ADVANCED IMMUNOLOGY
AND CELL BIOLOGY
By Maite Erguin
Main lecturer: Reina Mebius
Master’s in Biomedical Sciences. 2021-2022
Vrije Universiteit Amsterdam
,Contents
1. INTRODUCTION (Reina Mebius, 6th September).............................................................................2
2. DENDRITIC CELLS AND MIGRATION, HOST INNATE IMMUNE RECEPTORS (Sanne Duinkerken, 7th
September) ......................................................................................................................................19
3. T CELL PRIMING IN THE COVID-19 ERA (Joke de Haan, 13th September) ......................................32
4. (AUTO)ANTIBODIES IN HEALTH AND DISEASE (Marjolein van Egmond, 20th September,) ...........41
5. IMMUNOMETABOLISM (Jan Van den Bossche, 23rd September) .................................................50
6. IMMUNE RESPONSES TO GLYCOLIPIDS AND POLYSACCHARIDES (Sandra van Vliet, 29th
September) ......................................................................................................................................56
7. IMMUNE DEFICIENCIES (Sergey Nejentsev, 4th October) .............................................................63
8. LYMPH NODE DEVELOPMENT (Reina Mebius, 11th October)........................................................74
9. NEUROIMMUNOLOGY (Elga de Vries, 18th October) ....................................................................80
1
,1. INTRODUCTION (Reina Mebius, 6th September)
• Cells of the immune system
• Activation of Innate & Adaptive immune system
• Complement
• B- & T cell receptors
• MHC class I and II presentation
• T cell activation
• B cell activation
• Antibody effector functions
• Mucosal immune system
CELLS OF THE IMMUNE SYSTEM
Hematopoiesis:
Differences of the two arms of the immune response:
Innate cells can distinguish “self” and “nonself”. Macrophage receptors recognize the cell-surface
carbohydrates of bacterial cells but not those of human cells. NK cell receptors recognize changes
at the surface of human cells that are caused by viral infection.
2
, Receptors involved in phagocytosis and signaling:
The adaptive immune system starts in a secondary lymphoid organ. Lymph node is a secondary
lymphoid organ. Via the blood, cells travel through the arteries so that they can see APC that present
antigens of bacteria. When they recognize this, they can start the response of cytokines etc. If they
don’t recognize anything, the go again to the blood, so they keep circulating.
3
AND CELL BIOLOGY
By Maite Erguin
Main lecturer: Reina Mebius
Master’s in Biomedical Sciences. 2021-2022
Vrije Universiteit Amsterdam
,Contents
1. INTRODUCTION (Reina Mebius, 6th September).............................................................................2
2. DENDRITIC CELLS AND MIGRATION, HOST INNATE IMMUNE RECEPTORS (Sanne Duinkerken, 7th
September) ......................................................................................................................................19
3. T CELL PRIMING IN THE COVID-19 ERA (Joke de Haan, 13th September) ......................................32
4. (AUTO)ANTIBODIES IN HEALTH AND DISEASE (Marjolein van Egmond, 20th September,) ...........41
5. IMMUNOMETABOLISM (Jan Van den Bossche, 23rd September) .................................................50
6. IMMUNE RESPONSES TO GLYCOLIPIDS AND POLYSACCHARIDES (Sandra van Vliet, 29th
September) ......................................................................................................................................56
7. IMMUNE DEFICIENCIES (Sergey Nejentsev, 4th October) .............................................................63
8. LYMPH NODE DEVELOPMENT (Reina Mebius, 11th October)........................................................74
9. NEUROIMMUNOLOGY (Elga de Vries, 18th October) ....................................................................80
1
,1. INTRODUCTION (Reina Mebius, 6th September)
• Cells of the immune system
• Activation of Innate & Adaptive immune system
• Complement
• B- & T cell receptors
• MHC class I and II presentation
• T cell activation
• B cell activation
• Antibody effector functions
• Mucosal immune system
CELLS OF THE IMMUNE SYSTEM
Hematopoiesis:
Differences of the two arms of the immune response:
Innate cells can distinguish “self” and “nonself”. Macrophage receptors recognize the cell-surface
carbohydrates of bacterial cells but not those of human cells. NK cell receptors recognize changes
at the surface of human cells that are caused by viral infection.
2
, Receptors involved in phagocytosis and signaling:
The adaptive immune system starts in a secondary lymphoid organ. Lymph node is a secondary
lymphoid organ. Via the blood, cells travel through the arteries so that they can see APC that present
antigens of bacteria. When they recognize this, they can start the response of cytokines etc. If they
don’t recognize anything, the go again to the blood, so they keep circulating.
3
