NSC 830 Adv Pharm Questions and
Answers with Complete Solution 2026
Update | 100% Correct | EKU
Distribution - ANSWERS Drug movement from the blood to tissues and cells
What is Distribution Affected by? - ANSWERS Protein binding, blood flow to
the tissues, ability of the drug to exit the vascular space, and the ability of the
drug to enter the cell
What do most drugs bind with - ANSWERS plasma protein - albumin
What does plasma protein albumin do after binding w drugs - ANSWERS acts
as a carrier
Bound drug molecules are considered - ANSWERS inactive
Unbound/Free drug molecules are considered - ANSWERS active
What portion of the drug acts on body cells - ANSWERS the free or unbound
portion
If a drug molecules is bound to plasma protein, why is it considered inactive? -
ANSWERS It is too big to cross over into the tissues from the plasma
, In order for drugs to cross the Blood Brain Barrier they must be: - ANSWERS
Un-ionized, small molecules, and lipid soluable
in order for drugs to pass the placental barrier they must be: - ANSWERS Lipid
soluable, smaller molecule drugs, and there must be passive diffusion
Metabolism - ANSWERS the process of chemically changing a drug to a
different compound called a metabolite
What are active drugs changed into in order to be excreted? - ANSWERS one
or more inactive metabolites
A function of Metabolism: - ANSWERS Changing from an active metabolite to
an inactive metabolite OR changing from an inactive metabolite to an active
metabolite.
If a drug is administered as an inactive pro-drug what must happen for the drug to
have an effect? - ANSWERS The drug must be metabolized to an active
metabolite from the inactive pro-drug state to have an effect
What must happen to drugs in order to be excreted by the kidneys? -
ANSWERS they must be converted from lipid soluble to water soluble
metabolites
What is the main site of drug metabolism? - ANSWERS The liver
Answers with Complete Solution 2026
Update | 100% Correct | EKU
Distribution - ANSWERS Drug movement from the blood to tissues and cells
What is Distribution Affected by? - ANSWERS Protein binding, blood flow to
the tissues, ability of the drug to exit the vascular space, and the ability of the
drug to enter the cell
What do most drugs bind with - ANSWERS plasma protein - albumin
What does plasma protein albumin do after binding w drugs - ANSWERS acts
as a carrier
Bound drug molecules are considered - ANSWERS inactive
Unbound/Free drug molecules are considered - ANSWERS active
What portion of the drug acts on body cells - ANSWERS the free or unbound
portion
If a drug molecules is bound to plasma protein, why is it considered inactive? -
ANSWERS It is too big to cross over into the tissues from the plasma
, In order for drugs to cross the Blood Brain Barrier they must be: - ANSWERS
Un-ionized, small molecules, and lipid soluable
in order for drugs to pass the placental barrier they must be: - ANSWERS Lipid
soluable, smaller molecule drugs, and there must be passive diffusion
Metabolism - ANSWERS the process of chemically changing a drug to a
different compound called a metabolite
What are active drugs changed into in order to be excreted? - ANSWERS one
or more inactive metabolites
A function of Metabolism: - ANSWERS Changing from an active metabolite to
an inactive metabolite OR changing from an inactive metabolite to an active
metabolite.
If a drug is administered as an inactive pro-drug what must happen for the drug to
have an effect? - ANSWERS The drug must be metabolized to an active
metabolite from the inactive pro-drug state to have an effect
What must happen to drugs in order to be excreted by the kidneys? -
ANSWERS they must be converted from lipid soluble to water soluble
metabolites
What is the main site of drug metabolism? - ANSWERS The liver
