COMPLETE QUESTIONS AND ANSWERS
◉ How do you manage COPD exacerbation?
Answer: SABA
Systemic glucocorticoids
Antibiotics: esp. for smokers
Supplemental O2 for keep sat 88-92%
◉ menstrual cycle phases
Answer: Follicular Phase: first half of cycle (day 1-14)
Luteal Phase: second half of cycle
Full cycle takes 28 days
◉ estrogen and sex characteristics
Answer: Reproductive tract & secondary sex charac.
Estrogens influence:
-Ductal growth in breast
-Thickening & cornification of vaginal epithelium
,-Proliferation of uterine epithelium
-Copious secretion of thickened mucus from endocervical glands
◉ Estrogen metabolic actions
Answer: Positive effect on bone mass-blocks bone resorption
Favorable effects on cholesterol levels
Blood coagulation
Glucose homeostasis: promote glucose uptake
◉ Estrogen AE
Answer: Endometrial hyperplasia & carcinoma
Promotes existing breast cxr
Ovarian cxr
CV events
Nausea
Increase risk of blood clots
others: Gallbladder dx, jaundice, HA, chloasma
◉ Menopause female w/uterus
Answer: Needs estrogen AND progesterone
(estrogen can thicken lining of uterus> hyperplasia> high risk of
endometrial cxr)
,◉ Menopause female w/out uterus
Answer: Needs estrogen only
◉ Estrogen and menopause
Answer: If started early> pt gets bone & cardiac benefits w/out
cardiac risks
◉ Optimal time for hormone replacement
Answer: About 5 years
Give lowest dose to control vasomotor symptoms
Don't start w/hormone if pt on menopause over 5 yrs> at risk for
clots
◉ Estrogen therapeutic uses
Answer: Menopausal hormone
Female hypogonadism
Acne
◉ Estrogens are major substrates of
Answer: CYP1A2 and CYP3A4
Interacts w/ antiseizure, warfarin, etc.
, ◉ Selective Estrogen Receptor Modulators (SERMs)
Answer: Tamoxifen
Toremifene
Raloxifene
*Benefits of estrogen while avoiding drawbacks
◉ Duavee (conjugated estrogens/bazedoxifene) treats
Answer: vasomotor symptoms
osteoporosis in postmenopausal women
good for preventing breast cxr
◉ Progestins: Therapeutic Uses
Answer: postmenopausal hormone therapy
amenorrhea
infertility
prematurity prevention
endometrial carcinoma and hyperplasia
◉ SSRI's can help with
Answer: vasomotor symptoms of menopause