NR 293 Pharmacology Week 10 ATI-Based Study Guide 2026
|Chamberlain College
1. A nurse is preparing to administer gentamicin to a client. Which of the
following laboratory values should the nurse monitor to identify a potential
adverse effect of this medication?
A. Serum glucose
B. Serum creatinine
C. Serum potassium
D. Prothrombin time
Answer: B
Rationale: Gentamicin is an aminoglycoside which is known to be nephrotoxic. Monitoring
serum creatinine and BUN is essential to detect renal impairment.
2. A client is prescribed rifampin for the treatment of tuberculosis. Which of the
following side effects should the nurse inform the client to expect?
A. Peripheral neuropathy
B. Orange-colored urine and sweat
C. Constipation
D. Tinnitus
Answer: B
Rationale: Rifampin commonly causes a harmless reddish-orange discoloration of urine,
sweat, saliva, and tears.
,3. Which of the following medications is used to treat a client who has a
systemic fungal infection?
A. Metronidazole
B. Amphotericin B
C. Acyclovir
D. Linezolid
Answer: B
Rationale: Amphotericin B is a potent antifungal medication used for serious systemic
fungal infections.
4. A nurse is teaching a client about a new prescription for tetracycline. Which
of the following instructions should the nurse include?
A. Take the medication with a glass of milk.
B. Wear sunscreen and protective clothing when outdoors.
C. Expect the urine to turn dark brown.
D. Decrease fluid intake while taking this drug.
Answer: B
Rationale: Tetracyclines cause photosensitivity, making the skin more susceptible to
sunburn. They should not be taken with milk as calcium binds the drug.
5. A client receiving vancomycin IV reports flushing, hypotension, and a rash on
the upper body. What is the nurse’s priority action?
A. Administer epinephrine subcutaneously.
B. Stop the infusion immediately.
C. Slow the infusion rate.
D. Document the findings as a normal reaction.
Answer: C
, Rationale: These symptoms characterize ‘Red Man Syndrome,’ which is usually caused by
rapid infusion. The nurse should slow the rate rather than stop it entirely unless it is a true
anaphylactic reaction.
6. A nurse is caring for a client with a history of severe penicillin allergy. Which
class of antibiotics should the nurse clarify with the provider before
administering due to potential cross-sensitivity?
A. Sulfonamides
B. Fluoroquinolones
C. Cephalosporins
D. Macrolides
Answer: C
Rationale: There is a known cross-sensitivity between penicillins and cephalosporins due
to their similar beta-lactam ring structure.
7. Which of the following is a common adverse effect of zidovudine (AZT) used
in HIV treatment?
A. Hyperglycemia
B. Bone marrow suppression
C. Cardiac arrhythmias
D. Hypotension
Answer: B
Rationale: Zidovudine can cause severe anemia and neutropenia due to bone marrow
suppression.
|Chamberlain College
1. A nurse is preparing to administer gentamicin to a client. Which of the
following laboratory values should the nurse monitor to identify a potential
adverse effect of this medication?
A. Serum glucose
B. Serum creatinine
C. Serum potassium
D. Prothrombin time
Answer: B
Rationale: Gentamicin is an aminoglycoside which is known to be nephrotoxic. Monitoring
serum creatinine and BUN is essential to detect renal impairment.
2. A client is prescribed rifampin for the treatment of tuberculosis. Which of the
following side effects should the nurse inform the client to expect?
A. Peripheral neuropathy
B. Orange-colored urine and sweat
C. Constipation
D. Tinnitus
Answer: B
Rationale: Rifampin commonly causes a harmless reddish-orange discoloration of urine,
sweat, saliva, and tears.
,3. Which of the following medications is used to treat a client who has a
systemic fungal infection?
A. Metronidazole
B. Amphotericin B
C. Acyclovir
D. Linezolid
Answer: B
Rationale: Amphotericin B is a potent antifungal medication used for serious systemic
fungal infections.
4. A nurse is teaching a client about a new prescription for tetracycline. Which
of the following instructions should the nurse include?
A. Take the medication with a glass of milk.
B. Wear sunscreen and protective clothing when outdoors.
C. Expect the urine to turn dark brown.
D. Decrease fluid intake while taking this drug.
Answer: B
Rationale: Tetracyclines cause photosensitivity, making the skin more susceptible to
sunburn. They should not be taken with milk as calcium binds the drug.
5. A client receiving vancomycin IV reports flushing, hypotension, and a rash on
the upper body. What is the nurse’s priority action?
A. Administer epinephrine subcutaneously.
B. Stop the infusion immediately.
C. Slow the infusion rate.
D. Document the findings as a normal reaction.
Answer: C
, Rationale: These symptoms characterize ‘Red Man Syndrome,’ which is usually caused by
rapid infusion. The nurse should slow the rate rather than stop it entirely unless it is a true
anaphylactic reaction.
6. A nurse is caring for a client with a history of severe penicillin allergy. Which
class of antibiotics should the nurse clarify with the provider before
administering due to potential cross-sensitivity?
A. Sulfonamides
B. Fluoroquinolones
C. Cephalosporins
D. Macrolides
Answer: C
Rationale: There is a known cross-sensitivity between penicillins and cephalosporins due
to their similar beta-lactam ring structure.
7. Which of the following is a common adverse effect of zidovudine (AZT) used
in HIV treatment?
A. Hyperglycemia
B. Bone marrow suppression
C. Cardiac arrhythmias
D. Hypotension
Answer: B
Rationale: Zidovudine can cause severe anemia and neutropenia due to bone marrow
suppression.
