NR 507 midterm Study guide 2023
Hypersensitivity: Type 1 - -Mediated IgE
-inflammation due to mast cell degranultion
-anaphylactic, asthma, hay fever
treatment: epinephrine
Hypersensitivity: Type 2 - -Cytotoxic reaction: tissue specific
-binds to the antigen ON THE CELL SURFACE
-macrophages are primary effectors cells involved
cause tissue damage or alter function
Hypersensitivity 2 - -Graves Disease (hyperthyroidism) -alters function not destroy
-blood transfusions reaction- transfused erythrocytes are destroyed by agglutination or
lysis
-drug allergies
-hemolytic anemia
Hypersensitivity: type 3 - -Not organ specific
-antibody binds to soluble antigen OUTSIDE THE CELL SURFACE that was released
into the blood or bodily fluids, and the complex is then deposited in the tissues
Hypersensitivity: Type 3 - -rheumatoid arthritis
-Systemic Lupus Erythematosus (SLE)
-Raynaud's
Hives (urticaria) - Hypersensitivity Type 1
First responders to innate the immune system - Neutrophils
Allergic contact dermatitis - Hypersensitivity Type IV
Type 2 cytotoxic hypersensitivity mediated by: - -IgG IgM
-macrophages are primary effort cells
-
Serum Sickness - type 3 hypersensitivity
Hypersensitivity IV, - -is more of a delayed immune response.
-mediated T-cells attack tissue directly (no antibodies)
Autoimmune - -diseases in which the body makes antibodies directed against its own
tissues
-
, Primary immunodeficiency - -Genetic; inherited
-result of single gene defects
-B and T cell deficiencies
secondary immunodeficiency - -acquired
Common cause of secondary immunodeficiency - Malnutrition
Most patients diagnosed with SLE will have a positive ? - antinuclear antibody (ANA)
SLE (lupus) - -Facial rash
-vasculitis
- tissue inflammation
Renal disease associated with autoimmunity? - Glomerulonephritis
Sjogren's syndrome - Inflammation in salivary and lacrimal glands
SLE - Autoantibodies and auto-active t-cells against DNA and nucleoprotein
Sjögren's syndrome immune changes: - Autoantibodies and auto-reactive t-cells against
apoptotic cells
rheumatoid arthritis manifestations: - Joint inflammation, stiffness, pain, loss of range of
motion
Rheumatoid Arthritis immune changes: - T-cells and B cells against joint associated
antigens
MS manifestations - Formation of sclerotic plaque in the brain, leads to Muscle
weakness and ataxia
MS immune changes - T-cells against brain antigens
___ measures the average size of RBCs - MCV
Anemia occur by... - -impaired RBC production
-excessive blood loss
- increased RBC production
microlytic anemia is characterized by hyper chromic RBS: - Hereditary spherocytosis
Anemia - -"without blood"
4.7-6.1mcl - Normal for men RBC
Hypersensitivity: Type 1 - -Mediated IgE
-inflammation due to mast cell degranultion
-anaphylactic, asthma, hay fever
treatment: epinephrine
Hypersensitivity: Type 2 - -Cytotoxic reaction: tissue specific
-binds to the antigen ON THE CELL SURFACE
-macrophages are primary effectors cells involved
cause tissue damage or alter function
Hypersensitivity 2 - -Graves Disease (hyperthyroidism) -alters function not destroy
-blood transfusions reaction- transfused erythrocytes are destroyed by agglutination or
lysis
-drug allergies
-hemolytic anemia
Hypersensitivity: type 3 - -Not organ specific
-antibody binds to soluble antigen OUTSIDE THE CELL SURFACE that was released
into the blood or bodily fluids, and the complex is then deposited in the tissues
Hypersensitivity: Type 3 - -rheumatoid arthritis
-Systemic Lupus Erythematosus (SLE)
-Raynaud's
Hives (urticaria) - Hypersensitivity Type 1
First responders to innate the immune system - Neutrophils
Allergic contact dermatitis - Hypersensitivity Type IV
Type 2 cytotoxic hypersensitivity mediated by: - -IgG IgM
-macrophages are primary effort cells
-
Serum Sickness - type 3 hypersensitivity
Hypersensitivity IV, - -is more of a delayed immune response.
-mediated T-cells attack tissue directly (no antibodies)
Autoimmune - -diseases in which the body makes antibodies directed against its own
tissues
-
, Primary immunodeficiency - -Genetic; inherited
-result of single gene defects
-B and T cell deficiencies
secondary immunodeficiency - -acquired
Common cause of secondary immunodeficiency - Malnutrition
Most patients diagnosed with SLE will have a positive ? - antinuclear antibody (ANA)
SLE (lupus) - -Facial rash
-vasculitis
- tissue inflammation
Renal disease associated with autoimmunity? - Glomerulonephritis
Sjogren's syndrome - Inflammation in salivary and lacrimal glands
SLE - Autoantibodies and auto-active t-cells against DNA and nucleoprotein
Sjögren's syndrome immune changes: - Autoantibodies and auto-reactive t-cells against
apoptotic cells
rheumatoid arthritis manifestations: - Joint inflammation, stiffness, pain, loss of range of
motion
Rheumatoid Arthritis immune changes: - T-cells and B cells against joint associated
antigens
MS manifestations - Formation of sclerotic plaque in the brain, leads to Muscle
weakness and ataxia
MS immune changes - T-cells against brain antigens
___ measures the average size of RBCs - MCV
Anemia occur by... - -impaired RBC production
-excessive blood loss
- increased RBC production
microlytic anemia is characterized by hyper chromic RBS: - Hereditary spherocytosis
Anemia - -"without blood"
4.7-6.1mcl - Normal for men RBC
