Page 1 of 177
HESI PHARMACOLOGY EXAM PRACTICE 2026 (NCLEX PN)
2 VERSIONS ACTUAL QUESTIONS EXAM 2026-2027 ALL
QUESTIONS WITH ANSWERS EXAM 2026 LATEST EDITION
SOLVED QUESTIONS & ANSWERS VERIFIED
A client receives a new prescription for ciprofloxacin (Cipro), a synthetic
quinolone. When teaching about this drug, which information in the client's
history requires special emphasis by the nurse?
Snacks on dairy products such as yogurt or ice cream.
Previously had a mild allergic reaction to a cephalosporin.
Consumes alcoholic drinks occasionally on the weekends.
Works twenty hours a week as a lifeguard at the local pool.
Works twenty hours a week as a lifeguard at the local pool.
A client who is receiving chemotherapy is prescribed ondansetron (Zofran).
What side effect should the nurse include in the teaching plan?
Headache.
Dry mouth.
Impaired taste.
Blurred vision.
Headache.
Which heparin concentration should the nurse use to convert an intravenous
site to a heparin lock?
10 units/ml.
100 units/ml.
, Page 2 of 177
1000 units/ml.
10,000 units/ml.
100 units/ml.
Which findings should the nurse identify in an adult client with possible
chronic salicylate intoxication?
Tinnitus and hearing loss.
Photosensitivity and nervousness.
Acute gastrointestinal bleeding and anorexia.
Hyperventilation and central nervous system effects.
Tinnitus and hearing loss.
A client is admitted for atrial fibrillation, and the healthcare provider prescribes
disopyramide (Norpace). After explaining the action of this antidysrhythmic
agent, which complaint should the nurse instruct the client to report?
Joint pain.
Dizziness or muscle weakness.
Daily weight gain of 2 pounds.
Dry mouth.
Daily weight gain of 2 pounds.
An emergency department triage nurse is interviewing a female client who has
a history of epilepsy with tonic-clonic seizures controlled by phenytoin
(Dilantin). Which information is most significant in planning this client's care?
She has missed 2 menstrual periods.
She has had no dental care for several years.
She ran out of her medication 4 days ago.
She has smoked 3 packs of cigarettes a day for 10 years.
She ran out of her medication 4 days ago.
The healthcare provider prescribes pyridostigmine bromide (Mestinon) tablets
for a client with myasthenia gravis (MG). What instruction should the nurse
provide this client?
Increase activity in the afternoon when the medication is most effective.
, Page 3 of 177
Take the medication 30 to 45 minutes before eating.
Use a PRN dose for increasing muscular weakness or fasciculations.
Give the client a dietary guide that describes low-protein foods.
Take the medication 30 to 45 minutes before eating.
What action should the nurse implement to provide analgesic titration for a
client in pain ?
Teach the client to increase the time range between doses of pain medication.
Monitor the effects of continuous intravenous infusion of narcotic analgesics.
Plan with the client how to use a specific total dose of analgesic over a 24-
hour period.
Determine the optimal analgesic dosage required that causes the least side
effects.
Determine the optimal analgesic dosage required that causes the least side effects.
Which common side effect should the nurse alert a female client about when
medroxyprogesterone (Depo-Provera) is prescribed?
Leg or calf pain.
Headaches or visual changes.
Vaginal bleeding after discontinuing the medication.
Jaundice during the first 3 weeks of administration.
Vaginal bleeding after discontinuing the medication.
Miotic drug therapy for the treatment of glaucoma is based chiefly upon which
physiologic action?
Enhancing aqueous humor outflow.
Inhibiting aqueous humor production.
Maintaining intraocular pressure.
Preventing extraocular infection.
Enhancing aqueous humor outflow.
A client receives a new prescription for nitroglycerin (Nitrostat) tablets. Which
instruction should the nurse include in this client's teaching?
Take the medication at least an hour before every meal.
, Page 4 of 177
Monitor your pulse for 60 seconds before administration.
Place under the tongue as needed every 5 minutes up to 3 times.
Resume normal activities after chest pain relief is obtained.
Place under the tongue as needed every 5 minutes up to 3 times.
The nurse administers the initial dose of a fentanyl (Duragesic) transdermal
patch to a client with chronic pain. When monitoring the client an hour later,
which assessment is most important for the nurse to obtain?
Level of consciousness.
Moistness of mucosa.
Bowel sound activity.
Numeric pain scale.
Numeric pain scale.
A client is beginning therapy with montelukast (Singulair) PO 10 mg once a
day in the evening. The client asks the nurse, "When should I begin to feel
better?" How should the nurse respond?
Immediately.
Within 24 hours.
In about 12 hours.
30 minutes to 1 hour.
Within 24 hours.
What is the expected outcome of esomeprazole (Nexium) when prescribed for
a client with gastroesophageal reflux disease (GERD)?
Promotion of rapid tissue healing.
Increased gastric emptying.
Improved esophageal peristalsis.
Neutralization of gastric secretions.
Promotion of rapid tissue healing.
A client at 30-weeks gestation is in preterm labor. The healthcare provider
prescribes two 12-mg doses of betamethasone (Celestone) intramuscularly
every 12 hours. The client asks the nurse why she is receiving the Celestone.
