LE 5 – Osmoregulation
November 22 n d , 2023
Osmoregulation
Regulati on of water
Molecule Water
Concept Water uptake independent of sodium
Hormone Vasopressin (AVP/ADH)
Disease Hypo/hypernatremia
Uncoupling
of Na and H2O transport
+
Osmoreceptors
Effective osmoles
1% variation
Baroreceptors
Blood pressure
5-10% variation
, H2O transport along the nephron
Regulation of H2O transport – Vasopressin
Hypothalamus contains osmo-sensors
Pituitary secretes arginine vasopressin (AVP), also known
as anti-diuretic hormone (ADH)
AVP activates V2 receptors in the collecting duct
November 22 n d , 2023
Osmoregulation
Regulati on of water
Molecule Water
Concept Water uptake independent of sodium
Hormone Vasopressin (AVP/ADH)
Disease Hypo/hypernatremia
Uncoupling
of Na and H2O transport
+
Osmoreceptors
Effective osmoles
1% variation
Baroreceptors
Blood pressure
5-10% variation
, H2O transport along the nephron
Regulation of H2O transport – Vasopressin
Hypothalamus contains osmo-sensors
Pituitary secretes arginine vasopressin (AVP), also known
as anti-diuretic hormone (ADH)
AVP activates V2 receptors in the collecting duct