QUESTIONS AND ANSWERS WITH COMPLETE
SOLUTIONS LATEST UPDATE
Peptic Ulcer Disease Umbrella term for varying degrees of
erosion in GI wall, often in stomach or
duodenum
Most common cause of Gram negative bacteria called H. pylori
peptic ulcer disease
Most common cause of Long term/large doses of NSAID
peptic ulcer disease in
people without H. pylori
Protective factors in stomach Mucus, bicarbonate, prostaglandin,
antioxidant enzymes, submucosal blood
flow
,Aggressive factors in H. pylori, NSAIDs, gastric acid, oxidative
stomach stress, smoking
Pathogenesis of Peptic Ulcer Imbalance between defensive and
Disease aggressive factors
Noninvasive H. pylori test Breath test, Serologic, Stool
Breath Test for H. pylori Patient receives radiolabeled urea, test is
positive if it is converted into CO2 and
ammonia and CO2 is present in
breath
Most common antibiotics for Clarithromycin
H. Pylori
3 multiple choice options
Bismuth subsalicyte affect For H.
pylori
Disrupts
cell wall
Inhibits urease activity
, Prevents bacteria from adhering to
gastric wall
Bismuth subsalicyte adverse Black tongue and stool
reaction
Antibiotic therapy for H. 2+ antibiotics combined with PPI or H2RA
pylori
Reasons for H. pylori Multiple pills
antibiotic treatment several times a
noncompliance day Multiple
adverse effects
Expensive
Clarithromycin triple therapy For h. pylori patients without penicillin
1 and low resistance to clarithromycin.
Clarithromycin + amoxicillin + PPI
Clarithromycin triple therapy For h. pylori patients with
2 penicillin allergy
Clarithromycin +
metronidazole + PPI