What information should the nurse use to explain the action of the
HESI PHARMACOLOGY EXAM PRACTICE 2026 (NCLEX PN)
2 VERSIONS ACTUAL QUESTIONS EXAM 2026-2027 ALL
QUESTIONS WITH ANSWERS EXAM 2026 LATEST EDITION
SOLVED QUESTIONS & ANSWERS VERIFIED
A client receives a new prescription for ciprofloxacin (Cipro), a synthetic
quinolone. When teaching about this drug, which information in the client's
history requires special emphasis by the nurse?
Snacks on dairy products such as yogurt or ice cream.
Previously had a mild allergic reaction to a cephalosporin.
Consumes alcoholic drinks occasionally on the weekends.
Works twenty hours a week as a lifeguard at the local pool.
Works twenty hours a week as a lifeguard at the local pool.
A client who is receiving chemotherapy is prescribed ondansetron (Zofran).
What side effect should the nurse include in the teaching plan?
Headache.
Dry mouth.
Impaired taste.
Blurred vision.
Headache.
Which heparin concentration should the nurse use to convert an intravenous
site to a heparin lock?
10 units/ml.
100 units/ml.
, Page 2 of 177
1000 units/ml.
10,000 units/ml.
100 units/ml.
Which findings should the nurse identify in an adult client with possible
chronic salicylate intoxication?
Tinnitus and hearing loss.
Photosensitivity and nervousness.
Acute gastrointestinal bleeding and anorexia.
Hyperventilation and central nervous system effects.
Tinnitus and hearing loss.
A client is admitted for atrial fibrillation, and the healthcare provider prescribes
disopyramide (Norpace). After explaining the action of this antidysrhythmic
agent, which complaint should the nurse instruct the client to report?
Joint pain.
Dizziness or muscle weakness.
Daily weight gain of 2 pounds.
Dry mouth.
Daily weight gain of 2 pounds.
An emergency department triage nurse is interviewing a female client who has
a history of epilepsy with tonic-clonic seizures controlled by phenytoin
(Dilantin). Which information is most significant in planning this client's care?
She has missed 2 menstrual periods.
She has had no dental care for several years.
She ran out of her medication 4 days ago.
She has smoked 3 packs of cigarettes a day for 10 years.
She ran out of her medication 4 days ago.
The healthcare provider prescribes pyridostigmine bromide (Mestinon) tablets
for a client with myasthenia gravis (MG). What instruction should the nurse
provide this client?
Increase activity in the afternoon when the medication is most effective.
, Page 3 of 177
Take the medication 30 to 45 minutes before eating.
Use a PRN dose for increasing muscular weakness or fasciculations.
Give the client a dietary guide that describes low-protein foods.
Take the medication 30 to 45 minutes before eating.
What action should the nurse implement to provide analgesic titration for a
client in pain ?
Teach the client to increase the time range between doses of pain medication.
Monitor the effects of continuous intravenous infusion of narcotic analgesics.
Plan with the client how to use a specific total dose of analgesic over a 24-
hour period.
Determine the optimal analgesic dosage required that causes the least side
effects.
Determine the optimal analgesic dosage required that causes the least side effects.
Which common side effect should the nurse alert a female client about when
medroxyprogesterone (Depo-Provera) is prescribed?
Leg or calf pain.
Headaches or visual changes.
Vaginal bleeding after discontinuing the medication.
Jaundice during the first 3 weeks of administration.
Vaginal bleeding after discontinuing the medication.
Miotic drug therapy for the treatment of glaucoma is based chiefly upon which
physiologic action?
Enhancing aqueous humor outflow.
Inhibiting aqueous humor production.
Maintaining intraocular pressure.
Preventing extraocular infection.
Enhancing aqueous humor outflow.
A client receives a new prescription for nitroglycerin (Nitrostat) tablets. Which
instruction should the nurse include in this client's teaching?
Take the medication at least an hour before every meal.
, Page 4 of 177
Monitor your pulse for 60 seconds before administration.
Place under the tongue as needed every 5 minutes up to 3 times.
Resume normal activities after chest pain relief is obtained.
Place under the tongue as needed every 5 minutes up to 3 times.
The nurse administers the initial dose of a fentanyl (Duragesic) transdermal
patch to a client with chronic pain. When monitoring the client an hour later,
which assessment is most important for the nurse to obtain?
Level of consciousness.
Moistness of mucosa.
Bowel sound activity.
Numeric pain scale.
Numeric pain scale.
A client is beginning therapy with montelukast (Singulair) PO 10 mg once a
day in the evening. The client asks the nurse, "When should I begin to feel
better?" How should the nurse respond?
Immediately.
Within 24 hours.
In about 12 hours.
30 minutes to 1 hour.
Within 24 hours.
What is the expected outcome of esomeprazole (Nexium) when prescribed for
a client with gastroesophageal reflux disease (GERD)?
Promotion of rapid tissue healing.
Increased gastric emptying.
Improved esophageal peristalsis.
Neutralization of gastric secretions.
Promotion of rapid tissue healing.
A client at 30-weeks gestation is in preterm labor. The healthcare provider
prescribes two 12-mg doses of betamethasone (Celestone) intramuscularly
every 12 hours. The client asks the nurse why she is receiving the Celestone.
What information should the nurse use to explain the action of the
