Walden 6630 Psychopharmacology
Midterm Study Guide
i. Serotonin regulates Correct answer-, feeding, and reproductivebehavior Mood,
emotion
ii. This class of antidepressants binds to presynaptic SERT and inhibits them from
reuptake of serotonin to increase levels in the synaptic cleft to bind with
postsysnaptic 5HT2 receptors Correct answer- SSRIs
iii. First line therapy for MDD due to milder side effect profiles Correct answer- SSRIs
iv. Six Common SSRIs Correct answer- citalopram, escitalopram, fluoxetine,
fluvoxamine, sertraline, paroxetine
v. Onset of therapeutic benefit from SSRIs Correct answer- 4-6 weeks
vi. In addition to MDD, SSRIs also treat Correct answer- Chronic Anxiety, PTSD, OCD,
and eating disorders (bulimia)
vii. Five Common side effects of SSRIs include Correct answer- Anxiety, insomnia, GI
distress, sexual dysfunction (ED), SIADH
viii. Severe side effect of SSRIs in children/adolescents under age 25 years old Correct
answer- suicidal ideation
ix. Life threatening adverse effect of SSRIs, especially when used in combination with
other serotonergic drugs (SNRIs, TCAs, MAOIs, etc.) Correct answer- Serotonin
Syndrome
x. Excess accumulation of serotonin resulting in overstimulation of the nervous
system Correct answer- Serotonin Syndrome
, xi. Seven symptoms of Serotonin Syndrome Correct answer- Flushing, hyperthermia,
agitation, muscle rigidity, seizure, coma, HYPERreflexia
xii. The treatment for serotonin syndrome Correct answer- Cyproheptadine (5-HT2
receptor antagonist)
xiii. Cyproheptadine treats serotonin syndrome by Correct answer- blocking 5-HT2
receptors (serotonin antagonist)
xiv. When SSRIs or SNRIs are stopped abruptly, common symptoms of withdrawal
include Correct answer- Irritability, headaches, and insomnia
xv. Medicine specific side effect of citalopram Correct answer- Prolonged QT interval
(normal=0.4.-0.44 seconds)
xvi. This SSRI is pregnancy category D due to associations with congenital heart
defects Correct answer- Paroxetine
xvii. All SSRIs but paroxetine (D) are pregnancy category Correct answer- C
xviii. Three SSRIs that are inhibitors of Cytochrome P450 enzymes Correct answer-
fluoxetine, fluvoxamine, and paroxetine
xix. Five common SNRIs include Correct answer- duloxetine, venlafaxine,
desvenlafaxine, milnacipran, levomilnacipran
xx. This antidepressant class of medications works by binding to presynaptic SERT
and NET to inhibit them from reuptake of serotonin and norepinephrine to
increase their levels in the synaptic cleft Correct answer- SNRIs
xxi. In addition to MDD SNRIs treat Correct answer- Anxiety and neuropathic pain
(peripheral neuropathy)
xxii. Medication specific indications of duloxetine: Correct answer- urinary
incontinence and Fibromyalgia
xxiii. Medication specific indications of venlafaxine: Correct answer- social anxiety,
panic disorders, PTSD, OCD, postmenopausal hot flashes
, xxiv. Six common side effects of SNRIs include: Correct answer- Insomnia, nausea,
sexual dysfunction, hypertension, sweating, headaches
xxv. Severe side effect of SNRIs in children/adolescents under age 25 years old:
Correct answer- suicidal ideation
xxvi. Life threatening adverse effect of SNRIs, especially when used in combination
with other serotonergic drugs: Correct answer- Serotonin Syndrome
xxvii. This SNRI is an inhibitor of Cytochrome P450 enzymes: Correct answer-
venlafaxine
xxviii. This SNRI is hepatotoxic: Correct answer- duloxetine
xxix. MAOIs increase the levels of: Correct answer- Serotonin, Norepinephrine, and
Dopamine
xxx. Norepinephrine regulates: Correct answer- alertness and focus
xxxi. Dopamine regulates: Correct answer- cognitive function, motivation, and
awakeness
xxxii. In the synaptic cleft, Monoamine Oxidase A breaks down: Correct answer-
Serotonin, Norepinephrine, and Dopamine
xxxiii. In the synaptic cleft, Monoamine Oxidase B breaks down: Correct answer-
Dopamine
xxxiv. MAOIs are especially effective in: Correct answer- Atypical depression (mood
responds to positive events and symptoms include increased appetite, weight
gain, sleepiness, and fatigue)
xxxv. Non-selective MAOIs inhibit enzymes: Correct answer- MAO-A and MAO-B
xxxvi. Selective MAOIs only inhibit the enzyme: Correct answer- MAO-B
xxxvii. Three non-selective MAOIs: Correct answer- isocarboxazid, phenelzine,
