LEHNES PHARMACOTHERAPEUTICS
ADVANCED PRACTICE NURSES PHYSICIAN
ASSISTANTS THIRD EDITION TEST BANK
REVIEW CHAPTERS ONE TO LAST 2026
QUESTIONS ANSWERS GRADED A+
⩥Pharmacokinetics- (Tics--> TIME).
Answer: The movement of the drug in the body over time through
absorption, distribution, metabolism, and excretion
⩥Pharmodynamics.
Answer: What the drug does to the body--> biological response
⩥Absorption via.
Answer: Cell membranes (lipid-based)
1. Channels & Pores (small molecules)
2. Transport system (selective)
3. DIRECT PENETRATION (LIPID SOLUBLE)
⩥PGP (p-glycoprotein).
Answer: Multi-drug transport protein (transport system) that moves
drugs OUT of cells
, ⩥What meds can NOT penetrate cell membranes.
Answer: 1. Polar molecules- water-soluble drugs
2. Ions- except for the VERY small (like dissolves like)
3. Ion trapping/pH partitioning (drug accumulates on a side that
encourages ionization (undissolved)
⩥What impacts the rate of absorption.
Answer: 1. Rate of dissolution (immediate release, enteric coating, etc.)
2. Surface area (blood flow, lipid solubility, & pH partitioning)
⩥Bioavailability.
Answer: 1. A measure of the extent of drug absorption for a given drug
and route (from 0% to 100%).
2. Drugs are equal in bioavailability if they absorb at the same rate and
to same extent
3. Absorption/bioavailability impacted by ROUTE
⩥Three factors determining Distribution of a drug.
Answer: 1. Blood flow (or lack thereof) to tissues (abscess/solid tumors)
2. Ability for the drug to exit vascular system (BBB/Placental)
3. Protein binding- bound/unbound; affinity, binding site competition
4. Ability of drug to enter cells- lipd-solubility or transport system
ADVANCED PRACTICE NURSES PHYSICIAN
ASSISTANTS THIRD EDITION TEST BANK
REVIEW CHAPTERS ONE TO LAST 2026
QUESTIONS ANSWERS GRADED A+
⩥Pharmacokinetics- (Tics--> TIME).
Answer: The movement of the drug in the body over time through
absorption, distribution, metabolism, and excretion
⩥Pharmodynamics.
Answer: What the drug does to the body--> biological response
⩥Absorption via.
Answer: Cell membranes (lipid-based)
1. Channels & Pores (small molecules)
2. Transport system (selective)
3. DIRECT PENETRATION (LIPID SOLUBLE)
⩥PGP (p-glycoprotein).
Answer: Multi-drug transport protein (transport system) that moves
drugs OUT of cells
, ⩥What meds can NOT penetrate cell membranes.
Answer: 1. Polar molecules- water-soluble drugs
2. Ions- except for the VERY small (like dissolves like)
3. Ion trapping/pH partitioning (drug accumulates on a side that
encourages ionization (undissolved)
⩥What impacts the rate of absorption.
Answer: 1. Rate of dissolution (immediate release, enteric coating, etc.)
2. Surface area (blood flow, lipid solubility, & pH partitioning)
⩥Bioavailability.
Answer: 1. A measure of the extent of drug absorption for a given drug
and route (from 0% to 100%).
2. Drugs are equal in bioavailability if they absorb at the same rate and
to same extent
3. Absorption/bioavailability impacted by ROUTE
⩥Three factors determining Distribution of a drug.
Answer: 1. Blood flow (or lack thereof) to tissues (abscess/solid tumors)
2. Ability for the drug to exit vascular system (BBB/Placental)
3. Protein binding- bound/unbound; affinity, binding site competition
4. Ability of drug to enter cells- lipd-solubility or transport system
