Questions and Guide Answers
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1. How do antigout medications work?
Answer: by inhibiting the infiltration and phagocytosis of leukocytes, thus decreasing the breakdown of
uric acid to urate crystals.
2. Deposition of urate crystals causes
Answer: pain and inflammation
3. What is Colchicine
Answer: anti-gout medication
4. how does Colchicine work?
Answer: Works by inhibiting inflammation, reducing pain and swelling
5. common side effects of Colchicine
,Answer: GI problems (diarrhea) use with caution in elderly Also can cause blood dyscrasias &
abdominal pain
6. patient education with Colchicine
Answer: Can be given with food & milk to decrease GI issues Avoid beer, ale, & wine may
cause gout attack
Increase fluid intake increases excretion of uric acid Avoid
smoked meats & high-protein diets
7. Low dose of Colchicine
Answer: Low dose colchicine is 1.2mg followed by 0.6mg one hour later or 1.8
milligrams total
8. High dose of Colchicine
Answer: high dose colchicine is 1.2mg followed by 0.6mg every four to six hours; or
4.8mg total.
9. Difference between high dose and low dose Colchicine
Answer: The ditterence between the two is low dose is as ettective as high dose with a lower side
ettect profile.
10. Lab values to monitor with Colchicine
Answer: Check renal function test, BUN, Creatine
,11. Patient education with Colchicine
Answer: Almost always causes some degree of diarrhea, make sure patients are aware of this side
ettect
12. Patient education with Febuxostat (Uloric)
Answer: Gout may worsen with therapy initially
13. Dietary changes to decrease gout attacks and uric acid deposits.
Answer: Avoid beer, ale, & wine
Increase fluid intake increases excretion of uric acid Avoid
smoked meats & high-protein diets
14. WHO 3 step ladder for pain medication
Answer:
15. What is not a first line for pain medication?
Answer: Narcotics
16. Recommendations for pain treatment
Answer: You want to start with NSAIDs first and then work your way up from there.
17. types of Corticosteroid treatment
Answer: Prednisone, Cortisone, Dexamethasone
18. how do Corticosteroids work?
, Answer: Suppress the inflammatory & immune systems by inhibiting the synthesis of chemical
mediators.
19. what are the chemical mediators that Corticosteroids work on?
Answer: Prostaglandins, leukotrienes, & histamines
20. Corticosteroids and inflammation
Answer: Decreases inflammation which decreases swelling, warmth, redness, & pain.
21. Uses for corticosteroid treatment
Answer: Addison's disease, hormone replacement, cancer therapy SLE, arthritis, IBD, & to suppress
graft rejection
22. contraindications for corticosteroid treatment
Answer: Systemic fungal infections & with live vaccine
23. Use corticosteroids cautiously with
Answer: Pregnancy, kids, HTN, heart failure, renal impairment, & with infections resistant to
treatment
24. Patient education with corticosteroids
Answer: Don't discontinue abruptly, doses may need increased during stress, symptoms of Cushing's
and GI bleeding
25. Problem with taking Corticosteroids for greater than 6 months