PCB 3233 Ch 9 practice university of central florida
Part 1: Antibody Functions and Structure
1. Which region of an antibody determines its effector function?
o A) Variable region
o B) Hinge region
o C) Constant region
o D) Antigen-binding site
2. What is the primary function of antibodies in neutralization?
o A) Marking pathogens for destruction by immune cells
o B) Preventing pathogens or toxins from interacting with host cells
o C) Activating the complement system
o D) Sensitizing mast cells and basophils
3. Which antibody isotype is most involved in opsonization?
o A) IgM
o B) IgA
o C) IgE
o D) IgG
4. ADCC involves all of the following EXCEPT:
o A) NK cells
o B) Release of cytotoxic granules
o C) IgE antibodies
o D) Fcγ receptors
5. The gold standard for vaccination aims to:
o A) Activate complement pathways
o B) Generate neutralizing antibodies
o C) Sensitize mast cells
o D) Promote ADCC
Part 2: B-cell Development and Activation
6. T follicular helper (Tfh) cells are crucial for:
o A) Plasma cell differentiation
o B) Isotype switching
, o C) B-cell activation
o D) All of the above
7. Where are B-1 cells predominantly located?
o A) Lymph nodes
o B) Spleen
o C) Peritoneal and pleural cavities
o D) Bloodstream
8. The minimum number of BCRs needed for receptor clustering is:
o A) 1
o B) 2
o C) 4
o D) 6
9. Which component of the BCR signaling cascade activates ITAMs?
o A) Igα/Igβ
o B) PLC-γ
o C) Src-family kinases
o D) Syk
10. What is the primary function of the B-cell co-receptor's CR2 component?
o A) Stabilizing the BCR
o B) Binding to C3d on pathogens
o C) Signaling amplification
o D) Antigen internalization
Part 3: Germinal Center and Isotype Switching
11. Somatic hypermutation occurs in the:
o A) Dark zone
o B) Light zone
o C) Primary focus
o D) Medullary cords
12. Centrocytes are tested against antigens in the:
o A) Dark zone
Part 1: Antibody Functions and Structure
1. Which region of an antibody determines its effector function?
o A) Variable region
o B) Hinge region
o C) Constant region
o D) Antigen-binding site
2. What is the primary function of antibodies in neutralization?
o A) Marking pathogens for destruction by immune cells
o B) Preventing pathogens or toxins from interacting with host cells
o C) Activating the complement system
o D) Sensitizing mast cells and basophils
3. Which antibody isotype is most involved in opsonization?
o A) IgM
o B) IgA
o C) IgE
o D) IgG
4. ADCC involves all of the following EXCEPT:
o A) NK cells
o B) Release of cytotoxic granules
o C) IgE antibodies
o D) Fcγ receptors
5. The gold standard for vaccination aims to:
o A) Activate complement pathways
o B) Generate neutralizing antibodies
o C) Sensitize mast cells
o D) Promote ADCC
Part 2: B-cell Development and Activation
6. T follicular helper (Tfh) cells are crucial for:
o A) Plasma cell differentiation
o B) Isotype switching
, o C) B-cell activation
o D) All of the above
7. Where are B-1 cells predominantly located?
o A) Lymph nodes
o B) Spleen
o C) Peritoneal and pleural cavities
o D) Bloodstream
8. The minimum number of BCRs needed for receptor clustering is:
o A) 1
o B) 2
o C) 4
o D) 6
9. Which component of the BCR signaling cascade activates ITAMs?
o A) Igα/Igβ
o B) PLC-γ
o C) Src-family kinases
o D) Syk
10. What is the primary function of the B-cell co-receptor's CR2 component?
o A) Stabilizing the BCR
o B) Binding to C3d on pathogens
o C) Signaling amplification
o D) Antigen internalization
Part 3: Germinal Center and Isotype Switching
11. Somatic hypermutation occurs in the:
o A) Dark zone
o B) Light zone
o C) Primary focus
o D) Medullary cords
12. Centrocytes are tested against antigens in the:
o A) Dark zone
