WGU UNIVERSITY OF HEALTH AND MEDICAL
SCIENCES| SCHOOL OF PHARMACY AND NURSING
SCIENCES| DEPARTMENT OF PHARMACOLOGY
AND THERAPEUTICS
UNDERGRADUATE PRACTICE EXAMINATION
2025/2026 ACADEMIC YEAR – SEMESTER II
Pharmacology
Drug Delivery Systems & Dosage Forms
what is the greatest disadvantage of using microparticles in drug delivery
a. parenteral route which causes pain
b. uncontrolled release
c. low toxicity
d. no distribution throughout the body
a. parenteral route which causes pain
microparticle size and shape can be determined by all but one technique
a. conventional light microscopy
b. scanning electron microscopy
c. pycnometer
d. confocal fluorescence microscopy
c. pycnometer
1|Page
,what does ADME stand for
a. absorption, distribution, metabolism, excretion
b. absorption, dosage, medicine, effect
c. adsorption, dosage, medicine excretion
d. adsorption, distribution, metabolism, and effect
a. absorption, distribution, metabolism, excretion
what are the characteristics of Class I drugs
a. High permeability, High solubility.
b. High Permeability, Low Solubility
c. Low Permeability, High Solubility
d. Low Permeability, Low Solubility
a. high permeability, high solubility
which of these mechanisms is not used for drug absorption
a. Pore transport
b. Exocytosis
c. Active transport
d. Passive diffusion
b. exocytosis
what component of a polymeric prodrug functions to control the release of the drug?
a. Targeting moiety
2|Page
,b. Solubilizing group
c. Spacer
d. Polymeric back bone
c. the spacer
what is NOT an advantage of injection route?
a. High bioavailability
b. High patient compliance
c. Reproducible
d. Immediate effects
b. high patient compliance
What is the principal organ involved in first-pass metabolism?
a. Small intestine
b. Kidney
c. Liver
d. A and C
d. Liver
what is the choice polymer for a prodrug?
a. PEI
b. DIVEMA
c. PEG
3|Page
, d. SMA
c. PEG
All of the following are correct about the dialysis method of preparation of micelles except:
a. It is suitable for hydrophobic polymers.
b. Organic solvents are used in this method.
c. Addition of water freezes the micelle.
d. Process of preparation is very fast.
d. Process of preparation is very fast
Which of the following is NOT a carbohydrate based natural polymer for microencapsulation?
a. Starch agarose
b. Alginate
c. Gelatin
d. Cellulose
c. Gelatin
Which is TRUE of physiologic PK models?
a. Models are based on known physiologic and mammillary data.
b. Data fitting is not required.
c. Blood flow is responsible for only distributing drug to one part of the body.
d. Models and data can be applied directly to both animal species and humans.
b. Data fitting is not required
4|Page
SCIENCES| SCHOOL OF PHARMACY AND NURSING
SCIENCES| DEPARTMENT OF PHARMACOLOGY
AND THERAPEUTICS
UNDERGRADUATE PRACTICE EXAMINATION
2025/2026 ACADEMIC YEAR – SEMESTER II
Pharmacology
Drug Delivery Systems & Dosage Forms
what is the greatest disadvantage of using microparticles in drug delivery
a. parenteral route which causes pain
b. uncontrolled release
c. low toxicity
d. no distribution throughout the body
a. parenteral route which causes pain
microparticle size and shape can be determined by all but one technique
a. conventional light microscopy
b. scanning electron microscopy
c. pycnometer
d. confocal fluorescence microscopy
c. pycnometer
1|Page
,what does ADME stand for
a. absorption, distribution, metabolism, excretion
b. absorption, dosage, medicine, effect
c. adsorption, dosage, medicine excretion
d. adsorption, distribution, metabolism, and effect
a. absorption, distribution, metabolism, excretion
what are the characteristics of Class I drugs
a. High permeability, High solubility.
b. High Permeability, Low Solubility
c. Low Permeability, High Solubility
d. Low Permeability, Low Solubility
a. high permeability, high solubility
which of these mechanisms is not used for drug absorption
a. Pore transport
b. Exocytosis
c. Active transport
d. Passive diffusion
b. exocytosis
what component of a polymeric prodrug functions to control the release of the drug?
a. Targeting moiety
2|Page
,b. Solubilizing group
c. Spacer
d. Polymeric back bone
c. the spacer
what is NOT an advantage of injection route?
a. High bioavailability
b. High patient compliance
c. Reproducible
d. Immediate effects
b. high patient compliance
What is the principal organ involved in first-pass metabolism?
a. Small intestine
b. Kidney
c. Liver
d. A and C
d. Liver
what is the choice polymer for a prodrug?
a. PEI
b. DIVEMA
c. PEG
3|Page
, d. SMA
c. PEG
All of the following are correct about the dialysis method of preparation of micelles except:
a. It is suitable for hydrophobic polymers.
b. Organic solvents are used in this method.
c. Addition of water freezes the micelle.
d. Process of preparation is very fast.
d. Process of preparation is very fast
Which of the following is NOT a carbohydrate based natural polymer for microencapsulation?
a. Starch agarose
b. Alginate
c. Gelatin
d. Cellulose
c. Gelatin
Which is TRUE of physiologic PK models?
a. Models are based on known physiologic and mammillary data.
b. Data fitting is not required.
c. Blood flow is responsible for only distributing drug to one part of the body.
d. Models and data can be applied directly to both animal species and humans.
b. Data fitting is not required
4|Page
