NR 507 CNS Disorders and Management Exam 2026 |Chamberlain
1. Which neurotransmitter deficiency is primarily associated with the motor
symptoms of Parkinson’s disease?
A. Serotonin
B. Norepinephrine
C. Acetylcholine
D. Dopamine
Answer: D
Rationale: Parkinson’s disease is characterized by the degeneration of dopaminergic
neurons in the substantia nigra, leading to a deficiency of dopamine in the basal ganglia.
2. In the pathophysiology of Alzheimer’s Disease, which protein forms
extracellular aggregates known as neuritic plaques?
A. Amyloid-beta
B. Huntingtin
C. Alpha-synuclein
D. Tau protein
Answer: A
Rationale: Alzheimer’s disease involves the accumulation of amyloid-beta plaques
extracellularly and tau protein tangles intracellularly.
,3. A patient presents with sudden weakness on one side of the body and
difficulty speaking. If the symptoms resolve completely within 24 hours, the
event is classified as:
A. Transient Ischemic Attack (TIA)
B. Hemorrhagic Stroke
C. Ischemic Stroke
D. Reversible Ischemic Neurological Deficit
Answer: A
Rationale: A TIA is a brief episode of neurological dysfunction caused by focal brain or
retinal ischemia, with clinical symptoms typically lasting less than one hour and without
evidence of acute infarction.
4. Multiple Sclerosis (MS) is characterized by which of the following
pathophysiological processes?
A. Degeneration of lower motor neurons
B. Autoimmune-mediated demyelination of the CNS
C. Depletion of acetylcholine at the neuromuscular junction
D. Accumulation of Lewy bodies in the brainstem
Answer: B
Rationale: MS is a chronic inflammatory disease where the immune system attacks the
myelin sheath of neurons in the Central Nervous System (CNS).
5. Cushing’s Triad is a clinical indicator of increased intracranial pressure (ICP).
What are its three components?
A. Bradycardia, Hypertension with widening pulse pressure, Irregular respirations
B. Tachycardia, Hypertension, Tachypnea
C. Hypotension, Bradycardia, Cheyne-Stokes respirations
D. Tachycardia, Hypotension, Shallow breathing
Answer: A
, Rationale: Cushing’s triad consists of bradycardia, hypertension (specifically a widening
pulse pressure), and irregular respirations (such as Cheyne-Stokes), signaling late-stage
increased ICP.
6. Which of the following is the most common cause of bacterial meningitis in
adults?
A. Neisseria meningitidis
B. Haemophilus influenzae
C. Streptococcus pneumoniae
D. Listeria monocytogenes
Answer: C
Rationale: Streptococcus pneumoniae is currently the leading cause of bacterial meningitis
in adults in many regions.
7. What is the primary mechanism of injury in Myasthenia Gravis?
A. Autoimmune destruction of acetylcholine receptors at the neuromuscular junction
B. Destruction of dopamine receptors
C. Degeneration of the myelin sheath in the peripheral nervous system
D. Viral infection of the motor neurons
Answer: A
Rationale: Myasthenia Gravis is an autoimmune disorder where antibodies block or
destroy nicotinic acetylcholine receptors at the postsynaptic neuromuscular junction.
8. Which type of seizure involves both hemispheres of the brain from the onset
and usually results in loss of consciousness?
A. Focal aware seizure
B. Focal impaired awareness seizure
C. Simple partial seizure
D. Generalized seizure
Answer: D
1. Which neurotransmitter deficiency is primarily associated with the motor
symptoms of Parkinson’s disease?
A. Serotonin
B. Norepinephrine
C. Acetylcholine
D. Dopamine
Answer: D
Rationale: Parkinson’s disease is characterized by the degeneration of dopaminergic
neurons in the substantia nigra, leading to a deficiency of dopamine in the basal ganglia.
2. In the pathophysiology of Alzheimer’s Disease, which protein forms
extracellular aggregates known as neuritic plaques?
A. Amyloid-beta
B. Huntingtin
C. Alpha-synuclein
D. Tau protein
Answer: A
Rationale: Alzheimer’s disease involves the accumulation of amyloid-beta plaques
extracellularly and tau protein tangles intracellularly.
,3. A patient presents with sudden weakness on one side of the body and
difficulty speaking. If the symptoms resolve completely within 24 hours, the
event is classified as:
A. Transient Ischemic Attack (TIA)
B. Hemorrhagic Stroke
C. Ischemic Stroke
D. Reversible Ischemic Neurological Deficit
Answer: A
Rationale: A TIA is a brief episode of neurological dysfunction caused by focal brain or
retinal ischemia, with clinical symptoms typically lasting less than one hour and without
evidence of acute infarction.
4. Multiple Sclerosis (MS) is characterized by which of the following
pathophysiological processes?
A. Degeneration of lower motor neurons
B. Autoimmune-mediated demyelination of the CNS
C. Depletion of acetylcholine at the neuromuscular junction
D. Accumulation of Lewy bodies in the brainstem
Answer: B
Rationale: MS is a chronic inflammatory disease where the immune system attacks the
myelin sheath of neurons in the Central Nervous System (CNS).
5. Cushing’s Triad is a clinical indicator of increased intracranial pressure (ICP).
What are its three components?
A. Bradycardia, Hypertension with widening pulse pressure, Irregular respirations
B. Tachycardia, Hypertension, Tachypnea
C. Hypotension, Bradycardia, Cheyne-Stokes respirations
D. Tachycardia, Hypotension, Shallow breathing
Answer: A
, Rationale: Cushing’s triad consists of bradycardia, hypertension (specifically a widening
pulse pressure), and irregular respirations (such as Cheyne-Stokes), signaling late-stage
increased ICP.
6. Which of the following is the most common cause of bacterial meningitis in
adults?
A. Neisseria meningitidis
B. Haemophilus influenzae
C. Streptococcus pneumoniae
D. Listeria monocytogenes
Answer: C
Rationale: Streptococcus pneumoniae is currently the leading cause of bacterial meningitis
in adults in many regions.
7. What is the primary mechanism of injury in Myasthenia Gravis?
A. Autoimmune destruction of acetylcholine receptors at the neuromuscular junction
B. Destruction of dopamine receptors
C. Degeneration of the myelin sheath in the peripheral nervous system
D. Viral infection of the motor neurons
Answer: A
Rationale: Myasthenia Gravis is an autoimmune disorder where antibodies block or
destroy nicotinic acetylcholine receptors at the postsynaptic neuromuscular junction.
8. Which type of seizure involves both hemispheres of the brain from the onset
and usually results in loss of consciousness?
A. Focal aware seizure
B. Focal impaired awareness seizure
C. Simple partial seizure
D. Generalized seizure
Answer: D
