NR 566 Week 3 Chapter 16 Notes Drugs affecting the Cardiovascular Renal Systems

NR 566 Week 3 Chapter 16 Notes - Drugs affecting the Cardiovascular & Renal Systems Chapter 16: Drugs Affecting the Cardiovascular and Renal Systems ACEIs, ARBs and Direct Renin Inhibitors: Act on the RAA system to reduce pressure by decreasing sodium and water retention, decreasing vasoconstriction, and increasing vasodilation. ACEI: PRILs • MOAs: Improve oxygenation to heart muscle and decrease inappropriate remodeling of the heart muscle after MI or with HF. Decrease production of ATII and Aldosterone. • Indications: Hypertension. Young, white, DM, MI, or HF. AA=increased angioedema. • Absolute contraindications: Bilateral renal artery stenosis, angioedema, pregnancy • Precautions: impaired renal function, hypovolemic and hyponatremic states. Hyperkalemia, hepatic impairments • Monitoring: BP, weight, fluid status, renal function, potassium, WBC for neutropenia. • Adverse drug reactions: Angioedema. Hypotension (dizzy, HA, fatigue). Dry hacking cough within first week of therapy. Rash, photosensitivity. • Drug interactions: Diuretics should be stopped for 2-3 days before starting meds. Increase doses in 1-2 weeks intervals. NSAIDS interact. No salt substitutes. ARBSs: ARTANs • MOAs: Block AT