University of Ottawa
Blood Physiology Multiple Choice Questions
(Comprehensive Review of Blood Composition, Function, and Disorders)
Course: ANP 1105C
, ANP 1105C Blood Physiology Multiple Choice
Questions
Comprehensive Review of Blood Composition, Function,
and Disorders
Questions:
1. Which plasma protein contributes most to plasma osmotic pressure (colloid
osmotic/oncotic pressure) and helps prevent edema by holding water inside blood
vessels?
A) Globulins
B) Fibrinogen
C) Albumin
D) Transferrin
Answer: C) Albumin
Explanation: Albumin is the most abundant plasma protein (60% of total plasma proteins)
and is primarily responsible for maintaining colloid osmotic pressure, which keeps fluid
within the blood vessels and prevents edema.
2. What is the normal pH range of human blood?
A) 7.0-7.2
B) 7.35-7.45
C) 7.5-7.8
D) 6.8-7.0
Answer: B) 7.35-7.45
*Explanation: Blood pH is tightly regulated between 7.35-7.45, which is slightly alkaline.
Deviations outside this range can indicate acidosis or alkalosis.*
, 3. Which of the following characteristics of erythrocytes specifically enhances their
efficiency for gas transport?
A) Presence of mitochondria for ATP production
B) Nucleus for protein synthesis
C) Biconcave shape and absence of mitochondria
D) Rough endoplasmic reticulum for hemoglobin production
Answer: C) Biconcave shape and absence of mitochondria
Explanation: The biconcave shape provides a large surface area for gas exchange, while
the absence of mitochondria ensures that oxygen carried by hemoglobin is not used by the
cell itself (anaerobic ATP production).
4. What is the primary function of the cytoskeletal protein spectrin in
erythrocytes?
A) Oxygen binding
B) Cell shape maintenance and stability
C) Carbon dioxide transport
D) Iron storage
Answer: B) Cell shape maintenance and stability
Explanation: Spectrin forms a network on the inner surface of the plasma membrane that
maintains the biconcave shape, provides stability, and organizes transmembrane proteins.
5. Hemoglobin consists of which of the following components?
A) Four polypeptide chains and four heme groups with Fe2+
B) Two polypeptide chains and two heme groups with Fe3+
C) Six polypeptide chains and four heme groups with Fe2+
D) Four polypeptide chains and two heme groups with Mg2+
Answer: A) Four polypeptide chains and four heme groups with Fe2+
*Explanation: Hemoglobin contains four polypeptide chains (2 alpha and 2 beta chains)
and four heme groups, each with an Fe2+ ion that reversibly binds one oxygen
molecule.*