Test Bank For Rapid Review Pharmacology, 3rd Edition
With STUDENT CONSULT Online Access
Authors : Thomas L. Pazdernik & Laszlo Kerecsen
, Rapid Review Pharmacology, 3rd Edition
Chapter 1: Pharmacokinetics.
Q1.
A drug with high lipid solubility and low molecular weight is most likely to:
A. Be poorly absorbed orally
B. Cross cell membranes easily
C. Be rapidly excreted unchanged
D. Have low bioavailability
E. Be restricted to plasma
Answer: B
Explanation:
• Lipid-soluble, small molecules cross membranes via passive diffusion.
Mechanism: Passive diffusion down concentration gradient
Clinical Correlation: CNS drugs must be lipid-soluble to cross BBB
Why others are wrong:
• A: Opposite—lipid solubility ↑ absorption
• C: Lipophilic drugs require metabolism
• D: Bioavailability usually ↑
• E: Hydrophilic drugs stay in plasma
Q2.
First-pass metabolism primarily occurs in the:
A. Kidney
B. Lung
C. Liver
, D. Brain
E. Plasma
Answer: C
Explanation:
• Portal circulation delivers drugs to liver → metabolism before systemic circulation
Mechanism: Hepatic enzyme degradation (CYP450)
Clinical Correlation:
• Oral drugs like propranolol have ↓ bioavailability
Incorrect options:
• A/B/D/E: Not major first-pass sites
Q3.
Which parameter best reflects drug distribution?
A. Clearance
B. Volume of distribution
C. Half-life
D. Bioavailability
E. Absorption rate
Answer: B
Explanation:
• Vd = amount of drug in body / plasma concentration
Mechanism: Indicates tissue vs plasma distribution
Clinical Correlation:
• High Vd → tissue binding (e.g., digoxin)
Incorrect:
• A: elimination
• C: time to eliminate
, • D/E: absorption
Q4.
A drug bound to plasma proteins is:
A. Pharmacologically active
B. Rapidly excreted
C. Unable to cross membranes
D. Free to act on receptors
E. Rapidly metabolized
Answer: C
Explanation:
• Only free drug = active
Mechanism: Protein binding limits diffusion
Clinical Correlation:
• Hypoalbuminemia → ↑ free drug toxicity
Incorrect:
• A/D: only free drug works
• B/E: binding prolongs duration
Q5.
Which route avoids first-pass metabolism?
A. Oral
B. Rectal (upper)
C. Sublingual
D. Intraperitoneal
E. Enteral
Answer: C
Explanation:
With STUDENT CONSULT Online Access
Authors : Thomas L. Pazdernik & Laszlo Kerecsen
, Rapid Review Pharmacology, 3rd Edition
Chapter 1: Pharmacokinetics.
Q1.
A drug with high lipid solubility and low molecular weight is most likely to:
A. Be poorly absorbed orally
B. Cross cell membranes easily
C. Be rapidly excreted unchanged
D. Have low bioavailability
E. Be restricted to plasma
Answer: B
Explanation:
• Lipid-soluble, small molecules cross membranes via passive diffusion.
Mechanism: Passive diffusion down concentration gradient
Clinical Correlation: CNS drugs must be lipid-soluble to cross BBB
Why others are wrong:
• A: Opposite—lipid solubility ↑ absorption
• C: Lipophilic drugs require metabolism
• D: Bioavailability usually ↑
• E: Hydrophilic drugs stay in plasma
Q2.
First-pass metabolism primarily occurs in the:
A. Kidney
B. Lung
C. Liver
, D. Brain
E. Plasma
Answer: C
Explanation:
• Portal circulation delivers drugs to liver → metabolism before systemic circulation
Mechanism: Hepatic enzyme degradation (CYP450)
Clinical Correlation:
• Oral drugs like propranolol have ↓ bioavailability
Incorrect options:
• A/B/D/E: Not major first-pass sites
Q3.
Which parameter best reflects drug distribution?
A. Clearance
B. Volume of distribution
C. Half-life
D. Bioavailability
E. Absorption rate
Answer: B
Explanation:
• Vd = amount of drug in body / plasma concentration
Mechanism: Indicates tissue vs plasma distribution
Clinical Correlation:
• High Vd → tissue binding (e.g., digoxin)
Incorrect:
• A: elimination
• C: time to eliminate
, • D/E: absorption
Q4.
A drug bound to plasma proteins is:
A. Pharmacologically active
B. Rapidly excreted
C. Unable to cross membranes
D. Free to act on receptors
E. Rapidly metabolized
Answer: C
Explanation:
• Only free drug = active
Mechanism: Protein binding limits diffusion
Clinical Correlation:
• Hypoalbuminemia → ↑ free drug toxicity
Incorrect:
• A/D: only free drug works
• B/E: binding prolongs duration
Q5.
Which route avoids first-pass metabolism?
A. Oral
B. Rectal (upper)
C. Sublingual
D. Intraperitoneal
E. Enteral
Answer: C
Explanation:
