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AORN Periop 101 | 144 Most Tested Questions & Answers 2026 | Latest Update | Exam Prep

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Prepare confidently for your AORN Periop 101 Exam with this focused 2026 collection of 144 Most Tested Questions & Answers designed to help perioperative nursing students and new OR nurses strengthen core knowledge, improve clinical reasoning, and build exam confidence. This high-yield resource combines frequently tested exam-style questions with clear answers to support efficient studying and stronger retention. This guide is structured to reflect key concepts covered in the Periop 101 curriculum, helping learners apply perioperative nursing principles in real exam scenarios while reinforcing patient safety and operating room best practices. Topics Covered Include: Preoperative patient assessment and preparation Surgical asepsis and sterile field management Infection prevention and surgical site safety Surgical instrumentation and equipment handling Patient positioning and pressure injury prevention Anesthesia concepts and perioperative monitoring Surgical counts, specimen handling, and documentation Team communication and perioperative safety protocols Evidence-based perioperative nursing practices Operating room workflow and standards of care Ideal For: AORN Periop 101 final exam preparation New OR nurse orientation and onboarding Perioperative nursing students and trainees High-yield exam revision before testing Strengthening perioperative clinical decision-making Key Benefits: 144 high-yield exam-style questions and answers Focused on frequently tested perioperative topics Reinforces critical thinking and clinical application Supports fast, efficient, and structured studying Updated for 2026 perioperative nursing standards This resource is designed to improve confidence, reinforce essential OR nursing knowledge, and maximize readiness for the AORN Periop 101 exam.

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AORN Periop 101 | 144 Most Tested Questions &
Answers 2026 | Latest Update | Exam Prep
1. Which of the following is NOT a component of safe handling of medical gas
cylinders ?

Checking the color coding before use

Checking the written labels before use

Manually tightening fittings and hoses before use

Checking the pin - index safety system before use

2. What is the term used to describe the administration of sedatives by an
anesthesiologist with additional medical services as needed?

Monitored anesthesia care

Moderate sedation

General anesthesia

Local anesthesia injection

3. Monitored anesthesia care differs from moderate sedation in that monitored
anesthesia care:

is used as an adjunct to spinal anesthesia.

requires the introduction of an anesthetic agent into the epidural
space

may result in the administration of general anesthesia.

is a type of regional anesthesia.

,4. Which method is considered incorrect for applying cleaning solutions in a
surgical environment?

Cleaning equipment should not be shared between restricted and
semi-restricted areas.

Label secondary containers when a product is poured from its original
container.

Cleaning with a wet mop reduces the spread of contamination

Use a spray bottle to disperse solution

5. What characterizes Family-Centered Care in healthcare?

A model that excludes patient and family input in the healthcare
process.

An approach that prioritizes individual care without considering family
involvement.

A method solely focused on healthcare providers' decision-making.

An approach grounded in mutually beneficial partnerships among
patients, families, and healthcare providers, recognizing the vital
role of the family in ensuring the health and well-being of patients
of all ages.

6. In a scenario where a surgical team is preparing for an operation, what would
be the best practice for applying cleaning solutions to ensure safety and
minimize contamination?

Use spray bottles to quickly apply cleaning solutions to surfaces.

Label secondary containers and avoid using spray bottles for
dispersing solutions.

Use a wet mop to clean surfaces without any additional precautions.

, Share cleaning equipment between restricted and semi-restricted
areas to save time.

7. Describe why using a spray bottle for cleaning solutions may be
inappropriate in a surgical setting.

Using a spray bottle is an efficient way to apply cleaning solutions
evenly.

Using a spray bottle can aerosolize cleaning solutions, increasing
the risk of contamination and exposure.

Using a spray bottle helps to minimize the amount of cleaning solution
used.

Using a spray bottle is standard practice in all healthcare settings.

8. The purpose of surgical draping is to

Create a sterile field around the incision site

Create a barrier to bacterial migration

Reduce the chance of postoperative wound infection

All of the above

9. What is a key characteristic of a zipper closure in skin closure options?

A stand-alone skin approximation method.

Easier to remove than sutures.

Limited to use for superficial wounds.

Distributes skin-stretching forces over a side surface area.

10. What is the recommended action regarding an implanted IED during
monopolar electrosurgery?

, Place the dispersive pad as close as possible to the IED

Verify that the IED and its leads are between the IED and the
dispersive pads

Inactivate the IED, when possible

Use the ESU at the highest power setting

11. Describe how extravasation can lead to intraabdominal compartment
syndrome in a surgical patient.

Extravasation increases blood volume, resulting in hypervolemia.

Extravasation causes pulmonary complications due to fluid
accumulation in the lungs.

Extravasation can cause swelling and increased pressure in the
abdominal cavity, leading to intraabdominal compartment
syndrome.

Extravasation leads to fluid loss, resulting in hyponatremia.

12. What is the definition of fast-tracking in the context of post-anesthesia care?

A method that requires a nursing hand-off

The patient's transfer to phase II Post anesthesia care

A procedure that does not include patient and family education

A process that requires a 1:1 nurse-to-patient ratio

13. In a surgical procedure, if a patient has a wound that requires significant
tension management, which skin closure option would be most appropriate
and why?

Traditional sutures, as they are easier to apply.

Adhesive strips, because they are less invasive.

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