1|Page
NURS 5334 FINAL EXAM 2026 new
QUESTIONS WITH COMPLETE
ANSWERS(VERIFIED NUR ANSWERS)
already graded A+, Exams of Nursing
**IV route dosing (parenteral) - --ANS---Goes directly to the body. Results in 100%
bioavailability. Decreasing first pass effect, decreasing absorption limitations, extractions...
By passes absorption and extraction.
Loading dose - --ANS---[Peak] concentration X Vd divided by bioavailability
Maintenance dose - --ANS---[Peak] X Clearance divided by bioavailability
Clearance is affected by - --ANS---Kidney function
**If a patient has kidney disease you would - --ANS---Decrease your maintenance dose; loading
dose stays the same (doesn't affect clearance)
, 2|Page
Metabolism - --ANS---
Phase 1 reaction - --ANS---Oxidation, reduction, hydrolytic (CYP450 system in the liver) Zone
3: Hepatic acinus where drugs are modified
Goal is to made polar, water soluble molecules
Phase 2 reaction - --ANS---Gluceronudation, acetylation, sulfation (inactive metabolites)
**First pass effect - --ANS---Liver encounters drug before it enters the system. Enteral
drugs...intestine to portal circulation (SI to liver)...hepatic portal vein...central vein...hepatic
vein...IVC...heart...body
Metabolism - --ANS---Occurs in the liver (hepatic portal vein...central vein.
**Elimination - --ANS---Two routes: through the kidney (urine) and GI (bile, feces)
**Clearance - --ANS---Elimination of drug divided by the concentration of the drug in the
plasma.
Elimination constant - --ANS---Clearance divided by volume of distribution.
1/2 life (T 1/2) - --ANS---Time it takes to get rid of half of the drug
0.693 X Vd divided by clearance
NURS 5334 FINAL EXAM 2026 new
QUESTIONS WITH COMPLETE
ANSWERS(VERIFIED NUR ANSWERS)
already graded A+, Exams of Nursing
**IV route dosing (parenteral) - --ANS---Goes directly to the body. Results in 100%
bioavailability. Decreasing first pass effect, decreasing absorption limitations, extractions...
By passes absorption and extraction.
Loading dose - --ANS---[Peak] concentration X Vd divided by bioavailability
Maintenance dose - --ANS---[Peak] X Clearance divided by bioavailability
Clearance is affected by - --ANS---Kidney function
**If a patient has kidney disease you would - --ANS---Decrease your maintenance dose; loading
dose stays the same (doesn't affect clearance)
, 2|Page
Metabolism - --ANS---
Phase 1 reaction - --ANS---Oxidation, reduction, hydrolytic (CYP450 system in the liver) Zone
3: Hepatic acinus where drugs are modified
Goal is to made polar, water soluble molecules
Phase 2 reaction - --ANS---Gluceronudation, acetylation, sulfation (inactive metabolites)
**First pass effect - --ANS---Liver encounters drug before it enters the system. Enteral
drugs...intestine to portal circulation (SI to liver)...hepatic portal vein...central vein...hepatic
vein...IVC...heart...body
Metabolism - --ANS---Occurs in the liver (hepatic portal vein...central vein.
**Elimination - --ANS---Two routes: through the kidney (urine) and GI (bile, feces)
**Clearance - --ANS---Elimination of drug divided by the concentration of the drug in the
plasma.
Elimination constant - --ANS---Clearance divided by volume of distribution.
1/2 life (T 1/2) - --ANS---Time it takes to get rid of half of the drug
0.693 X Vd divided by clearance
