NR566 Final (Advanced Pharmacology for Care of the Family) questions with certified answers

Anti-Androgens Ans Finasteride (Propecia) Leuprolide (Eligard, Lupron, Lupron Depot) Spironolactone (Aldactone) Finasteride (Propecia, Proscar) Ans blocks conversion of testosterone to dihydrotesterone Used to tx: -BPH -male pattern baldness 3 months of therapy need to see benefits Stopping, reverses effect w/in 12 months Adverse side effects: - Decreased libido -Impotence dutasteride (Avodart) Ans 5-alpha reductase inhibitor used to tx: BPH Can stay in serum up to 6 mon after discontinuing can be absorbed through skin pregnant woman shouldn't handle capsules (fetal anomaly in male fetus) Adverse Effects decreased libido Impotence Leuprolide Acetate (Lupron) Ans Luteinizing hormone - releasing agonist create reversible: -orchiectomy state -oophorectomy state Used to tx: - advanced prostatic cancer - Management of endometriosis - Uterine fibroids - polycystic ovarian disease - central precocious puberty in peds Flutamide (Eulexin, Euflex) Ans Truly non-steroidal agent Used to tx: -Advanced prostate cancer -female androgen excess syndrome Adverse Effects in males - gynecomastia -reversible liver toxicity Black Box Warning -hepatic failure -hepatic encephalopathy Basline/monthly liver function test for 1st 4 months Spironolactone (Aldactone) Ans aldosterone antagonist potassium sparing diuretic used for tx: -female hirsutism (abnormal growth of hair) -acne -relief of PMS/PMDD symptoms (25-50 mg/d) Adverse reactions - dose related + reversible when discont. -GI upset -Drowsiness -Gynecomastia -Impotence -Cutaneous (skin) eruptions - Urticaria Black Box Warning Tumorigenicity in animals Should not be used during pregnancy Androgen Ans Testosterone most important adrogen in humans levels remain stable at 55yr 70 yrs men decrease in -strength, libido, muscle mass