COMPLETE QUESTIONS AND CORRECT
ANSWERS
◉ Leukotrienes Answer: -Inflammatory mediator
-Stimulates contraction of smooth muscles in bronchioles
-Overproduction causes inflammation in asthma and allergic rhinitis
◉ H2 Receptors Answer: -Antiinflammatory
-Suppresses leukocyte function
-Decreased histamine
-Increased gastric acid production
-Smooth muscle relaxation
◉ Prostaglandins Answer: A group of lipids made at the site of tissue
injury. They control inflammation, blood clot formation, and blood flow.
-Stimulate nerve endings= Pain
◉ Allergy: Type I IgE-Mediated Response Answer: -Immediate
-IgE
-Principal cells : Mast cells
-Ex: Seasonal allergic rhinitis, Hay fever
,◉ Mitochondria Answer: Powerhouse of the cell, organelle that is the
site of ATP (energy) production
◉ Endoplasmic Reticulum Answer: A cell structure that forms a maze of
passageways in which proteins and other materials are carried from one
part of the cell to another.
◉ Peroxisome and Lysosome Answer: -Digestive enzymes
-Break down waste and foreign material
◉ Allergy: Type II Tissue-Specific Response Answer: -Immediate
-IgG, IgM
-Principal Cells: Macrophages in tissues
-drug allergies/allergies against infectious agents
-the antibody binds to the antigen on the cell surface
- Ex: Graves disease, Autoimmune thrombocytopenic purpura, ABO
incompatability
1) The cell to be destroyed by the antibody
2) Cell destruction through phagocytosis by macrophages
3) Damage to the cell by neutrophils triggering phagocytosis
4) Natural killer cells to release toxic substances that destroy the target
cell
5) Malfunction of the cell without destruction
, ◉ Allergy: Type III Immune Complex-Mediated Response Answer: -
Immediate
-IgG, IgM
-Principal cells: Neutrophils
-The antibody binds to the antigen in the blood or body fluids and then
circulates to the tissue
-Not organ specific
-Ex: Systemic lupus erythematosus
◉ Allergy: Type IV Cell-Mediated Response Answer: -Delayed
-Hypersensitivity reactions
-Principal cells: lymphocytes/macrophages
-Mediated by T-lymphocytes
-Does not use antibodies
-Localized contact dermatitis (Poison Ivy)
◉ Innate immunity Answer: -Physical, mechanical, biochemical
-Nonspecific
-Ex: intact skin, GI movement, Eyelashes sweeping debris, mucous,
tears, bile, normal flora on skin, mouth, vagina, etc.
-Inflammatory response (immediate)
- Lymphocyte production (slow-acting, specific protection)