UNE Medical Biochemistry Exam 1 Questions With
Complete Solutions.
what percentage of water is in the body?
60%
Relationship between protons and acids & bases
Acids donate proton. Bases accept proton
Strong Acids Vs Weak Acids
Strong acids fully dissociate (100%) and weak acids partially dissociate
properties of water
dipole dipole
polar
H bonding
dissolves electrolytes ( CL /Na)
Small Kd- doesn't dissociate alot
kw ion product
10^-14
pH
-log[H+]
biological PH
7.4
types of buffers
phosphates, bicarbonate, proteins
Buffers
weak acid and conjugate base
Ka
how well acid can dissociate
pka
-log(Ka)
50%dissociation
Buffers work best when?
ph=pka
within +/- 1 ph unit of pka
Henderson-Hasselbalch equation
pH= pka + log A-/HA
pH<pKa
protonated
pH>pKa
ionized
amino acids are linked together by
peptide bonds between carboxyl and amino group
what's special about histidine pka?
close to biological PH of 7.4 so it can act as an donor or acceptor
nonpolar amino acids
, glycine
alanine
proline
valine
leucine
isoleucine
Aromatic Amino Acids
phenylalanine, tyrosine, tryptophan
polar uncharged amino acids
asparagine
glutamine
serine
threonine
sulfur containing amino acids
methionine
cysteine
charged amino acids
aspartate
glutamate
arginine
lysine
histidine
which 3 amino acids carry ammonia?
glutamine, glutamate, alanine
which 3 amino acids can be phosphorylated?
serine, threonine, tyrosine
pka of COOH and NH2
2 and 9
what interactions can proteins have?
electrostatic forces
dipole dipole
h bonding
hydrophobic interactions
Alpha helix bonding
h bond between carbonyl O and amide 4 residues down
R groups stick out of helix
hydrophobic core
beta sheet bonding
h bonding between carbonyl O and amide across from each other
R groups stick out
Amyloid plaques
aggregates of Amino acids
Motif Vs Fold
secondary (common arrangement)
VS TERTIARY
types of folds
Complete Solutions.
what percentage of water is in the body?
60%
Relationship between protons and acids & bases
Acids donate proton. Bases accept proton
Strong Acids Vs Weak Acids
Strong acids fully dissociate (100%) and weak acids partially dissociate
properties of water
dipole dipole
polar
H bonding
dissolves electrolytes ( CL /Na)
Small Kd- doesn't dissociate alot
kw ion product
10^-14
pH
-log[H+]
biological PH
7.4
types of buffers
phosphates, bicarbonate, proteins
Buffers
weak acid and conjugate base
Ka
how well acid can dissociate
pka
-log(Ka)
50%dissociation
Buffers work best when?
ph=pka
within +/- 1 ph unit of pka
Henderson-Hasselbalch equation
pH= pka + log A-/HA
pH<pKa
protonated
pH>pKa
ionized
amino acids are linked together by
peptide bonds between carboxyl and amino group
what's special about histidine pka?
close to biological PH of 7.4 so it can act as an donor or acceptor
nonpolar amino acids
, glycine
alanine
proline
valine
leucine
isoleucine
Aromatic Amino Acids
phenylalanine, tyrosine, tryptophan
polar uncharged amino acids
asparagine
glutamine
serine
threonine
sulfur containing amino acids
methionine
cysteine
charged amino acids
aspartate
glutamate
arginine
lysine
histidine
which 3 amino acids carry ammonia?
glutamine, glutamate, alanine
which 3 amino acids can be phosphorylated?
serine, threonine, tyrosine
pka of COOH and NH2
2 and 9
what interactions can proteins have?
electrostatic forces
dipole dipole
h bonding
hydrophobic interactions
Alpha helix bonding
h bond between carbonyl O and amide 4 residues down
R groups stick out of helix
hydrophobic core
beta sheet bonding
h bonding between carbonyl O and amide across from each other
R groups stick out
Amyloid plaques
aggregates of Amino acids
Motif Vs Fold
secondary (common arrangement)
VS TERTIARY
types of folds
