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In 1992, there were 980 deaths in a Midwestern city with a population of
1,000,000. At the beginning of that year, 900 cases of AIDS existed in this
population. During the year, 250 new cases of AIDS were diagnosed,
and 75 people died of the disease in 1992.
Using the data given above, what was the incidence rate (per 100,000
population) at the end of 1992 for AIDS?
a. 6
b. 25
c. 88
d. 116
ANSWERS: B
What level of prevention is a blood pressure screening program for high
school students who are pregnant?
a. primary
b. secondary
c. tertiary
ANSWERS: B
,Mr. Forbes complains of "indigestion" and becomes sweaty and pale. His
wife takes him to the Emergency Department at Northwestern Memorial
Hospital. A cardiac catheterization 2 days later shows partial blockage
of his right coronary artery (RCA).
Blockage of the right coronary artery can lead to myocardial cell injury
because it results in which of the following?
a. bilirubin accumulation in myocardial cells
b. alteration in the genetic material of myocardial cells
c. reduced energy production in myocardial cells
d. activation of the complement system
ANSWERS: C
When myocardial cells are injured, the function of the Na-K membrane
pump may be impaired. Which of the following may then result?
a. intracellular sodium will increase
b. extracellular potassium will decrease
c. cell volume will decrease
d. all of the above
ANSWERS: A
,Mr. Forbes is being prepared for open heart surgery when he suffers a
myocardial infarction in which a large part of his left ventricle has suffered
lethal cell injury.
Mr. Forbes' CPK-MB and LDH1, enzymes associated with myocardial cells, are
significantly elevated. What is the best explanation for this?
a. It is a sign that necrotic myocardial cells have released their cytoplasmic
contents into the blood.
b. It is a sign of reversible fatty accumulation in the myocardial cells
c. It is a sign that the myocardial cells are undergoing hypertrophy.
d. None of the above.
ANSWERS: A
If a tissue specimen of myocardial cells were obtained for examination
from Mr. Forbes, which of the following findings would indicate
irreversible cell injury?
a. cellular swelling
b. decreased ATP production
c. decreased intracellular calcium
d. dissolution of nuclear material
ANSWERS: D
The accumulation of lactic acid that occurs with impaired energy production
results from which of the following?
a. increased intracellular glucose
b. increased anaerobic metabolism
c. decreased metabolic rate
d. increased oxidative phosphorylation
ANSWERS: B
, A mountain climber is stranded at 23,000 feet in the Swiss Alps and has lost
all his equipment and supplies in an avalanche. Subsequently, he suffers cell
injury due to impaired ATP production. The reason for the decrease in ATP
is which of the following?
a. enzyme inhibition
b. uncoupling
c. hypoxia
d. none of the above
ANSWERS: C
An elderly patient develops an obstruction in his left middle cerebral
artery. The brain tissue supplied by this artery becomes hypoxic. The best
explanation for this is which of the following?
a. the obstruction results in decreased blood flow
b. the obstruction results in decreased hemoglobin in the blood
c. while blood flow stays the same, the obstruction reduces oxygen
content in the blood
d. none of the above explain the reason for the hypoxia
ANSWERS: A
Increased mobilization and delivery of free fatty acids to liver cells can
result in fat accumulation. Which of the following problems results in
increased mobilization of free fatty acids?
a. anemia
b. hepatic toxins
c. starvation
d. hypoxia
ANSWERS: C