Quiz 8: Therapeutic Drug Monitoring
(TDM) Question and answers correctly
solved 2025/2026
Chem 471 Notes: - correct answer ✔
Chem 481 Study Guide: - correct answer ✔
What is therapeutic drug monitoring? Define half-life. Define steady state. - correct answer ✔A process
of determining the quantity of a therapeutic drug required to produce a predetermined desirable effect.
Half-life: time required for the concentration of a drug to be decreased by one half.
Steady State: reached when the amount of drug in the dose given is sufficient only to replace the
amount of drug eliminated since the last dose. Can be measured after 5 drug half-lives because then the
blood will have reached 97% of the steady state.
Define the following terms related to therapeutic drug monitoring:
1. Compartment
2. First Order Kinetics
3. Peak Concentration - correct answer ✔1. specific place in the body where a drug is present (e.g.
plasma, tissue).
2. rate of metabolism is dependent on the concentration of the substrate.
3. highest concentration of drug measured in the blood.
Collection time varies based on the absorption of the drug.
Define the following terms related to therapeutic drug monitoring:
4. Therapeutic Range
, 5. Trough Concentration - correct answer ✔4. concentrations between the minimum effective
concentration and
the minimum toxic concentration.
5. lowest concentration of a drug measured in the blood
Collection is usually immediately prior to the administration of the
next dose
Name the five step process that takes place when a therapeutic agent is administered to a patient. -
correct answer ✔1. Liberation (release of the drug)
2. Absorption - drug taken into the body enters the blood
3. Distribution - drug must be translocated to its= site of action (via the blood)
4. Metabolism (biotransformation) - occurs mainly in the liver. Unmetabolized drug is a parent
compound, products of metabolism are metabolites (metabolites increase, decrease or do not change
activity of the drug
5. Excretion - if drug is water-soluble or can be rendered water soluble through metabolism, it is
eliminated through the urine.
Name the classification of the following therapeutic drugs, NTR (normal therapeutic range-include
units), and trade name for each.
1. Theophylline - correct answer ✔1. Trade: Aminophylline.
Class H: Bronchodilator-antagonist against adenosine so muscles are relaxed
Name the classification of the following therapeutic drugs, NTR (normal therapeutic range-include
units), and trade name for each.
2. Quinidine - correct answer ✔2. Trade: Quinaglute, Quinidex. NTR: 2-5 ug/mL
Class E: Anti-arrhythmic (cardioactive)-reduces cardiac excitability
Name the classification of the following therapeutic drugs, NTR (normal therapeutic range-include
units), and trade name for each.
(TDM) Question and answers correctly
solved 2025/2026
Chem 471 Notes: - correct answer ✔
Chem 481 Study Guide: - correct answer ✔
What is therapeutic drug monitoring? Define half-life. Define steady state. - correct answer ✔A process
of determining the quantity of a therapeutic drug required to produce a predetermined desirable effect.
Half-life: time required for the concentration of a drug to be decreased by one half.
Steady State: reached when the amount of drug in the dose given is sufficient only to replace the
amount of drug eliminated since the last dose. Can be measured after 5 drug half-lives because then the
blood will have reached 97% of the steady state.
Define the following terms related to therapeutic drug monitoring:
1. Compartment
2. First Order Kinetics
3. Peak Concentration - correct answer ✔1. specific place in the body where a drug is present (e.g.
plasma, tissue).
2. rate of metabolism is dependent on the concentration of the substrate.
3. highest concentration of drug measured in the blood.
Collection time varies based on the absorption of the drug.
Define the following terms related to therapeutic drug monitoring:
4. Therapeutic Range
, 5. Trough Concentration - correct answer ✔4. concentrations between the minimum effective
concentration and
the minimum toxic concentration.
5. lowest concentration of a drug measured in the blood
Collection is usually immediately prior to the administration of the
next dose
Name the five step process that takes place when a therapeutic agent is administered to a patient. -
correct answer ✔1. Liberation (release of the drug)
2. Absorption - drug taken into the body enters the blood
3. Distribution - drug must be translocated to its= site of action (via the blood)
4. Metabolism (biotransformation) - occurs mainly in the liver. Unmetabolized drug is a parent
compound, products of metabolism are metabolites (metabolites increase, decrease or do not change
activity of the drug
5. Excretion - if drug is water-soluble or can be rendered water soluble through metabolism, it is
eliminated through the urine.
Name the classification of the following therapeutic drugs, NTR (normal therapeutic range-include
units), and trade name for each.
1. Theophylline - correct answer ✔1. Trade: Aminophylline.
Class H: Bronchodilator-antagonist against adenosine so muscles are relaxed
Name the classification of the following therapeutic drugs, NTR (normal therapeutic range-include
units), and trade name for each.
2. Quinidine - correct answer ✔2. Trade: Quinaglute, Quinidex. NTR: 2-5 ug/mL
Class E: Anti-arrhythmic (cardioactive)-reduces cardiac excitability
Name the classification of the following therapeutic drugs, NTR (normal therapeutic range-include
units), and trade name for each.
