NURS 615 – Exam 3 Study Guide | Study Questions
and verified Answers with Rationales | A+ Graded |
2026 Updates | 100% correct
WEEK 8 – PAIN MANAGEMENT
1. First-Line Treatment for Acute Pain
Q: What is first line for acute mild musculoskeletal pain? ✅
Answer: NSAIDs (ibuprofen, naproxen) ± acetaminophen
💡 Rationale:
Guidelines recommend non-opioids FIRST. NSAIDs ↓ inflammation (main cause of
musculoskeletal pain).
2. NSAIDs BLACK BOX WARNING
Q: Why do NSAIDs have a black box warning? ✅
Answer:
↑ Risk of CV events (MI, stroke) ↑
Risk of GI bleeding, ulcer, perforation
💡 Rationale:
COX-1 inhibition ↓ gastric protection; COX-2 imbalance → ↑ clot risk.
, 3. Salicylate Toxicity
Q: First sign of aspirin toxicity? ✅
Answer: Tinnitus
💡 Rationale:
Early CNS effect → ringing ears before metabolic changes.
4. Acetaminophen Toxicity
Q: Signs of liver failure?
✅ Answer:
• RUQ pain
• Jaundice
• Dark urine
• N/V
💡 Rationale:
Toxic metabolite (NAPQI) damages liver.
5. Opioid Receptors
Q: Difference between agonist vs partial vs antagonist?
Type Example Key Concept
Full agonist Morphine Full effect (high efficacy)
Partial agonist Buprenorphine Ceiling effect
Antagonist Naloxone Reversal
💡 Rationale:
• Affinity = binding
• Efficacy = activation
and verified Answers with Rationales | A+ Graded |
2026 Updates | 100% correct
WEEK 8 – PAIN MANAGEMENT
1. First-Line Treatment for Acute Pain
Q: What is first line for acute mild musculoskeletal pain? ✅
Answer: NSAIDs (ibuprofen, naproxen) ± acetaminophen
💡 Rationale:
Guidelines recommend non-opioids FIRST. NSAIDs ↓ inflammation (main cause of
musculoskeletal pain).
2. NSAIDs BLACK BOX WARNING
Q: Why do NSAIDs have a black box warning? ✅
Answer:
↑ Risk of CV events (MI, stroke) ↑
Risk of GI bleeding, ulcer, perforation
💡 Rationale:
COX-1 inhibition ↓ gastric protection; COX-2 imbalance → ↑ clot risk.
, 3. Salicylate Toxicity
Q: First sign of aspirin toxicity? ✅
Answer: Tinnitus
💡 Rationale:
Early CNS effect → ringing ears before metabolic changes.
4. Acetaminophen Toxicity
Q: Signs of liver failure?
✅ Answer:
• RUQ pain
• Jaundice
• Dark urine
• N/V
💡 Rationale:
Toxic metabolite (NAPQI) damages liver.
5. Opioid Receptors
Q: Difference between agonist vs partial vs antagonist?
Type Example Key Concept
Full agonist Morphine Full effect (high efficacy)
Partial agonist Buprenorphine Ceiling effect
Antagonist Naloxone Reversal
💡 Rationale:
• Affinity = binding
• Efficacy = activation
