What is Dose-Response? correct answers Based on action-effect describing toxic effect
(response) based on the amount of toxin (dose).
What are human doses commonly measured in? correct answers PPM and PPB
ED 50 correct answers Dose at which 50% of subjects experience effects
LD 50 correct answers Dose at which 50% of subjects die.
What are the kinds of Hazard Identification? correct answers Human Reports, Animal Studies,
and Read-Across Predicitions
Types of Human Reports correct answers Medical Reports, Anecodtal Reports, and
Epidemiological Studies
Why are Animal Studies Important? correct answers They help determine the ratio between the
benefical dose and the toxic dose of medications.
Medical Reports correct answers Documenting the effects a person has following exposure
Anecdotal Reports correct answers Information gathered through stories/word-of-mouth.
Contains heavy bias.
Epidemiological Studies correct answers Foundation of disease control through tracking
prevalence, natural history, and identifying determinants or causes
, Read-Across Predictions correct answers Using similar atomic structures to predict the outcomes
of other compounds.
Example of Read-Across Predicitions? correct answers Many organic chlorinated compounds are
carcinogenic, which is logical since their structure is similar and they would have similar
properties.
CNS Effects correct answers Anything that effects the brain and causes reversible or irreverisble
irritation: Such as motor skills, reasoning, mental clairty, headaches, confusion and loss of nerve
function.
Factors That Affect Toxicity correct answers Form of the substance, Dosage, Route of exposure,
Species, Life Stage, Absorption of Toxicant, Metabolism, Distribution/Excretion from the Body,
Health of the Individual, and Co-exposures.
NOAELs correct answers Highest exposure where no people experienced any negative health
outcomes.
LOAELs correct answers Exposure where people first experienced negative health outcomes.
Positive Control correct answers An experimental treatment which results in the desired effect.
Negative Control correct answers An experimental treatment which does not result in the desired
effect.
Health Effects of Carbon Nanotubes (CNTs) correct answers Have similar, or even more toxic,
health outcomes when compared to asbestos.
Bulk Materials correct answers Generally have to consider the state of matter.