Page 1 of 20
NU 578 UNIT 4 EXAM | FREQUENTLY TESTED
QUESTIONS WITH CORRECT ANSWERS |
BRAND NEW!
Methimazole vs PTU - ✔✔✔ Correct Answer > used in absence of
thyroidectomy.
PTU is not safe in pregnancy. safe in first trimester but then need
to switch to methimazole
both blocks iodine incorporate into thyroid hormones. PTU block
conversion of T3 and T4 in aperiphery.
Methimazole - ✔✔✔ Correct Answer > first line drug for
hyperthyroidism. benefits derive from inhibiting thyroid hormone
synthesis. safer and more convenient than PTU, except when
pregnant or breastfeeding.
MOA:prevents iodine oxidation and prevents iodinated tyrosine
from coupling.
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Methomazole uses/ AE - ✔✔✔ Correct Answer > graves disease,
adjunct to radiation therapy, suppress thyroid hormone synthesis
to prepare for thyroid gland surgery, thyrotoxic crisis. used long
term in absence of surgery.
AE: hypothyroidism, not safe in first trimester of pregnancy.
Radioactive iodine - ✔✔✔ Correct Answer > destroys thyroid with a
single or double PO dose. cannot be used in prengnay patient.
fast, cheap, but produces hypothyroidism. NOT SAFE IN
PREGNANCY!! DO NOT USE IODIDE PRIOR TO RADIOACTIVE
IODINE
propanolol - ✔✔✔ Correct Answer > b antagonist. decreases
sympathetic activation caused by thyroid hormones. good during
thyroid storm and pregnancy
Glucocorticoids - ✔✔✔ Correct Answer > released by adrenal cortex.
cortisol helps cope with stress by increasing BP and BG. GC's
work as anti-inflammatory by decreasing macrophage activity,
decreasing histamine release from mast cells, and staballizing
lysosomal membranes. MUST BE TAPPERED
Steroid SE - ✔✔✔ Correct Answer > SE: Osteoporosis (decreased
calcium absorption and bone demineralization), ulcers from
, Page 3 of 20
increased acid secretion, hyperglycemia, hyperlipidemia, fat
predisposition, growth retardation, adrenal suppression,
decreased wound healing, immunosuppression (increased
infections), hypertension, increased CNS excitation, menstrual
irregularities
Steroid DDI/ Contrainducations - ✔✔✔ Correct Answer > Interactions
related to potassium loss: steroid increase urinary loss of
potassium and can induce hypokalemia.
Digoxin: causes hypokalemia
Diuretics: potassium loss
NSAIDS: increases risk for GI bleeding and ulcers
Insulin and hypoglycemics: steroids cause increased BG
vaccines: can decrease antibody response to vaccines.
Contraindication: systemic fungi infections and those receiving
live virus vaccines
Cyclosporine - ✔✔✔ Correct Answer > an immunosuppressive drug
used to prevent rejection of transplant organs, can reduce
symptoms of RA. can cause kidney damage and other serous
adverse effects. reserved for severe progressive RA that has not
responded to safer drugs.
NU 578 UNIT 4 EXAM | FREQUENTLY TESTED
QUESTIONS WITH CORRECT ANSWERS |
BRAND NEW!
Methimazole vs PTU - ✔✔✔ Correct Answer > used in absence of
thyroidectomy.
PTU is not safe in pregnancy. safe in first trimester but then need
to switch to methimazole
both blocks iodine incorporate into thyroid hormones. PTU block
conversion of T3 and T4 in aperiphery.
Methimazole - ✔✔✔ Correct Answer > first line drug for
hyperthyroidism. benefits derive from inhibiting thyroid hormone
synthesis. safer and more convenient than PTU, except when
pregnant or breastfeeding.
MOA:prevents iodine oxidation and prevents iodinated tyrosine
from coupling.
,Page 2 of 20
Methomazole uses/ AE - ✔✔✔ Correct Answer > graves disease,
adjunct to radiation therapy, suppress thyroid hormone synthesis
to prepare for thyroid gland surgery, thyrotoxic crisis. used long
term in absence of surgery.
AE: hypothyroidism, not safe in first trimester of pregnancy.
Radioactive iodine - ✔✔✔ Correct Answer > destroys thyroid with a
single or double PO dose. cannot be used in prengnay patient.
fast, cheap, but produces hypothyroidism. NOT SAFE IN
PREGNANCY!! DO NOT USE IODIDE PRIOR TO RADIOACTIVE
IODINE
propanolol - ✔✔✔ Correct Answer > b antagonist. decreases
sympathetic activation caused by thyroid hormones. good during
thyroid storm and pregnancy
Glucocorticoids - ✔✔✔ Correct Answer > released by adrenal cortex.
cortisol helps cope with stress by increasing BP and BG. GC's
work as anti-inflammatory by decreasing macrophage activity,
decreasing histamine release from mast cells, and staballizing
lysosomal membranes. MUST BE TAPPERED
Steroid SE - ✔✔✔ Correct Answer > SE: Osteoporosis (decreased
calcium absorption and bone demineralization), ulcers from
, Page 3 of 20
increased acid secretion, hyperglycemia, hyperlipidemia, fat
predisposition, growth retardation, adrenal suppression,
decreased wound healing, immunosuppression (increased
infections), hypertension, increased CNS excitation, menstrual
irregularities
Steroid DDI/ Contrainducations - ✔✔✔ Correct Answer > Interactions
related to potassium loss: steroid increase urinary loss of
potassium and can induce hypokalemia.
Digoxin: causes hypokalemia
Diuretics: potassium loss
NSAIDS: increases risk for GI bleeding and ulcers
Insulin and hypoglycemics: steroids cause increased BG
vaccines: can decrease antibody response to vaccines.
Contraindication: systemic fungi infections and those receiving
live virus vaccines
Cyclosporine - ✔✔✔ Correct Answer > an immunosuppressive drug
used to prevent rejection of transplant organs, can reduce
symptoms of RA. can cause kidney damage and other serous
adverse effects. reserved for severe progressive RA that has not
responded to safer drugs.
