BIOM 500 QUIZ 3 PRACTICE NEW UPDATED EXAM QUESTIONS AND ANSWERS LIBERTY UNIVERSITY

BIOM 500 QUIZ 3 PRACTICE NEW UPDATED EXAM QUESTIONS AND ANSWERS 1. Terminally differentiated cells go into the quiscent stage of the cell cycle also described as G0 Phase G1 Phase G2 Phase S phase 2. Cancer cells actively duplicate their genetic material in the stage of the cell cycle called; S Phase M Phase G1 Phase G2 Phase 3. Cyclin-dependent kinase 6 exerts its cell cycle progression effects by acting on these substrates except; Rb SMAD2 P130 p53 4. An inhibition of the kinase activity of this cyclin-dependent kinase will result in a cell cycle arrest in Gap phase 2? CDK1 CDK2 CDK3 CDK4 5. In attempting to design a drug that will impede cell cycle progression in ovarian cancers cells. you will want the drug to have this effect on the cells Increase expression of CDK7 Increase the phosphorylation of the ATP-binding pocket of CDK1 Increase expression of CDC25A All of the above 6. You are looking at the results of a western blot from the lysates of cells harvested from a suspected breast cancer tumor and you see that there is an increased expression of INK4-p16, you suspect that this will ? Increase S to G2 phase transition Initiate a cell cycle arrest in G1 Block M to G1 phase transition Promote tumorigenesis 7. The expression of this inhibitor of G2 to M Phase of the cell cycle progression will be significantly upregulated in a muscle cell that has had a drastic drop in insulin stimulation due to glucose and amino acids withdrawal; ARF CiP/KiP-p21 CiP/KiP-p27 p57 8. Which of the following statements about the G1 phase of the cell cycle is accurate? The cell is most sensitive to the extracellular environment (presence of nutrients) in the G1 phase The cell is dismantling the replicative machinery There is a restriction point in early G1 when growth factors are no longer required Rb is a promoter of G1 to S phase transition 9. During mitosis, CDK1 activity is lost due to degradation of cyclins A and B in anaphase due to the activities of this protein; Spererase Nuclear import protein 1 Cyclosome Destruction complex 10. Genetic instability and aneuploidy will most likely arise in a rapidly dividing cell due to an inhibition of the activity of ? CDK2 MDM2 Mitotic checkpoint kinase cdc25C 11. Increased rate of DNA replication is always followed by cell division in all human cells. False 12. While the absence of nutrients and growth factors often results in cell cycle arrest in normal cells, cancer cells are able to undergo cell growth independent of the presence of nutrient and growth factors giving them a selective survival advantage. True 13. The introduction of amino acids into a cancer cell culture media will cause an upregulation of mTORC1 signaling and ? Ribosome degradation Autophagy (inhibits autophagy) Protein synthesis Lipolysis and Fatty acid oxidation 14. In a cancer tissue that exhibits increased mTORC1 signaling despite nutrient deprivation, which of these modalities will most likely be effective blocking the tumor growth? Increased RAPTOR expression Decreased DEPTOR activity PRAS40 amplification All of the above 15. Which of these does not accurately describe the cellular response to insulin signaling effect on cell growth? Insulin signaling activates receptor tyrosine kinase Insulin signaling increase PTEN activity Insulin signaling increasese AKT signaling Insulin signaling downregulates Tuberous Sclerosis Complex 2 16. Which of these pathways do you suspect will increase mTORC1 signaling and promote cell growth and proliferation? Rheb activation Increased Wnt signaling Increased expression of tumor necrosis factor alpha All of these 17. In a breast tissue sample with a low ATP/AMP ratio, which of these will be an expected finding? A decrease in mTORC1 signaling Increased amounts of dephosphorylated RAPTOR Decreased expression of TSC2 Decreased AMPK activity 18. Inflicting a double stranded damage to a cell's DNA will result in increased PTEN activity and a downregulation of the mTORC1 signaling pathway. True 19. Which of these statements about cell cycle regulation is correct? Polyubiquitination of a cell cycle protein is a signal its delivery for proteosomal degradation Polyubiquitination targets proteins for export from the cell Cohesin is responsible for condensing the chromatin in prophase Seperase is the protein that holds homologous chromosomes together at the locus 20. Which of these F-box protein component of E3-ubiquitin ligase is responsible for the degradative downregulation of cyclin E and impaired cell cycle progression? Skp2 b-Trepl Fbx4 Fbw7