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Family Medicine COMAT (NBOME COMAT-FM) – 400 Questions – Primary Care, Pediatrics, OB/GYN, Internal Medicine Q&A 2026

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This document is a comprehensive collection of approximately 400 high-yield Family Medicine COMAT-style questions and expert-verified answers, designed to optimize rapid recall, clinical reasoning, and exam readiness. It covers a broad spectrum of primary care topics including internal medicine, pediatrics, obstetrics and gynecology, cardiology, endocrinology, infectious diseases, dermatology, psychiatry, and preventive medicine. Early sections (pages 1–10) emphasize foundational concepts such as NYHA heart failure classification, hyperparathyroidism complications (e.g., brown tumors), BMI classifications, atypical pneumonia management, and screening guidelines (e.g., AAA ultrasound), while later sections expand into advanced clinical scenarios including stroke localization, asthma severity classification, diabetes diagnostics, and chronic disease management. The document integrates high-yield clinical associations, diagnostic criteria, and evidence-based treatment strategies essential for COMAT and board exams. It includes detailed coverage of common outpatient conditions such as hypertension, diabetes, COPD, asthma, osteoarthritis, and GERD, as well as preventive care guidelines (e.g., cancer screening, vaccination schedules, prenatal screening timelines). Additionally, it highlights critical exam topics such as infectious disease management (e.g., CAP treatment, TB testing with Quantiferon), women’s health (e.g., mastitis, contraception, pregnancy care), pediatrics (e.g., developmental milestones, bronchiolitis, congenital disorders), and emergency presentations (e.g., CVA, lead poisoning, anaphylaxis). The structured Q&A format supports active recall, spaced repetition, and efficient final-stage revision. This resource is highly relevant for courses such as Family Medicine Clerkship, Primary Care Medicine, Internal Medicine, Pediatrics, Obstetrics & Gynecology, and Preventive Medicine. It is ideal for osteopathic medical students (DO programs) preparing for the Family Medicine COMAT exam (NBOME), as well as students preparing for COMLEX Level 2-CE and USMLE Step 2 CK. It is also suitable for physician assistant (PA) students, nursing students, and international medical graduates seeking a comprehensive primary care review. The content aligns closely with widely used board preparation textbooks such as First Aid for the USMLE Step 2 CK, Step-Up to Medicine, and COMAT review resources, making it a powerful supplementary tool for consolidating high-yield knowledge, improving diagnostic accuracy, and maximizing exam performance. Keywords: family medicine, COMAT exam, primary care, internal medicine, pediatrics, obstetrics, gynecology, preventive medicine, cardiology, endocrinology, infectious disease, hypertension, diabetes, asthma, COPD, screening guidelines, vaccination, clinical questions, board exam preparation

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Family Medicine COMAT 2026
Expert Verified | Ace the Test



NYHA classification - 🧠 ANSWER ✔✔Class I - No sx


Class II - symptoms with vigorous physical activity

Class III - symptoms with ADLs

Class IV - symptoms at rest

what is a rare symptom that can occur with primary hyperparathyroidism ? -

🧠 ANSWER ✔✔brown tumors - osteitis fibrosa cystica - cystic bone spaces

filled with brown fibrous tissue

,main symptoms is hypercalcemia - bones, stones, abdominal groans, and

psychiatric overtones

-see inc PTH and Ca and low phosphate




tidbit - secondary hyperPTH will result from chronic renal disease. Causes

hypovitaminosis D and hyperphosphatemia in chronical renal dz leading to

*HYPOCALCEMIA* - trousseaus and chovstek


ABI for PAD - 🧠 ANSWER ✔✔0.9 or less


BMI classifications - 🧠 ANSWER ✔✔normal - <18.5-24.9


overweight - 25-29.9

Obese - >30

obese class 1 - 30-34.9

class II - 35-35.9

morbid obese - >40


Walking pneumonia symptoms - 🧠 ANSWER ✔✔Gradual onset

,Fever, headache, myalgia and fatigue




After a few days, develop a dry cough that may or may not produce sputum

later on

-pleuritic chest pain




Can persist for two weeks or more




usually will see peribronchial pneumonia with reticulonodular infiltrates


Treatment of atypical pneumonia and why - 🧠 ANSWER ✔✔usually its due

to mycoplasma pneumonia or chlamydophila

-mycoplasma lacks a cell wall so it is useless to treat with beta lactams that

target a cell wall

-better to treat with macrolides such azithromycin


when should you screen for AAA? - 🧠 ANSWER ✔✔With an U/S at the age

of 65 in all men with a smoking Hx

COPYRIGHT©PROFFKERRYMARTIN 2025/2026. YEAR PUBLISHED 2026. COMPANY REGISTRATION NUMBER: 619652435. TERMS OF USE.
PRIVACY STATEMENT. ALL RIGHTS RESERVED

, -No repeat if U/S is normal




any man with a smoking history from 65-75 should receive an abdominal

US


what drugs can lead to overflow incontinence - 🧠 ANSWER ✔✔calcium

channel blockers

what exams and labs should you get with incontinence - 🧠 ANSWER

✔✔pelvic and rectal exam in males




important to get a UA to rule out UTI and PSA in males as well

what is first line pharm tx for urge incontinence? what is a common side

effect with this medication? what can you switch to? - 🧠 ANSWER ✔✔1.

first line is behavioral modifications and exercises

2. if fails, use oxybutynin (muscarinic antagonist)

3. dry mouth is a common side effect, if it occurs too much, can use

*tolterodine*

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