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OBGYN COMAT (NBOME) – 400 Questions – Pregnancy, Preeclampsia, Gynecologic Oncology, Obstetrics Q&A 2026

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This document is a comprehensive OBGYN COMAT preparation resource containing approximately 400 high-yield clinical questions and answers covering obstetrics, gynecology, reproductive endocrinology, and women’s health. It includes essential topics such as pregnancy management, prenatal screening, labor and delivery complications, gynecologic cancers, infertility, and hormonal disorders. Early sections (pages 1–3) focus on foundational concepts like endometrial hyperplasia, ovarian cancer risk factors (e.g., BRCA, Lynch syndrome), and prenatal laboratory testing, while later sections expand into complex clinical scenarios including preeclampsia with severe features, HELLP syndrome, ectopic pregnancy management, and twin-to-twin transfusion syndrome. The document integrates high-yield diagnostic criteria, treatment algorithms, and clinical pearls critical for COMAT and board exam success. It covers key obstetric emergencies such as placental abruption, postpartum hemorrhage, amniotic fluid embolism, and chorioamnionitis, along with detailed gynecologic pathology including ovarian tumors (e.g., granulosa cell tumors, teratomas), endometrial disorders, and breast conditions. Preventive care and screening guidelines are emphasized, including cervical cancer screening, mammography recommendations, and prenatal testing timelines. Additionally, it highlights pharmacologic management (e.g., methotrexate for ectopic pregnancy, magnesium sulfate for eclampsia, progesterone therapy) and important clinical frameworks such as biophysical profile scoring, fetal heart rate interpretation, and labor progression criteria. This resource is highly relevant for courses such as Obstetrics and Gynecology Clerkship, Women’s Health, Reproductive Medicine, and Clinical Medicine. It is ideal for osteopathic medical students preparing for the NBOME OBGYN COMAT exam, as well as students preparing for COMLEX Level 2-CE and USMLE Step 2 CK. It is also suitable for physician assistant (PA) students, nursing students, and international medical graduates seeking a comprehensive and exam-focused review of OBGYN topics. The content aligns closely with widely used board preparation textbooks such as First Aid for the USMLE Step 2 CK, Case Files Obstetrics and Gynecology, and Blueprints Obstetrics & Gynecology, making it a valuable supplementary resource for reinforcing high-yield concepts, improving clinical reasoning, and maximizing exam performance. Keywords: OBGYN COMAT, obstetrics, gynecology, pregnancy, preeclampsia, HELLP syndrome, ectopic pregnancy, prenatal screening, labor and delivery, gynecologic oncology, ovarian tumors, infertility, contraception, postpartum complications, fetal monitoring, board exam preparation

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OBGYN COMAT 2026 EXAM
QUESTIONS AND ANSWERS |
100% PASS


Pregnancies and OCPs _____ the risk of surface epithelial cancer of

ovaries - 🧠 ANSWER ✔✔decrease


A patient presents with uterine bleeding and a precancerous endometrial

biopsy

Suspected diagnosis:

,Treatment: High-dose progesterone - 🧠 ANSWER ✔✔Endometrial

hyperplasia

A patient presents with uterine bleeding and a precancerous endometrial

biopsy

Suspected diagnosis: endometrial hyperplasia


Treatment: - 🧠 ANSWER ✔✔High-dose progesterone


What are the two genetic conditions associated with increased risk of

surface epithelial cell tumors? - 🧠 ANSWER ✔✔BRCA1/2


:Lynch syndrome

A patient presents with uterine bleeding and a cancerous endometrial

biopsy. What is the suspected diagnosis and corresponding treatment? - 🧠

ANSWER ✔✔dx: Adenocarcinoma, Tx: total abdominal hysterectomy,

bilateral salpingo-oophorectomy

If a pre-menstrual female presents with an adnexal mass it is likely what?

what is the corresponding treatment? - 🧠 ANSWER ✔✔germ cell tumor,

unilateral salpingo-oophorectomy

,If a post-menopausal presents with an adnexal mass it is likely what? - 🧠

ANSWER ✔✔epithelial tumor


Routine prenatal labs at initial prenatal visits - 🧠 ANSWER ✔✔Rh D type

and antibody, H/H, HIV, VDRL/RPR, HBsAg, MCV, ferritin, anti-HCV ab,

Rubella, and varicella, urine culture, urine dipstick for protein, chlamydia

PCR is risk factors are present, pap test

if fetal presentation is indeterminate on cervical exam due to a bulging

amniotic sac or high fetal station then what should be performed? - 🧠

ANSWER ✔✔transabdominal US to confirm presentation which is

necessary to determine the route of delivery


Twin-twin transfusion syndrome - 🧠 ANSWER ✔✔monozygotic twin

pregnancy with single placenta and arteriovenous shunt within the placenta

patients with an ectopic pregnancy have no what on exam of the

intrauterine contents? - 🧠 ANSWER ✔✔no chorionic villi


severe features of preeclampsia - 🧠 ANSWER ✔✔-BP of >160 systolic,

>110 diastolic

-Thrombocytopenia <100k platelets



COPYRIGHT©PROFFKERRYMARTIN 2025/2026. YEAR PUBLISHED 2026. COMPANY REGISTRATION NUMBER: 619652435. TERMS OF USE.
PRIVACY STATEMENT. ALL RIGHTS RESERVED

, -Impaired liver function (elevated transaminases)

-Renal insufficiency, creatinine >1.1 or 2x normal

-Pulmonary edema

-Cerebral or visual disturbances


what causes the RUQ pain in pt's with HELLP? - 🧠 ANSWER ✔✔distention

of the glisson capsule


pubic symphysis diastasis - 🧠 ANSWER ✔✔Occurs after traumatic delivery




Presents w/:

Radiating suprapubic pain that is exacerbated by ambulation or weight

bearing

ex: difficulty walking the day after delivery




Tx: supportive care


femoral neuropathy after delivery - 🧠 ANSWER ✔✔occurs during delivery

as a result of hyperflexion of the thigh. It presents with numbness over the

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