Latest Update 2026
Variolation inoculation of smallpox into skin (18th century)
Discovered the small pox vaccine and process of
Edward Jenner
vaccination
Administration of antigens to induce antibody
Active immunization
and memory cell production
Weakened pathogens
Mildly infectious
Attenuated (live) vaccines No boosters
Provide contact immunity
Ex. Measles
Whole or subunits
Safer
Inactivated (killed) vaccines
Need boosters
Humoral immunity
Have bacteria but not it's toxins
Chemically or thermally modified
Active and humoral immunity
Toxoid vaccines
Useful on bacteria
Need boosters
Ex. Tetanus
Administers antigens from several pathogens at
Combination vaccines
the same time
, Resemble intact virus
No genetic material
Viral like particle vaccines (VLP)
Only viral coat is fought off
Ex. HPV