Aggregation is mediated by ______ resulting in _____ blood flow.
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TXA2
decreased
HbA2
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Adult Hb = 2 alpha, 2 delta chains
- <3% of total adult Hb
- Glycosylation is marker for chronically high blood sugar
,Anemia of Chronic Disease is associated w/ what conditions?
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RA
SLE
Cancer/Neoplasia
Chronic Kidney Disease
Etiology of Microcytic, Hypochromic Anemia
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(A-LIST)
Anemia of Chronic Disease (late in disease)
Lead Poisoning
Iron Deficiency Anemia (late in disease)
Sideroblastic Anemia
Thalassemia
Abnormal platelet activation leads to ...
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, Arterial Occlusion
- Coronary arteries = MI
- CNS = stroke
- Peripheral arteries = gangrenous limbs
Alpha Thalassemia: 4 gene deletion
a. Pathophysiology
b. S/S
c. Electrophoresis
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Hydrops Fetalis
a. (--/--)
- No alpha globin formed
- Gamma chains aggregate forming tetramers and damaging RBCs in utero
b. Incompatible w/ life
c. Hb Barts (gamma 4 tetramers)
Target Cells associated w/:
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(HALT)
HbC disease
Asplenia
Liver Disease
Thalassemia
, Hereditary Disorders leading to Hypercoagulability
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- Anti-Thrombin 3 Deficiency
- Factor 5 Leiden
- Protein C or S Deficiency
- Prothrombin Gene mutation
- Anti-phospholipid Syndrome
Hemophilia B
a. Inheritance
b. Etiology
c. Tx
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a. X-linked
- Females can experience lyonization and cause low levels of factor 8
b. Factor 9 deficiency
c. Desmopressin + Factor 9
What is Glanzmann thrombasthenia?
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Give this one a try later!
TXA2
decreased
HbA2
Give this one a try later!
Adult Hb = 2 alpha, 2 delta chains
- <3% of total adult Hb
- Glycosylation is marker for chronically high blood sugar
,Anemia of Chronic Disease is associated w/ what conditions?
Give this one a try later!
RA
SLE
Cancer/Neoplasia
Chronic Kidney Disease
Etiology of Microcytic, Hypochromic Anemia
Give this one a try later!
(A-LIST)
Anemia of Chronic Disease (late in disease)
Lead Poisoning
Iron Deficiency Anemia (late in disease)
Sideroblastic Anemia
Thalassemia
Abnormal platelet activation leads to ...
Give this one a try later!
, Arterial Occlusion
- Coronary arteries = MI
- CNS = stroke
- Peripheral arteries = gangrenous limbs
Alpha Thalassemia: 4 gene deletion
a. Pathophysiology
b. S/S
c. Electrophoresis
Give this one a try later!
Hydrops Fetalis
a. (--/--)
- No alpha globin formed
- Gamma chains aggregate forming tetramers and damaging RBCs in utero
b. Incompatible w/ life
c. Hb Barts (gamma 4 tetramers)
Target Cells associated w/:
Give this one a try later!
(HALT)
HbC disease
Asplenia
Liver Disease
Thalassemia
, Hereditary Disorders leading to Hypercoagulability
Give this one a try later!
- Anti-Thrombin 3 Deficiency
- Factor 5 Leiden
- Protein C or S Deficiency
- Prothrombin Gene mutation
- Anti-phospholipid Syndrome
Hemophilia B
a. Inheritance
b. Etiology
c. Tx
Give this one a try later!
a. X-linked
- Females can experience lyonization and cause low levels of factor 8
b. Factor 9 deficiency
c. Desmopressin + Factor 9
What is Glanzmann thrombasthenia?
Give this one a try later!
