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Example of Muscarinic Agonist (3) - Answers Bethanechol
Cevimelin
Pilocarpine
main therapeutic use of muscarinic agonist? - Answers Urinary retention
off label use of muscarinic agonist - Answers GERD
CV adverse effect of muscarinic agonist - Answers hypotension and bradycardia
which medication class has an adverse effect of excessive salivation - Answers increase secretion of
gastric acid, abd cramps, diarrhea, Muscarinic agonist
muscarinic agonist is CI with which patients - Answers that may cause ruptured bladder, patients with
UTI or weak bladder wall
why does muscarinic agonist CI in pt w/ latent or active asthma - Answers bronchoconstriction
Muscrarinic agonist are CI in pts with hyperthyroidism d/t what? - Answers opposite effect due to
reflex
Urinary adverse effects of muscarinic agonist - Answers increased bladder pressure --> ruptured
bladder
how do you minimize adverse effects of muscarinic agonist? - Answers take on empty stomach
what meds reduce adverse effects of muscarinic agonist - Answers atropine
toxicology mnemonic for muscarinic agonist (10) - Answers DUMBELS (diaphoresis/diarrhea urination
miosis bradycardia/bronchospams/bronchorrhea, emesis, lacrimation, salivation)
muscarinic agonist that treats xerostomia and manages keratoconjuctivitis sicca - Answers cevimeline
muscarinic agonist that is mainly used for topical therapy of glaucoma - Answers pilocarpine
examples of muscarinic antagonist (4) - Answers atropinescopolamineipratropium
bromidedicyclomine
therapeutic goal for muscarinic antagonist - Answers treatment of bradycardia/AV blockantidote to
anticholinesterase poisoningpreanesthetic medication
High risk patients for muscarinic antagonist (4) - Answers nonbradycardic dysrthmias
(tachydysrhythmias) and MIrisk for glaucomarisk for myasthenia crisis in pts with myasthenia
gravisurinary retention in BPH
how to minimize adverse effects of muscarinic antagonsit (5) - Answers dry mouth - fluids/ saliva
stimulants/ moisturizersphotophobia - sunglassesurinary retention - cath or bethanecholconstipation
- fluids and fibertachycardia - monitor
scopolamine is like atropine - Answers but with 2 exceptions:, sedation, and suppresses emesis and
motion sickness
Ipratropium bromide is used in which respiratory dx (3) - Answers asthma, copd, rhinits
Dicyclomine is indicated for what? (3) - Answers IBSDiarrheaHyper-motility
mydriatic cycloplegics are for what kind of procedures - Answers ophthalmic
which 2 centrally acting anticholinergics are used to treat parkinson disease and drug-induced
parkinsonism - Answers benztropine and trihexyphenidyl
effects of toxic doses of muscarinic antagonist (5) - Answers hallucinations, delirium, coma, resp
arrest, death
pharm effects on the heart with muscarinic antagonist - Answers increase HR
pharm effects on exocrine glands with muscarinic antagonist - Answers decrease secreation from
salivary/bronchial/sweat glands and acid-secreting cells of the stomach
pharm effects on smooth muscle with muscarinic antagonist - Answers relaxation of bronchi,
decreased tone of urinary bladder detrusor, decreased tone and motility of GI tract
pharm effects on eyes with muscarinic antagonist - Answers mydriasis (dilation) and focus of far
vision
pharm effects on CNS with muscarinic antagonist - Answers MILD CNS excitation
examples of cholinesterase inhibitors (4) - Answers pryidostigmine
neostigminephysostigmineedrophonium
cholinesterase inhibitors leaves what neurotransmitter available for use - Answers ACh (actylcholine)
neuromuscular effects of cholinesterase inhibitors - Answers increase force of contraction
toxic dose of muscarinic inhibitors causes which neuromuscular effects - Answers decrease force of
contraction d/t neuromuscular blockade