizes guanylate cyclase-C on the luminal
surface of intestinal epithelium; this increase chloride and bicarb secretions in the
intestinal lumen (compare to linzess)
Plecanatide (Trulance) SE Answer: abd distension, n, d, gas (compare to Linzess)
Plecanatide (Trulance) use Answer: IBS-C
Plecanatide (Trulance) concerns Answer: used in kids (dehydration); not using if we
have a known or suspecetd mechanical GI obstruciton
Lubiprostone (Amitiza) MOA Answer: Cl channel activator that increases intestinal fluid
secretion and intestinal motility
Lubiprostone (Amitiza) concerns Answer: dose adjust in hepatic impairment
Lubiprostone (Amitiza) SE Answer: headahce, n, abd distension, d, flatulence
(compare to Linzess, trulance)
Lubiprostone (Amitiza) use Answer: IBS-C
2
APPHIA - Crafted with Care and Precision for Academic Excellence.
TOP SCORES MADE SIMPLE | TRUSTED TEST SOLUTIONS!
IBS And CIC Answer: 2 types of irritable bowel syndrome, most common functional GI
d/o worldwide
not associated w/ abnormal radiologic or endoscopic abnormalities or reliable biomarker
(more of a diagnosis of exclusion)
Rome IV diagnostic criteria for IBS Answer: recurrent abd pain on average at least 1
d/wk in the last 3 months associated with 2 or more of the following criteria:
1. related to defecation
2. associated w/ change in frequency of stool
3. associated w a change in appearance of stool
criteria met x3 months w/ sx onset at least 6 months ago
IBS subtypes Answer: classified by predominant bowel habit (based off of Bristol stool
scale)
IBS-C (w constipation)
IBS-D (w diarrhea)
IBS- M (mixed)
IBS-U (unclassified)
IBS meds Answer: Dicyclomine
Alosetron
Linaclotide
Plecanatide
Lubiprostone
Eluxadoline
Tenapanor
Tricyclic Antidepressants (TCAs)
1
APPHIA - Crafted with Care and Precision for Academic Excellence.
, dicyclomine (bentyl) MOA Answer: blocks the action of Ach at parasympathetic sites in
smooth muscle, secretory glands, and CNS
dicyclomine (bentyl) SE Answer: dizziness, dry mouth, blurred vision, drowsy, n
(messing w/ Ach - SE)
dicyclomine dosing Answer: provides symptomatic short term relief in IBS, should be a
PRN product
Alosetron (Lotronex) MOA Answer: potent antagonist of 5-HT3; reduces pain,
abdominal discomfort, urgency, and diarrhea
Alosetron (Lotronex) SE Answer: fatigue, headache, n, constipation
Alosetron (Lotronex) concerns Answer: ischemic colitis --> REMS
use is limited to women w/ severe d predominant IBS
Linaclotide (Linzess) MOA Answer: agonist of guanylate cyclase-C which increases
cGMP concentrations and results in chloride and bicarb into the intestines; intestinal
fluid increases; GI transit time decreases
Linaclotide (Linzess) use Answer: used in IBS-C
Linaclotide (Linzess) SE Answer: abd distension, flatulence, d
Plecanatide (Trulance) MOA Answer: agonizes guanylate cyclase-C on the luminal
surface of intestinal epithelium; this increase chloride and bicarb secretions in the
intestinal lumen (compare to linzess)
Plecanatide (Trulance) SE Answer: abd distension, n, d, gas (compare to Linzess)
Plecanatide (Trulance) use Answer: IBS-C
Plecanatide (Trulance) concerns Answer: used in kids (dehydration); not using if we
have a known or suspecetd mechanical GI obstruciton
Lubiprostone (Amitiza) MOA Answer: Cl channel activator that increases intestinal fluid
secretion and intestinal motility
Lubiprostone (Amitiza) concerns Answer: dose adjust in hepatic impairment
Lubiprostone (Amitiza) SE Answer: headahce, n, abd distension, d, flatulence
(compare to Linzess, trulance)
Lubiprostone (Amitiza) use Answer: IBS-C
2
APPHIA - Crafted with Care and Precision for Academic Excellence.
