NURS 660 Psychopharmacology Exam 1 Review 2023

NURS 660 Psychopharmacology Exam 1 Review 2023. Chlorpromazine (Thorazine) = low potency 1st gen SEs: Neuroleptic induced deficit syndrome, akathisia, priapism, parkinsonism, galactorrhea, amenorrhea Drug Interactions: levodopa/dopamine agonists, HTN meds, CNS depressants, pressors, ETOH/diuretics, anticoagulants, phenytoin, propranolol, lithium Serious Adverse Events: NMS, jaundice, agranulocytosis, seizures FDA Indications: schizophrenia, severe behavioral problems…, acute psychosis, n/v, acute intermittent porphyria, tetanus, intractable hiccups Lab work/Monitoring: weight, BMI, triglycerides o Clozapine (Clozaril) = 2nd gen SEs: Weight gain, sedation, drooling, orthostatic hypotension, tachycardia, dyslipidemia Drug Interactions: caffeine and smoking, cyp1a2 inhibitors (fluvoxamine, ciprofloxacin), cyp2d6 inhibitors (bupropion, duloxetine, paroxetine, fluoxetine), 3a4 inhibitors (ketoconazole), antihypertensives, levodopa/dopamine agonists Serious Adverse Events: Myocarditis/cardiomyopathy, agranulocytosis, seizures, paralytic ileus, hyperglycemia, PE, NMS FDA Indications: Treatment resistant schizophrenia, schizophrenia or schizoaffective disorder (recurrent suicidal behavior) Lab work/Monitoring: Bowel function, ANC 1500, myocarditis, troponin, Weight, BMI, lipids, BP, BG, CBC o Haloperidol (Haldol) = high potency 1st gen, depot formulation SEs: weight gain, neuroleptic induced deficit syndrome, akathisia, parkinsonism, TD, galactorrhea, amenorrhea, anticholinergic Drug Interactions: dopamine agonists/levodopa, HTN drugs, CNS depressants, pressors, anticholinergics (intraocular pressure), anticoagulants, rifampin, lithium Serious Adverse Events: NMS, seizures, jaundice, agranulocytosis, leukopenia FDA Indications: psychotic disorders, tics/vocal tourettes, 2nd line in severe behavioral problems/hyperactive children, schizophrenia Lab work/Monitoring: weight, BMI, triglycerides, prolactin, CBC, BG o Lurasidone (Latuda) = 2nd gen, must take with 350 calories of food, safe with pregnancy, low weight gain