Santangelo Research correct answers development of imaging probes and technology for the
study of RNA regulation and pathogenesis of RNA viruses
Santangelo Lab of Spatial Biology correct answers PET/CT contrast agents for detecting
SIV/SHIV and immune cell localization with macque model, mRNA based therapeutics, Human
RSV and Marburg/Ebola Replication
mRNA based therpeutics correct answers for fighting influenza, gene editors and anti-CRISPRS,
and tools for interrogating mRNA delivery in mice (lungs)
synthetic mRNA correct answers safe way of performing gene therapy- transient, non-
integrating, and low immunogenicity
Evolution of RNA imaging tools correct answers single molecule imaging of RNA, detection of
RNA protein interaction using probes, development of activeable RNA probes, designs used as
part of mRNA-based vaccine strategies
hRSV correct answers most common cause of bronchiolitis and pneumonia among infants and
children
macaques correct answers iv injection of Cu64 because ART does not clear the virus, just
prevents it
nature of life correct answers variety in details, consistency in fundamentals
diversity correct answers observed at the organism and the cell level, cell specialization is an
integral part, consistency in composition and organization
heredity correct answers distinguishes life from other processes, passed on via cell division from
a single cell, single cell is vehicle for hereditary information
,hereditary info correct answers stored in the form of double stranded DNA, long polymers
formed from four nucelotides
nucleotide correct answers sugar, phosphate, base
DNA synthesis correct answers synthesized from preexisting DNA via complementary base
pairing and hydrogen bonds, A to T and G to C and the creation of phosphodiester bonds or
polymerization
information expressed by correct answers transcription of RNA, ribonucleic acids, and then
through translation of RNA
translation correct answers process by which RNA is used as a template for protein synthesis
transcripts correct answers mostly are messenger RNA, which code for proteins
proteins correct answers polymers of amino acids or polypeptides, function is defined by their
3D shapes, creating reactive regions, many act as enzymes to catalyze specific reactions
gene correct answers segment of DNA sequence corresponding to a single proteins or to a non-
coding RNA
Gene expression correct answers regulated through: stretches of regulatory DNA, DNA and
chromatin modifications, post-transcriptional regulation
cells correct answers dynamic chemical systems, far from equilibrium, cells make and consume
ATP, energy released through hydrolysis of ATP
eukaryotes correct answers all have nucleus
, nuclear envelope correct answers separates the nucleoplasm from the cytoplasm
chromosomes correct answers 46, carry the cells genes within the nucleus, which also contains
the machinery for gene expression. Prokaryotes have DNA in the cytoplasm
endoplasmic reticulum correct answers major site of protein and phospholipid synthesis
golgi apparatus correct answers sugars added to membrane proteins, lysosomal proteins, and
secretory proteins
lysosomes correct answers compartment for digestive enzymes
peroxisomes correct answers container for enzymes involved in oxidation
mitochondira correct answers convert energy stores in chemical bonds in nutrients into ATP,
apoptosis, innate immunity
cilia correct answers used for motility and sensing
epithelium correct answers tissue composed of cells that line the cavities and surfaces of
structures, polyhedral, skin, GI tract, lungs, glands
endothelium correct answers tissue composed of cells of the inner lining of blood vessels, the
heart, and lymphatic vessels
nervous correct answers motory, sensory, autonomic
muslce correct answers connect together to form the long fibers in muscles