NURS 5220 Test 1 Questions and Answers –
Comprehensive Nursing Exam.
Graduate Nursing Pathophysiology & Pharmacology
Time Limit: 75 minutes | Total Questions: 50 | Passing: 80% (A-Grade Standard)
Student Name: _______________________________
Date: _______________________________
Score: _______ / 50 = _______%
EXAM INSTRUCTIONS
• Read each question carefully before selecting your answer.
• For multiple choice questions, select the ONE best answer.
• For Select All That Apply (SATA) questions, select ALL correct options. Partial credit is NOT given.
• For clinical scenarios, apply pathophysiology principles and evidence-based practice.
• Manage your time: approximately 1.5 minutes per question.
• No external resources, notes, or devices permitted during this exam.
• Write your answer choice(s) in the space provided or mark on separate answer sheet.
DOMAIN I: CELLULAR ADAPTATION, INJURY & NEOPLASIA
Question 1
A 65-year-old with chronic GERD undergoes endoscopy. Biopsy shows replacement of squamous
epithelium with columnar epithelium containing goblet cells. This is:
A. Dysplasia
B. Metaplasia
C. Hyperplasia
D. Anaplasia
Your Answer: _______________
Question 2
A patient with left ventricular hypertrophy secondary to chronic hypertension demonstrates which
type of cellular adaptation?
, A. Atrophy
B. Hypertrophy
C. Hyperplasia
D. Metaplasia
Your Answer: _______________
Question 3
A patient with bacterial pneumonia has fever and elevated C-reactive protein (CRP). These are
primarily caused by:
A. Histamine
B. Prostaglandins
C. Cytokines (IL-1, IL-6, TNF)
D. Leukotrienes
Your Answer: _______________
Question 4
Which type of necrosis is characterized by cheese-like, granular debris and is associated with
tuberculosis?
A. Coagulative necrosis
B. Liquefactive necrosis
C. Caseous necrosis
D. Fat necrosis
Your Answer: _______________
Question 5
Apoptosis differs from necrosis in that apoptosis:
A. Triggers an inflammatory response
B. Results from acute cellular injury
C. Is a programmed cell death without inflammation
D. Produces cellular swelling and membrane rupture
Your Answer: _______________
Question 6
A 55-year-old with chronic alcohol use has elevated serum amylase and lipase. CT shows
peripancreatic fat stranding. The type of necrosis most likely present is:
A. Coagulative
B. Liquefactive
C. Caseous
, D. Fat necrosis
Your Answer: _______________
DOMAIN II: INFLAMMATION & IMMUNITY
Question 7
Both parents are unaffected carriers of cystic fibrosis. Their next child has what chance of having
the disease?
A. 0%
B. 25%
C. 50%
D. 75%
Your Answer: _______________
Question 8
Hemophilia A is inherited in which pattern?
A. Autosomal dominant
B. Autosomal recessive
C. X-linked recessive
D. Mitochondrial
Your Answer: _______________
Question 9
A patient develops hives, wheezing, and hypotension within minutes of peanut ingestion. This
represents which type of hypersensitivity reaction?
A. Type I
B. Type II
C. Type III
D. Type IV
Your Answer: _______________
Question 10
Contact dermatitis from poison ivy is classified as:
A. Type I hypersensitivity
B. Type II hypersensitivity
C. Type III hypersensitivity
D. Type IV hypersensitivity
Comprehensive Nursing Exam.
Graduate Nursing Pathophysiology & Pharmacology
Time Limit: 75 minutes | Total Questions: 50 | Passing: 80% (A-Grade Standard)
Student Name: _______________________________
Date: _______________________________
Score: _______ / 50 = _______%
EXAM INSTRUCTIONS
• Read each question carefully before selecting your answer.
• For multiple choice questions, select the ONE best answer.
• For Select All That Apply (SATA) questions, select ALL correct options. Partial credit is NOT given.
• For clinical scenarios, apply pathophysiology principles and evidence-based practice.
• Manage your time: approximately 1.5 minutes per question.
• No external resources, notes, or devices permitted during this exam.
• Write your answer choice(s) in the space provided or mark on separate answer sheet.
DOMAIN I: CELLULAR ADAPTATION, INJURY & NEOPLASIA
Question 1
A 65-year-old with chronic GERD undergoes endoscopy. Biopsy shows replacement of squamous
epithelium with columnar epithelium containing goblet cells. This is:
A. Dysplasia
B. Metaplasia
C. Hyperplasia
D. Anaplasia
Your Answer: _______________
Question 2
A patient with left ventricular hypertrophy secondary to chronic hypertension demonstrates which
type of cellular adaptation?
, A. Atrophy
B. Hypertrophy
C. Hyperplasia
D. Metaplasia
Your Answer: _______________
Question 3
A patient with bacterial pneumonia has fever and elevated C-reactive protein (CRP). These are
primarily caused by:
A. Histamine
B. Prostaglandins
C. Cytokines (IL-1, IL-6, TNF)
D. Leukotrienes
Your Answer: _______________
Question 4
Which type of necrosis is characterized by cheese-like, granular debris and is associated with
tuberculosis?
A. Coagulative necrosis
B. Liquefactive necrosis
C. Caseous necrosis
D. Fat necrosis
Your Answer: _______________
Question 5
Apoptosis differs from necrosis in that apoptosis:
A. Triggers an inflammatory response
B. Results from acute cellular injury
C. Is a programmed cell death without inflammation
D. Produces cellular swelling and membrane rupture
Your Answer: _______________
Question 6
A 55-year-old with chronic alcohol use has elevated serum amylase and lipase. CT shows
peripancreatic fat stranding. The type of necrosis most likely present is:
A. Coagulative
B. Liquefactive
C. Caseous
, D. Fat necrosis
Your Answer: _______________
DOMAIN II: INFLAMMATION & IMMUNITY
Question 7
Both parents are unaffected carriers of cystic fibrosis. Their next child has what chance of having
the disease?
A. 0%
B. 25%
C. 50%
D. 75%
Your Answer: _______________
Question 8
Hemophilia A is inherited in which pattern?
A. Autosomal dominant
B. Autosomal recessive
C. X-linked recessive
D. Mitochondrial
Your Answer: _______________
Question 9
A patient develops hives, wheezing, and hypotension within minutes of peanut ingestion. This
represents which type of hypersensitivity reaction?
A. Type I
B. Type II
C. Type III
D. Type IV
Your Answer: _______________
Question 10
Contact dermatitis from poison ivy is classified as:
A. Type I hypersensitivity
B. Type II hypersensitivity
C. Type III hypersensitivity
D. Type IV hypersensitivity
