MARYVILLE PSYCHOPHARMACOLOGY CORE EXAM
MANUAL QUESTIONS AND ANSWERS SURE A+
✔✔What medical emergency is associated with antipsychotic use? - ✔✔Neuroleptic
Malignant Syndrome (NMS)
Sx - hyperthermia, muscle rigidity, cramps, tremor, severe HTN or hypotenions,
tachycardia, delirium, seizures, agitation
Dx - high suspicion on any pt taking antipsychotics, elevated CPK and WBCs
Tx - d/c tx, start IV Dantrolene
✔✔SSRIs - ✔✔Fluoxetine (Prozac), Escitalopram [Lexapro], Citalopram [Celexa],
Fluvoxamine [Luvox], Paroxetine [Paxil], Sertraline [Zoloft]
✔✔What are the indications for SSRIs? - ✔✔1. Depression (1st line)
2. Long term management of anxiety disorders
3. Bulimia nervosa
✔✔What are the common AE of SSRIs? - ✔✔1. Sexual dysfunction
2. GI effects - decrease appetite, diarrhea
3. Serotonin Syndrome (interactions w/ MAOIs, other SSRIs)
4. Withdrawal
✔✔What is the MOA of TCAs? - ✔✔Block NE and serotonin transporter site
✔✔TCAs - ✔✔Imipramine, amitryptiline, doxepin, clomipramine, nortriptyline
✔✔What are the indications for TCAs? - ✔✔1. 2nd line tx for MDD
2. 2nd line tx for OCD (clomipramine)
3. 2nd line tx for childhood enuresis (imipramine)
4. 2nd line tx for pain disorders (amitriptyline)
✔✔What are the AE of TCAs? - ✔✔Anticholinergic side effects (orthostatic
hypotension), high mortality rate in overdose
✔✔MAOIs - ✔✔Phenelzine [Nardil], Selegiline [Eldepryl]
✔✔What are the indications for MAOIs? - ✔✔1. Depression w/ atypical features
2. Parkinsons disease
✔✔What are the AE of MAOIs? - ✔✔HTN Emergency - increased risk when taken w/
tyrosine foods, stimulant Rx, and some medications for asthma
✔✔What medication is favorable for patients with MDD who suffer sexual dysfunction
on SSRIs? - ✔✔Bupropion [Wellbutrin]
MANUAL QUESTIONS AND ANSWERS SURE A+
✔✔What medical emergency is associated with antipsychotic use? - ✔✔Neuroleptic
Malignant Syndrome (NMS)
Sx - hyperthermia, muscle rigidity, cramps, tremor, severe HTN or hypotenions,
tachycardia, delirium, seizures, agitation
Dx - high suspicion on any pt taking antipsychotics, elevated CPK and WBCs
Tx - d/c tx, start IV Dantrolene
✔✔SSRIs - ✔✔Fluoxetine (Prozac), Escitalopram [Lexapro], Citalopram [Celexa],
Fluvoxamine [Luvox], Paroxetine [Paxil], Sertraline [Zoloft]
✔✔What are the indications for SSRIs? - ✔✔1. Depression (1st line)
2. Long term management of anxiety disorders
3. Bulimia nervosa
✔✔What are the common AE of SSRIs? - ✔✔1. Sexual dysfunction
2. GI effects - decrease appetite, diarrhea
3. Serotonin Syndrome (interactions w/ MAOIs, other SSRIs)
4. Withdrawal
✔✔What is the MOA of TCAs? - ✔✔Block NE and serotonin transporter site
✔✔TCAs - ✔✔Imipramine, amitryptiline, doxepin, clomipramine, nortriptyline
✔✔What are the indications for TCAs? - ✔✔1. 2nd line tx for MDD
2. 2nd line tx for OCD (clomipramine)
3. 2nd line tx for childhood enuresis (imipramine)
4. 2nd line tx for pain disorders (amitriptyline)
✔✔What are the AE of TCAs? - ✔✔Anticholinergic side effects (orthostatic
hypotension), high mortality rate in overdose
✔✔MAOIs - ✔✔Phenelzine [Nardil], Selegiline [Eldepryl]
✔✔What are the indications for MAOIs? - ✔✔1. Depression w/ atypical features
2. Parkinsons disease
✔✔What are the AE of MAOIs? - ✔✔HTN Emergency - increased risk when taken w/
tyrosine foods, stimulant Rx, and some medications for asthma
✔✔What medication is favorable for patients with MDD who suffer sexual dysfunction
on SSRIs? - ✔✔Bupropion [Wellbutrin]