tranylcypromine
Midterm Study Guide
i. Serotonin regulates Correct answer-, feeding, and reproductivebehavior Mood,
emotion
ii. This class of antidepressants binds to presynaptic SERT and inhibits them from
reuptake of serotonin to increase levels in the synaptic cleft to bind with
postsysnaptic 5HT2 receptors Correct answer- SSRIs
iii. First line therapy for MDD due to milder side effect profiles Correct answer- SSRIs
iv. Six Common SSRIs Correct answer- citalopram, escitalopram, fluoxetine,
fluvoxamine, sertraline, paroxetine
v. Onset of therapeutic benefit from SSRIs Correct answer- 4-6 weeks
vi. In addition to MDD, SSRIs also treat Correct answer- Chronic Anxiety, PTSD, OCD,
and eating disorders (bulimia)
vii. Five Common side effects of SSRIs include Correct answer- Anxiety, insomnia, GI
distress, sexual dysfunction (ED), SIADH
viii. Severe side effect of SSRIs in children/adolescents under age 25 years old Correct
answer- suicidal ideation
ix. Life threatening adverse effect of SSRIs, especially when used in combination with
other serotonergic drugs (SNRIs, TCAs, MAOIs, etc.) Correct answer- Serotonin
Syndrome
x. Excess accumulation of serotonin resulting in overstimulation of the nervous
system Correct answer- Serotonin Syndrome
, xi. Seven symptoms of Serotonin Syndrome Correct answer- Flushing, hyperthermia,
agitation, muscle rigidity, seizure, coma, HYPERreflexia
xii. The treatment for serotonin syndrome Correct answer- Cyproheptadine (5-HT2
receptor antagonist)
xiii. Cyproheptadine treats serotonin syndrome by Correct answer- blocking 5-HT2
receptors (serotonin antagonist)
xiv. When SSRIs or SNRIs are stopped abruptly, common symptoms of withdrawal
include Correct answer- Irritability, headaches, and insomnia
xv. Medicine specific side effect of citalopram Correct answer- Prolonged QT interval
(normal=0.4.-0.44 seconds)
xvi. This SSRI is pregnancy category D due to associations with congenital heart
defects Correct answer- Paroxetine
xvii. All SSRIs but paroxetine (D) are pregnancy category Correct answer- C
xviii. Three SSRIs that are inhibitors of Cytochrome P450 enzymes Correct answer-
fluoxetine, fluvoxamine, and paroxetine
xix. Five common SNRIs include Correct answer- duloxetine, venlafaxine,
desvenlafaxine, milnacipran, levomilnacipran
xx. This antidepressant class of medications works by binding to presynaptic SERT
and NET to inhibit them from reuptake of serotonin and norepinephrine to
increase their levels in the synaptic cleft Correct answer- SNRIs
xxi. In addition to MDD SNRIs treat Correct answer- Anxiety and neuropathic pain
(peripheral neuropathy)
xxii. Medication specific indications of duloxetine: Correct answer- urinary
incontinence and Fibromyalgia
xxiii. Medication specific indications of venlafaxine: Correct answer- social anxiety,
panic disorders, PTSD, OCD, postmenopausal hot flashes
, xxiv. Six common side effects of SNRIs include: Correct answer- Insomnia, nausea,
sexual dysfunction, hypertension, sweating, headaches
xxv. Severe side effect of SNRIs in children/adolescents under age 25 years old:
Correct answer- suicidal ideation
xxvi. Life threatening adverse effect of SNRIs, especially when used in combination
with other serotonergic drugs: Correct answer- Serotonin Syndrome
xxvii. This SNRI is an inhibitor of Cytochrome P450 enzymes: Correct answer-
venlafaxine
xxviii. This SNRI is hepatotoxic: Correct answer- duloxetine
xxix. MAOIs increase the levels of: Correct answer- Serotonin, Norepinephrine, and
Dopamine
xxx. Norepinephrine regulates: Correct answer- alertness and focus
xxxi. Dopamine regulates: Correct answer- cognitive function, motivation, and
awakeness
xxxii. In the synaptic cleft, Monoamine Oxidase A breaks down: Correct answer-
Serotonin, Norepinephrine, and Dopamine
xxxiii. In the synaptic cleft, Monoamine Oxidase B breaks down: Correct answer-
Dopamine
xxxiv. MAOIs are especially effective in: Correct answer- Atypical depression (mood
responds to positive events and symptoms include increased appetite, weight
gain, sleepiness, and fatigue)
xxxv. Non-selective MAOIs inhibit enzymes: Correct answer- MAO-A and MAO-B
xxxvi. Selective MAOIs only inhibit the enzyme: Correct answer- MAO-B
xxxvii. Three non-selective MAOIs: Correct answer- isocarboxazid, phenelzine,
tranylcypromine
